An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5′Hoxd–Gli3 antagonism

The molecular mechanisms governing digit joint specification are poorly understood. Here, the authors identify the 5′Hoxd–Gli3 balance as a key regulator of the net interdigital Bmp signalling level in mouse, which in turn regulates phalanx and joint formation.

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Autores principales:	Bau-Lin Huang, Anna Trofka, Aki Furusawa, Jacqueline L. Norrie, Adam H. Rabinowitz, Steven A. Vokes, M. Mark Taketo, Jozsef Zakany, Susan Mackem
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b589df54b71a442db003ba86c874cc67
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spelling	oai:doaj.org-article:b589df54b71a442db003ba86c874cc672021-12-02T16:56:45ZAn interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5′Hoxd–Gli3 antagonism10.1038/ncomms129032041-1723https://doaj.org/article/b589df54b71a442db003ba86c874cc672016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12903https://doaj.org/toc/2041-1723The molecular mechanisms governing digit joint specification are poorly understood. Here, the authors identify the 5′Hoxd–Gli3 balance as a key regulator of the net interdigital Bmp signalling level in mouse, which in turn regulates phalanx and joint formation.Bau-Lin HuangAnna TrofkaAki FurusawaJacqueline L. NorrieAdam H. RabinowitzSteven A. VokesM. Mark TaketoJozsef ZakanySusan MackemNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bau-Lin Huang Anna Trofka Aki Furusawa Jacqueline L. Norrie Adam H. Rabinowitz Steven A. Vokes M. Mark Taketo Jozsef Zakany Susan Mackem An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5′Hoxd–Gli3 antagonism
description	The molecular mechanisms governing digit joint specification are poorly understood. Here, the authors identify the 5′Hoxd–Gli3 balance as a key regulator of the net interdigital Bmp signalling level in mouse, which in turn regulates phalanx and joint formation.
format	article
author	Bau-Lin Huang Anna Trofka Aki Furusawa Jacqueline L. Norrie Adam H. Rabinowitz Steven A. Vokes M. Mark Taketo Jozsef Zakany Susan Mackem
author_facet	Bau-Lin Huang Anna Trofka Aki Furusawa Jacqueline L. Norrie Adam H. Rabinowitz Steven A. Vokes M. Mark Taketo Jozsef Zakany Susan Mackem
author_sort	Bau-Lin Huang
title	An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5′Hoxd–Gli3 antagonism
title_short	An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5′Hoxd–Gli3 antagonism
title_full	An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5′Hoxd–Gli3 antagonism
title_fullStr	An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5′Hoxd–Gli3 antagonism
title_full_unstemmed	An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5′Hoxd–Gli3 antagonism
title_sort	interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5′hoxd–gli3 antagonism
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b589df54b71a442db003ba86c874cc67
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An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5′Hoxd–Gli3 antagonism

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