Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB

The Yersinia YaxAB system is a pore-forming toxin of so far unknown structure. Here authors present X-ray and cryo-EM to structures of individual subunits and of the YaxAB pore complex, and find that YaxA binds to membranes first and recruits YaxB for subsequent oligomerization.

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Autores principales:	Bastian Bräuning, Eva Bertosin, Florian Praetorius, Christian Ihling, Alexandra Schatt, Agnes Adler, Klaus Richter, Andrea Sinz, Hendrik Dietz, Michael Groll
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b58d61f8141a4986b198653b2a2a0a9c
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spelling	oai:doaj.org-article:b58d61f8141a4986b198653b2a2a0a9c2021-12-02T14:40:09ZStructure and mechanism of the two-component α-helical pore-forming toxin YaxAB10.1038/s41467-018-04139-22041-1723https://doaj.org/article/b58d61f8141a4986b198653b2a2a0a9c2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04139-2https://doaj.org/toc/2041-1723The Yersinia YaxAB system is a pore-forming toxin of so far unknown structure. Here authors present X-ray and cryo-EM to structures of individual subunits and of the YaxAB pore complex, and find that YaxA binds to membranes first and recruits YaxB for subsequent oligomerization.Bastian BräuningEva BertosinFlorian PraetoriusChristian IhlingAlexandra SchattAgnes AdlerKlaus RichterAndrea SinzHendrik DietzMichael GrollNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bastian Bräuning Eva Bertosin Florian Praetorius Christian Ihling Alexandra Schatt Agnes Adler Klaus Richter Andrea Sinz Hendrik Dietz Michael Groll Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB
description	The Yersinia YaxAB system is a pore-forming toxin of so far unknown structure. Here authors present X-ray and cryo-EM to structures of individual subunits and of the YaxAB pore complex, and find that YaxA binds to membranes first and recruits YaxB for subsequent oligomerization.
format	article
author	Bastian Bräuning Eva Bertosin Florian Praetorius Christian Ihling Alexandra Schatt Agnes Adler Klaus Richter Andrea Sinz Hendrik Dietz Michael Groll
author_facet	Bastian Bräuning Eva Bertosin Florian Praetorius Christian Ihling Alexandra Schatt Agnes Adler Klaus Richter Andrea Sinz Hendrik Dietz Michael Groll
author_sort	Bastian Bräuning
title	Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB
title_short	Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB
title_full	Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB
title_fullStr	Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB
title_full_unstemmed	Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB
title_sort	structure and mechanism of the two-component α-helical pore-forming toxin yaxab
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b58d61f8141a4986b198653b2a2a0a9c
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Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB

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