Nasal displacement of retinal vessels on the optic disc in glaucoma associated with a nasally angled passage through lamina cribrosa

Abstract To investigate nasal displacement of central retinal vessel (CRV) on the optic nerve head (ONH) in glaucoma in association with its passage through lamina cribrosa (LC). This cross-sectional study included 113 eyes with glaucoma and 60 normal eyes. Horizontal spectral-domain optical coheren...

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Autores principales:	Yu Sawada, Makoto Araie, Hitomi Shibata, Takeshi Iwase
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b58efb5762504f23a2d8415048842e53
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spelling	oai:doaj.org-article:b58efb5762504f23a2d8415048842e532021-12-02T12:11:07ZNasal displacement of retinal vessels on the optic disc in glaucoma associated with a nasally angled passage through lamina cribrosa10.1038/s41598-021-83720-02045-2322https://doaj.org/article/b58efb5762504f23a2d8415048842e532021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83720-0https://doaj.org/toc/2045-2322Abstract To investigate nasal displacement of central retinal vessel (CRV) on the optic nerve head (ONH) in glaucoma in association with its passage through lamina cribrosa (LC). This cross-sectional study included 113 eyes with glaucoma and 60 normal eyes. Horizontal spectral-domain optical coherence tomography (SD-OCT) scans of the ONH were acquired, and point where CRV emerged on the ONH surface was defined as the position of the CRV. Next, radial scans of the ONH were acquired, and angle of the CRV passing through the LC was measured. These parameters were compared between glaucomatous and normal eyes by t-test, and their relationship with possible confounders was assessed by multiple regression analyses. In glaucoma, CRV was significantly more nasally displaced than it was in normal eyes (66.0 ± 8.6 vs. 54.3 ± 9.5, P < 0.0001), and eyes with more vessel displacement exhibited significantly worse glaucomatous visual field defects (P = 0.0004). Greater nasal displacement of the CRV was significantly associated with a more nasally angled path through the LC (rs = 0.569, P < 0.0001). By using SD-OCT, we confirmed that nasal displacement of the CRV on the ONH was associated with glaucoma and was induced by its nasally angled path through the LC.Yu SawadaMakoto AraieHitomi ShibataTakeshi IwaseNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu Sawada Makoto Araie Hitomi Shibata Takeshi Iwase Nasal displacement of retinal vessels on the optic disc in glaucoma associated with a nasally angled passage through lamina cribrosa
description	Abstract To investigate nasal displacement of central retinal vessel (CRV) on the optic nerve head (ONH) in glaucoma in association with its passage through lamina cribrosa (LC). This cross-sectional study included 113 eyes with glaucoma and 60 normal eyes. Horizontal spectral-domain optical coherence tomography (SD-OCT) scans of the ONH were acquired, and point where CRV emerged on the ONH surface was defined as the position of the CRV. Next, radial scans of the ONH were acquired, and angle of the CRV passing through the LC was measured. These parameters were compared between glaucomatous and normal eyes by t-test, and their relationship with possible confounders was assessed by multiple regression analyses. In glaucoma, CRV was significantly more nasally displaced than it was in normal eyes (66.0 ± 8.6 vs. 54.3 ± 9.5, P < 0.0001), and eyes with more vessel displacement exhibited significantly worse glaucomatous visual field defects (P = 0.0004). Greater nasal displacement of the CRV was significantly associated with a more nasally angled path through the LC (rs = 0.569, P < 0.0001). By using SD-OCT, we confirmed that nasal displacement of the CRV on the ONH was associated with glaucoma and was induced by its nasally angled path through the LC.
format	article
author	Yu Sawada Makoto Araie Hitomi Shibata Takeshi Iwase
author_facet	Yu Sawada Makoto Araie Hitomi Shibata Takeshi Iwase
author_sort	Yu Sawada
title	Nasal displacement of retinal vessels on the optic disc in glaucoma associated with a nasally angled passage through lamina cribrosa
title_short	Nasal displacement of retinal vessels on the optic disc in glaucoma associated with a nasally angled passage through lamina cribrosa
title_full	Nasal displacement of retinal vessels on the optic disc in glaucoma associated with a nasally angled passage through lamina cribrosa
title_fullStr	Nasal displacement of retinal vessels on the optic disc in glaucoma associated with a nasally angled passage through lamina cribrosa
title_full_unstemmed	Nasal displacement of retinal vessels on the optic disc in glaucoma associated with a nasally angled passage through lamina cribrosa
title_sort	nasal displacement of retinal vessels on the optic disc in glaucoma associated with a nasally angled passage through lamina cribrosa
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b58efb5762504f23a2d8415048842e53
work_keys_str_mv	AT yusawada nasaldisplacementofretinalvesselsontheopticdiscinglaucomaassociatedwithanasallyangledpassagethroughlaminacribrosa AT makotoaraie nasaldisplacementofretinalvesselsontheopticdiscinglaucomaassociatedwithanasallyangledpassagethroughlaminacribrosa AT hitomishibata nasaldisplacementofretinalvesselsontheopticdiscinglaucomaassociatedwithanasallyangledpassagethroughlaminacribrosa AT takeshiiwase nasaldisplacementofretinalvesselsontheopticdiscinglaucomaassociatedwithanasallyangledpassagethroughlaminacribrosa
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Nasal displacement of retinal vessels on the optic disc in glaucoma associated with a nasally angled passage through lamina cribrosa

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