Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines

Coronavirus disease 2019 (COVID-19) pandemic is a serious threat to global public health and social and economic development. Various vaccine platforms have been developed rapidly and unprecedentedly, and at least 16 vaccines receive emergency use authorization (EUA). However, the causative pathogen...

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Autores principales:	Yandi Zhang, Jo-Lewis Banga Ndzouboukou, Mengze Gan, Xiaosong Lin, Xionglin Fan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	COVID-19 SARS-CoV-2 variants vaccine efficacy immune evasive epidemiology Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b58f191aff914f5eb4c8f384750a530c
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spelling	oai:doaj.org-article:b58f191aff914f5eb4c8f384750a530c2021-11-22T06:00:53ZImmune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines1664-322410.3389/fimmu.2021.771242https://doaj.org/article/b58f191aff914f5eb4c8f384750a530c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.771242/fullhttps://doaj.org/toc/1664-3224Coronavirus disease 2019 (COVID-19) pandemic is a serious threat to global public health and social and economic development. Various vaccine platforms have been developed rapidly and unprecedentedly, and at least 16 vaccines receive emergency use authorization (EUA). However, the causative pathogen severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has continued to evolve and mutate, emerging lots of viral variants. Several variants have successfully become the predominant strains and spread all over the world because of their ability to evade the pre-existing immunity obtained after previous infections with prototype strain or immunizations. Here, we summarized the prevalence and biological structure of these variants and the efficacy of currently used vaccines against the SARS-CoV-2 variants to provide guidance on how to design vaccines more rationally against the variants.Yandi ZhangJo-Lewis Banga NdzouboukouMengze GanXiaosong LinXionglin FanFrontiers Media S.A.articleCOVID-19SARS-CoV-2 variantsvaccine efficacyimmune evasiveepidemiologyImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 variants vaccine efficacy immune evasive epidemiology Immunologic diseases. Allergy RC581-607
spellingShingle	COVID-19 SARS-CoV-2 variants vaccine efficacy immune evasive epidemiology Immunologic diseases. Allergy RC581-607 Yandi Zhang Jo-Lewis Banga Ndzouboukou Mengze Gan Xiaosong Lin Xionglin Fan Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines
description	Coronavirus disease 2019 (COVID-19) pandemic is a serious threat to global public health and social and economic development. Various vaccine platforms have been developed rapidly and unprecedentedly, and at least 16 vaccines receive emergency use authorization (EUA). However, the causative pathogen severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has continued to evolve and mutate, emerging lots of viral variants. Several variants have successfully become the predominant strains and spread all over the world because of their ability to evade the pre-existing immunity obtained after previous infections with prototype strain or immunizations. Here, we summarized the prevalence and biological structure of these variants and the efficacy of currently used vaccines against the SARS-CoV-2 variants to provide guidance on how to design vaccines more rationally against the variants.
format	article
author	Yandi Zhang Jo-Lewis Banga Ndzouboukou Mengze Gan Xiaosong Lin Xionglin Fan
author_facet	Yandi Zhang Jo-Lewis Banga Ndzouboukou Mengze Gan Xiaosong Lin Xionglin Fan
author_sort	Yandi Zhang
title	Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines
title_short	Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines
title_full	Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines
title_fullStr	Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines
title_full_unstemmed	Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines
title_sort	immune evasive effects of sars-cov-2 variants to covid-19 emergency used vaccines
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b58f191aff914f5eb4c8f384750a530c
work_keys_str_mv	AT yandizhang immuneevasiveeffectsofsarscov2variantstocovid19emergencyusedvaccines AT jolewisbangandzouboukou immuneevasiveeffectsofsarscov2variantstocovid19emergencyusedvaccines AT mengzegan immuneevasiveeffectsofsarscov2variantstocovid19emergencyusedvaccines AT xiaosonglin immuneevasiveeffectsofsarscov2variantstocovid19emergencyusedvaccines AT xionglinfan immuneevasiveeffectsofsarscov2variantstocovid19emergencyusedvaccines
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Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines

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