On the antiquity of cancer: evidence for metastatic carcinoma in a young man from ancient Nubia (c. 1200 BC).

Cancer, one of the world's leading causes of death today, remains almost absent relative to other pathological conditions, in the archaeological record, giving rise to the conclusion that the disease is mainly a product of modern living and increased longevity. This paper presents a male, young...

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Autores principales:	Michaela Binder, Charlotte Roberts, Neal Spencer, Daniel Antoine, Caroline Cartwright
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b5963082f9f9411c9a4b52664ee8449b
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spelling	oai:doaj.org-article:b5963082f9f9411c9a4b52664ee8449b2021-11-18T08:27:43ZOn the antiquity of cancer: evidence for metastatic carcinoma in a young man from ancient Nubia (c. 1200 BC).1932-620310.1371/journal.pone.0090924https://doaj.org/article/b5963082f9f9411c9a4b52664ee8449b2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24637948/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Cancer, one of the world's leading causes of death today, remains almost absent relative to other pathological conditions, in the archaeological record, giving rise to the conclusion that the disease is mainly a product of modern living and increased longevity. This paper presents a male, young-adult individual from the archaeological site of Amara West in northern Sudan (c. 1200 BC) displaying multiple, mainly osteolytic, lesions on the vertebrae, ribs, sternum, clavicles, scapulae, pelvis, and humeral and femoral heads. Following radiographic, microscopic and scanning electron microscopic (SEM) imaging of the lesions, and a consideration of differential diagnoses, a diagnosis of metastatic carcinoma secondary to an unknown soft tissue cancer is suggested. This represents the earliest complete example in the world of a human who suffered metastatic cancer to date. The study further draws its strength from modern analytical techniques applied to differential diagnoses and the fact that it is firmly rooted within a well-documented archaeological and historical context, thus providing new insights into the history and antiquity of the disease as well as its underlying causes and progression.Michaela BinderCharlotte RobertsNeal SpencerDaniel AntoineCaroline CartwrightPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e90924 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michaela Binder Charlotte Roberts Neal Spencer Daniel Antoine Caroline Cartwright On the antiquity of cancer: evidence for metastatic carcinoma in a young man from ancient Nubia (c. 1200 BC).
description	Cancer, one of the world's leading causes of death today, remains almost absent relative to other pathological conditions, in the archaeological record, giving rise to the conclusion that the disease is mainly a product of modern living and increased longevity. This paper presents a male, young-adult individual from the archaeological site of Amara West in northern Sudan (c. 1200 BC) displaying multiple, mainly osteolytic, lesions on the vertebrae, ribs, sternum, clavicles, scapulae, pelvis, and humeral and femoral heads. Following radiographic, microscopic and scanning electron microscopic (SEM) imaging of the lesions, and a consideration of differential diagnoses, a diagnosis of metastatic carcinoma secondary to an unknown soft tissue cancer is suggested. This represents the earliest complete example in the world of a human who suffered metastatic cancer to date. The study further draws its strength from modern analytical techniques applied to differential diagnoses and the fact that it is firmly rooted within a well-documented archaeological and historical context, thus providing new insights into the history and antiquity of the disease as well as its underlying causes and progression.
format	article
author	Michaela Binder Charlotte Roberts Neal Spencer Daniel Antoine Caroline Cartwright
author_facet	Michaela Binder Charlotte Roberts Neal Spencer Daniel Antoine Caroline Cartwright
author_sort	Michaela Binder
title	On the antiquity of cancer: evidence for metastatic carcinoma in a young man from ancient Nubia (c. 1200 BC).
title_short	On the antiquity of cancer: evidence for metastatic carcinoma in a young man from ancient Nubia (c. 1200 BC).
title_full	On the antiquity of cancer: evidence for metastatic carcinoma in a young man from ancient Nubia (c. 1200 BC).
title_fullStr	On the antiquity of cancer: evidence for metastatic carcinoma in a young man from ancient Nubia (c. 1200 BC).
title_full_unstemmed	On the antiquity of cancer: evidence for metastatic carcinoma in a young man from ancient Nubia (c. 1200 BC).
title_sort	on the antiquity of cancer: evidence for metastatic carcinoma in a young man from ancient nubia (c. 1200 bc).
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/b5963082f9f9411c9a4b52664ee8449b
work_keys_str_mv	AT michaelabinder ontheantiquityofcancerevidenceformetastaticcarcinomainayoungmanfromancientnubiac1200bc AT charlotteroberts ontheantiquityofcancerevidenceformetastaticcarcinomainayoungmanfromancientnubiac1200bc AT nealspencer ontheantiquityofcancerevidenceformetastaticcarcinomainayoungmanfromancientnubiac1200bc AT danielantoine ontheantiquityofcancerevidenceformetastaticcarcinomainayoungmanfromancientnubiac1200bc AT carolinecartwright ontheantiquityofcancerevidenceformetastaticcarcinomainayoungmanfromancientnubiac1200bc
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On the antiquity of cancer: evidence for metastatic carcinoma in a young man from ancient Nubia (c. 1200 BC).

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