$Impact of corneal parameters, refractive error and age on density and morphology of the subbasal nerve plexus fibers in healthy adults$
Código QR

Impact of corneal parameters, refractive error and age on density and morphology of the subbasal nerve plexus fibers in healthy adults

Abstract The purpose of this study was to analyze corneal sub-basal nerve plexus (SBNP) density and morphology and their relationships with corneal parameters and refractive status. In this single center study, in vivo confocal microscopy (IVCM) was performed in 76 eyes of 38 healthy subjects aged 1...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anna M. Roszkowska, Adam Wylęgała, Romana Gargano, Rosaria Spinella, Leandro Inferrera, Bogusława Orzechowska-Wylęgała, Pasquale Aragona
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b599865a0db24538a4690e6c806d2068
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b599865a0db24538a4690e6c806d2068
record_format	dspace
spelling	oai:doaj.org-article:b599865a0db24538a4690e6c806d20682021-12-02T13:18:02ZImpact of corneal parameters, refractive error and age on density and morphology of the subbasal nerve plexus fibers in healthy adults10.1038/s41598-021-85597-52045-2322https://doaj.org/article/b599865a0db24538a4690e6c806d20682021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85597-5https://doaj.org/toc/2045-2322Abstract The purpose of this study was to analyze corneal sub-basal nerve plexus (SBNP) density and morphology and their relationships with corneal parameters and refractive status. In this single center study, in vivo confocal microscopy (IVCM) was performed in 76 eyes of 38 healthy subjects aged 19–87 (mean age 34.987 ± 1.148). Nerve fiber analysis was performed using Confoscan 4 microscope with semi-automated software (Nidek Technologies, Italy) The nerve fiber length (NFL) µm/mm2, nerve fiber density (NFD) no./mm2, tortuosity coefficient (TC), and nerve beadings density (NBD) no./mm were considered. Relationship between SBNP parameters and corneal curvature, thickness, diameter, and refraction were analyzed. Additionally, the association with gender, laterality and age were determined. NFL was inversely correlated with age (r = − 0.528, p < 0.001), myopic refractive error (spherical value) (r = − 0.423, p < 0.001), and cylindrical power (r = − 0.340, p = 0.003). NFD was inversely correlated with age (r = − 0.420, p < 0.001) and myopic refractive error (r = − 0.341, p = 0.003). NBD showed a low inverse correlation with cylindrical power (r = − 0.287, p = 0.012) and a slight positive correlation with K (r = 0.230, p = 0.047). TC showed a significant negative correlation between age (r = − 0.500, p < 0.001) and myopic refractive error (r = − 0.351, p = 0.002). Additionally, there were strong positive correlations between NFL and NFD (r = 0.523, p < 0.001), NFL and TI (r = 0.603, p < 0.001), and NFD and TC (r = 0.758, p < 0.001). Multiple regression analysis revealed age to be the most significant factor affecting SBNP density (B = − 0.467, p = 0.013) and length (B = − 61.446, p < 0.001); myopic refractive error reduced both SBNP density (B = − 2.119, p = 0.011) and length (B = − 158.433, p = 0.016), while gender and laterality had no significant effects (p > 0.005). SBNP fiber length decreases with age, myopic refractive error and cylindrical power. SBNP fiber density reduces with age and myopic refractive error. Corneal nerve parameters are not influenced by gender or laterality.Anna M. RoszkowskaAdam WylęgałaRomana GarganoRosaria SpinellaLeandro InferreraBogusława Orzechowska-WylęgałaPasquale AragonaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna M. Roszkowska Adam Wylęgała Romana Gargano Rosaria Spinella Leandro Inferrera Bogusława Orzechowska-Wylęgała Pasquale Aragona Impact of corneal parameters, refractive error and age on density and morphology of the subbasal nerve plexus fibers in healthy adults
description	Abstract The purpose of this study was to analyze corneal sub-basal nerve plexus (SBNP) density and morphology and their relationships with corneal parameters and refractive status. In this single center study, in vivo confocal microscopy (IVCM) was performed in 76 eyes of 38 healthy subjects aged 19–87 (mean age 34.987 ± 1.148). Nerve fiber analysis was performed using Confoscan 4 microscope with semi-automated software (Nidek Technologies, Italy) The nerve fiber length (NFL) µm/mm2, nerve fiber density (NFD) no./mm2, tortuosity coefficient (TC), and nerve beadings density (NBD) no./mm were considered. Relationship between SBNP parameters and corneal curvature, thickness, diameter, and refraction were analyzed. Additionally, the association with gender, laterality and age were determined. NFL was inversely correlated with age (r = − 0.528, p < 0.001), myopic refractive error (spherical value) (r = − 0.423, p < 0.001), and cylindrical power (r = − 0.340, p = 0.003). NFD was inversely correlated with age (r = − 0.420, p < 0.001) and myopic refractive error (r = − 0.341, p = 0.003). NBD showed a low inverse correlation with cylindrical power (r = − 0.287, p = 0.012) and a slight positive correlation with K (r = 0.230, p = 0.047). TC showed a significant negative correlation between age (r = − 0.500, p < 0.001) and myopic refractive error (r = − 0.351, p = 0.002). Additionally, there were strong positive correlations between NFL and NFD (r = 0.523, p < 0.001), NFL and TI (r = 0.603, p < 0.001), and NFD and TC (r = 0.758, p < 0.001). Multiple regression analysis revealed age to be the most significant factor affecting SBNP density (B = − 0.467, p = 0.013) and length (B = − 61.446, p < 0.001); myopic refractive error reduced both SBNP density (B = − 2.119, p = 0.011) and length (B = − 158.433, p = 0.016), while gender and laterality had no significant effects (p > 0.005). SBNP fiber length decreases with age, myopic refractive error and cylindrical power. SBNP fiber density reduces with age and myopic refractive error. Corneal nerve parameters are not influenced by gender or laterality.
format	article
author	Anna M. Roszkowska Adam Wylęgała Romana Gargano Rosaria Spinella Leandro Inferrera Bogusława Orzechowska-Wylęgała Pasquale Aragona
author_facet	Anna M. Roszkowska Adam Wylęgała Romana Gargano Rosaria Spinella Leandro Inferrera Bogusława Orzechowska-Wylęgała Pasquale Aragona
author_sort	Anna M. Roszkowska
title	Impact of corneal parameters, refractive error and age on density and morphology of the subbasal nerve plexus fibers in healthy adults
title_short	Impact of corneal parameters, refractive error and age on density and morphology of the subbasal nerve plexus fibers in healthy adults
title_full	Impact of corneal parameters, refractive error and age on density and morphology of the subbasal nerve plexus fibers in healthy adults
title_fullStr	Impact of corneal parameters, refractive error and age on density and morphology of the subbasal nerve plexus fibers in healthy adults
title_full_unstemmed	Impact of corneal parameters, refractive error and age on density and morphology of the subbasal nerve plexus fibers in healthy adults
title_sort	impact of corneal parameters, refractive error and age on density and morphology of the subbasal nerve plexus fibers in healthy adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b599865a0db24538a4690e6c806d2068
work_keys_str_mv	AT annamroszkowska impactofcornealparametersrefractiveerrorandageondensityandmorphologyofthesubbasalnerveplexusfibersinhealthyadults AT adamwylegała impactofcornealparametersrefractiveerrorandageondensityandmorphologyofthesubbasalnerveplexusfibersinhealthyadults AT romanagargano impactofcornealparametersrefractiveerrorandageondensityandmorphologyofthesubbasalnerveplexusfibersinhealthyadults AT rosariaspinella impactofcornealparametersrefractiveerrorandageondensityandmorphologyofthesubbasalnerveplexusfibersinhealthyadults AT leandroinferrera impactofcornealparametersrefractiveerrorandageondensityandmorphologyofthesubbasalnerveplexusfibersinhealthyadults AT bogusławaorzechowskawylegała impactofcornealparametersrefractiveerrorandageondensityandmorphologyofthesubbasalnerveplexusfibersinhealthyadults AT pasqualearagona impactofcornealparametersrefractiveerrorandageondensityandmorphologyofthesubbasalnerveplexusfibersinhealthyadults
_version_	1718393292514656256

Impact of corneal parameters, refractive error and age on density and morphology of the subbasal nerve plexus fibers in healthy adults

Ejemplares similares