Autoimmune Mechanisms of Cardiac Remodeling in Chronic Obstructive Pulmonary Disease

Patients with chronic obstructive pulmonary disease (COPD) have high risk of cardiovascular events due to the remodeling of the heart and vessels. We investigated whether in COPD cardiac remodeling is associated with immune response to the inflammation by studying activated T-lymphocytes, CD3+, CD4+...

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Autores principales:	Dielievska V., Kravchun P.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2017
Materias:	leukocyte migration inhibitory factor remodeling of the left ventricle bacterial sensibilization autoimmune lymphocytotoxic antibodies Medicine R
Acceso en línea:	https://doaj.org/article/b59c5bf955864839a9b024322baaac82
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spelling	oai:doaj.org-article:b59c5bf955864839a9b024322baaac822021-12-02T19:11:12ZAutoimmune Mechanisms of Cardiac Remodeling in Chronic Obstructive Pulmonary Disease0324-175010.1515/amb-2017-0002https://doaj.org/article/b59c5bf955864839a9b024322baaac822017-05-01T00:00:00Zhttps://doi.org/10.1515/amb-2017-0002https://doaj.org/toc/0324-1750Patients with chronic obstructive pulmonary disease (COPD) have high risk of cardiovascular events due to the remodeling of the heart and vessels. We investigated whether in COPD cardiac remodeling is associated with immune response to the inflammation by studying activated T-lymphocytes, CD3+, CD4+, CD8+ subsets of T-lymphocytes autoimmune lymphocytotoxic and granulocytotoxic antibodies, circulating immune complexes, bacterial sensibilization and hypersensitivity by the delayed type to the host heart tissue antigens. It turned out that progression of COPD is characterized by the decrease of cell immunity with formation of bacterial sensibilization and autosensibilization to the heart tissue antigens, strongly associated with cardiac remodeling. Thus, the presence of autoimmune response significantly contributes to the changes of heart geometry in patients with COPD.Dielievska V.Kravchun P.Sciendoarticleleukocyte migration inhibitory factorremodeling of the left ventriclebacterial sensibilizationautoimmune lymphocytotoxic antibodiesMedicineRENActa Medica Bulgarica, Vol 44, Iss 1, Pp 11-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	leukocyte migration inhibitory factor remodeling of the left ventricle bacterial sensibilization autoimmune lymphocytotoxic antibodies Medicine R
spellingShingle	leukocyte migration inhibitory factor remodeling of the left ventricle bacterial sensibilization autoimmune lymphocytotoxic antibodies Medicine R Dielievska V. Kravchun P. Autoimmune Mechanisms of Cardiac Remodeling in Chronic Obstructive Pulmonary Disease
description	Patients with chronic obstructive pulmonary disease (COPD) have high risk of cardiovascular events due to the remodeling of the heart and vessels. We investigated whether in COPD cardiac remodeling is associated with immune response to the inflammation by studying activated T-lymphocytes, CD3+, CD4+, CD8+ subsets of T-lymphocytes autoimmune lymphocytotoxic and granulocytotoxic antibodies, circulating immune complexes, bacterial sensibilization and hypersensitivity by the delayed type to the host heart tissue antigens. It turned out that progression of COPD is characterized by the decrease of cell immunity with formation of bacterial sensibilization and autosensibilization to the heart tissue antigens, strongly associated with cardiac remodeling. Thus, the presence of autoimmune response significantly contributes to the changes of heart geometry in patients with COPD.
format	article
author	Dielievska V. Kravchun P.
author_facet	Dielievska V. Kravchun P.
author_sort	Dielievska V.
title	Autoimmune Mechanisms of Cardiac Remodeling in Chronic Obstructive Pulmonary Disease
title_short	Autoimmune Mechanisms of Cardiac Remodeling in Chronic Obstructive Pulmonary Disease
title_full	Autoimmune Mechanisms of Cardiac Remodeling in Chronic Obstructive Pulmonary Disease
title_fullStr	Autoimmune Mechanisms of Cardiac Remodeling in Chronic Obstructive Pulmonary Disease
title_full_unstemmed	Autoimmune Mechanisms of Cardiac Remodeling in Chronic Obstructive Pulmonary Disease
title_sort	autoimmune mechanisms of cardiac remodeling in chronic obstructive pulmonary disease
publisher	Sciendo
publishDate	2017
url	https://doaj.org/article/b59c5bf955864839a9b024322baaac82
work_keys_str_mv	AT dielievskav autoimmunemechanismsofcardiacremodelinginchronicobstructivepulmonarydisease AT kravchunp autoimmunemechanismsofcardiacremodelinginchronicobstructivepulmonarydisease
_version_	1718377111013556224

Autoimmune Mechanisms of Cardiac Remodeling in Chronic Obstructive Pulmonary Disease

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