Association between clinical and environmental factors and the gut microbiota profiles in young South African children

Abstract Differences in the microbiota in populations over age and geographical locations complicate cross-study comparisons, and it is therefore essential to describe the baseline or control microbiota in each population. This includes the determination of the influence of demographic, clinical and...

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Autores principales:	Kristien Nel Van Zyl, Andrew C. Whitelaw, Anneke C. Hesseling, James A. Seddon, Anne-Marie Demers, Mae Newton-Foot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b59d0d62cfdc4bb8bc8ba10771458834
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spelling	oai:doaj.org-article:b59d0d62cfdc4bb8bc8ba107714588342021-12-02T18:49:27ZAssociation between clinical and environmental factors and the gut microbiota profiles in young South African children10.1038/s41598-021-95409-52045-2322https://doaj.org/article/b59d0d62cfdc4bb8bc8ba107714588342021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95409-5https://doaj.org/toc/2045-2322Abstract Differences in the microbiota in populations over age and geographical locations complicate cross-study comparisons, and it is therefore essential to describe the baseline or control microbiota in each population. This includes the determination of the influence of demographic, clinical and environmental factors on the microbiota in a setting, and elucidates possible bias introduced by these factors, prior to further investigations. Little is known about the microbiota of children in South Africa after infancy. We provide a detailed description of the gut microbiota profiles of children from urban Cape Town and describe the influences of various clinical and environmental factors in different age groups during the first 5 years of life. Prevotella was the most common genus identified in the participants, and after infancy, the gut bacteria were dominated by Firmicutes and Bacteroidetes. In this setting, children exposed to antibiotics and indoor cooking fires were at the most risk for dysbiosis, showing significant losses in gut bacterial diversity.Kristien Nel Van ZylAndrew C. WhitelawAnneke C. HesselingJames A. SeddonAnne-Marie DemersMae Newton-FootNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kristien Nel Van Zyl Andrew C. Whitelaw Anneke C. Hesseling James A. Seddon Anne-Marie Demers Mae Newton-Foot Association between clinical and environmental factors and the gut microbiota profiles in young South African children
description	Abstract Differences in the microbiota in populations over age and geographical locations complicate cross-study comparisons, and it is therefore essential to describe the baseline or control microbiota in each population. This includes the determination of the influence of demographic, clinical and environmental factors on the microbiota in a setting, and elucidates possible bias introduced by these factors, prior to further investigations. Little is known about the microbiota of children in South Africa after infancy. We provide a detailed description of the gut microbiota profiles of children from urban Cape Town and describe the influences of various clinical and environmental factors in different age groups during the first 5 years of life. Prevotella was the most common genus identified in the participants, and after infancy, the gut bacteria were dominated by Firmicutes and Bacteroidetes. In this setting, children exposed to antibiotics and indoor cooking fires were at the most risk for dysbiosis, showing significant losses in gut bacterial diversity.
format	article
author	Kristien Nel Van Zyl Andrew C. Whitelaw Anneke C. Hesseling James A. Seddon Anne-Marie Demers Mae Newton-Foot
author_facet	Kristien Nel Van Zyl Andrew C. Whitelaw Anneke C. Hesseling James A. Seddon Anne-Marie Demers Mae Newton-Foot
author_sort	Kristien Nel Van Zyl
title	Association between clinical and environmental factors and the gut microbiota profiles in young South African children
title_short	Association between clinical and environmental factors and the gut microbiota profiles in young South African children
title_full	Association between clinical and environmental factors and the gut microbiota profiles in young South African children
title_fullStr	Association between clinical and environmental factors and the gut microbiota profiles in young South African children
title_full_unstemmed	Association between clinical and environmental factors and the gut microbiota profiles in young South African children
title_sort	association between clinical and environmental factors and the gut microbiota profiles in young south african children
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b59d0d62cfdc4bb8bc8ba10771458834
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Association between clinical and environmental factors and the gut microbiota profiles in young South African children

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