Fertility Preservation: How to Preserve Ovarian Function in Children, Adolescents and Adults

Chemotherapy, pelvic radiotherapy and ovarian surgery have known gonadotoxic effects that can lead to endocrine dysfunction, cessation of ovarian endocrine activity and early depletion of the ovarian reserve, causing a risk for future fertility problems, even in children. Important determinants of t...

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Autores principales:	Marie-Madeleine Dolmans, Camille Hossay, Thu Yen Thi Nguyen, Catherine Poirot
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	fertility preservation oocyte vitrification ovarian tissue cryopreservation cancer patients pediatric patients Medicine R
Acceso en línea:	https://doaj.org/article/b59ee95a35444fff93d7064ba77dd3b6
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spelling	oai:doaj.org-article:b59ee95a35444fff93d7064ba77dd3b62021-11-25T18:00:51ZFertility Preservation: How to Preserve Ovarian Function in Children, Adolescents and Adults10.3390/jcm102252472077-0383https://doaj.org/article/b59ee95a35444fff93d7064ba77dd3b62021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5247https://doaj.org/toc/2077-0383Chemotherapy, pelvic radiotherapy and ovarian surgery have known gonadotoxic effects that can lead to endocrine dysfunction, cessation of ovarian endocrine activity and early depletion of the ovarian reserve, causing a risk for future fertility problems, even in children. Important determinants of this risk are the patient’s age and ovarian reserve, type of treatment and dose. When the risk of premature ovarian insufficiency is high, fertility preservation strategies must be offered to the patient. Furthermore, fertility preservation may sometimes be needed in conditions other than cancer, such as in non-malignant diseases or in patients seeking fertility preservation for personal reasons. Oocyte and/or embryo vitrification and ovarian tissue cryopreservation are the two methods currently endorsed by the American Society for Reproductive Medicine, yielding encouraging results in terms of pregnancy and live birth rates. The choice of one technique above the other depends mostly on the age and pubertal status of the patient, and personal and medical circumstances. This review focuses on the available fertility preservation techniques, their appropriateness according to patient age and their efficacy in terms of pregnancy and live birth rates.Marie-Madeleine DolmansCamille HossayThu Yen Thi NguyenCatherine PoirotMDPI AGarticlefertility preservationoocyte vitrificationovarian tissue cryopreservationcancer patientspediatric patientsMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5247, p 5247 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fertility preservation oocyte vitrification ovarian tissue cryopreservation cancer patients pediatric patients Medicine R
spellingShingle	fertility preservation oocyte vitrification ovarian tissue cryopreservation cancer patients pediatric patients Medicine R Marie-Madeleine Dolmans Camille Hossay Thu Yen Thi Nguyen Catherine Poirot Fertility Preservation: How to Preserve Ovarian Function in Children, Adolescents and Adults
description	Chemotherapy, pelvic radiotherapy and ovarian surgery have known gonadotoxic effects that can lead to endocrine dysfunction, cessation of ovarian endocrine activity and early depletion of the ovarian reserve, causing a risk for future fertility problems, even in children. Important determinants of this risk are the patient’s age and ovarian reserve, type of treatment and dose. When the risk of premature ovarian insufficiency is high, fertility preservation strategies must be offered to the patient. Furthermore, fertility preservation may sometimes be needed in conditions other than cancer, such as in non-malignant diseases or in patients seeking fertility preservation for personal reasons. Oocyte and/or embryo vitrification and ovarian tissue cryopreservation are the two methods currently endorsed by the American Society for Reproductive Medicine, yielding encouraging results in terms of pregnancy and live birth rates. The choice of one technique above the other depends mostly on the age and pubertal status of the patient, and personal and medical circumstances. This review focuses on the available fertility preservation techniques, their appropriateness according to patient age and their efficacy in terms of pregnancy and live birth rates.
format	article
author	Marie-Madeleine Dolmans Camille Hossay Thu Yen Thi Nguyen Catherine Poirot
author_facet	Marie-Madeleine Dolmans Camille Hossay Thu Yen Thi Nguyen Catherine Poirot
author_sort	Marie-Madeleine Dolmans
title	Fertility Preservation: How to Preserve Ovarian Function in Children, Adolescents and Adults
title_short	Fertility Preservation: How to Preserve Ovarian Function in Children, Adolescents and Adults
title_full	Fertility Preservation: How to Preserve Ovarian Function in Children, Adolescents and Adults
title_fullStr	Fertility Preservation: How to Preserve Ovarian Function in Children, Adolescents and Adults
title_full_unstemmed	Fertility Preservation: How to Preserve Ovarian Function in Children, Adolescents and Adults
title_sort	fertility preservation: how to preserve ovarian function in children, adolescents and adults
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b59ee95a35444fff93d7064ba77dd3b6
work_keys_str_mv	AT mariemadeleinedolmans fertilitypreservationhowtopreserveovarianfunctioninchildrenadolescentsandadults AT camillehossay fertilitypreservationhowtopreserveovarianfunctioninchildrenadolescentsandadults AT thuyenthinguyen fertilitypreservationhowtopreserveovarianfunctioninchildrenadolescentsandadults AT catherinepoirot fertilitypreservationhowtopreserveovarianfunctioninchildrenadolescentsandadults
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Fertility Preservation: How to Preserve Ovarian Function in Children, Adolescents and Adults

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