Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in Drosophila

Abstract Light is necessary for life, but prolonged exposure to artificial light is a matter of increasing health concern. Humans are exposed to increased amounts of light in the blue spectrum produced by light-emitting diodes (LEDs), which can interfere with normal sleep cycles. The LED technologie...

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Autores principales:	Trevor R. Nash, Eileen S. Chow, Alexander D. Law, Samuel D. Fu, Elzbieta Fuszara, Aleksandra Bilska, Piotr Bebas, Doris Kretzschmar, Jadwiga M. Giebultowicz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/b5a13df9da704333ac49a61936553663
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spelling	oai:doaj.org-article:b5a13df9da704333ac49a619365536632021-12-02T16:05:43ZDaily blue-light exposure shortens lifespan and causes brain neurodegeneration in Drosophila10.1038/s41514-019-0038-62056-3973https://doaj.org/article/b5a13df9da704333ac49a619365536632019-10-01T00:00:00Zhttps://doi.org/10.1038/s41514-019-0038-6https://doaj.org/toc/2056-3973Abstract Light is necessary for life, but prolonged exposure to artificial light is a matter of increasing health concern. Humans are exposed to increased amounts of light in the blue spectrum produced by light-emitting diodes (LEDs), which can interfere with normal sleep cycles. The LED technologies are relatively new; therefore, the long-term effects of exposure to blue light across the lifespan are not understood. We investigated the effects of light in the model organism, Drosophila melanogaster, and determined that flies maintained in daily cycles of 12-h blue LED and 12-h darkness had significantly reduced longevity compared with flies maintained in constant darkness or in white light with blue wavelengths blocked. Exposure of adult flies to 12 h of blue light per day accelerated aging phenotypes causing damage to retinal cells, brain neurodegeneration, and impaired locomotion. We report that brain damage and locomotor impairments do not depend on the degeneration in the retina, as these phenotypes were evident under blue light in flies with genetically ablated eyes. Blue light induces expression of stress-responsive genes in old flies but not in young, suggesting that cumulative light exposure acts as a stressor during aging. We also determined that several known blue-light-sensitive proteins are not acting in pathways mediating detrimental light effects. Our study reveals the unexpected effects of blue light on fly brain and establishes Drosophila as a model in which to investigate long-term effects of blue light at the cellular and organismal level.Trevor R. NashEileen S. ChowAlexander D. LawSamuel D. FuElzbieta FuszaraAleksandra BilskaPiotr BebasDoris KretzschmarJadwiga M. GiebultowiczNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 5, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Trevor R. Nash Eileen S. Chow Alexander D. Law Samuel D. Fu Elzbieta Fuszara Aleksandra Bilska Piotr Bebas Doris Kretzschmar Jadwiga M. Giebultowicz Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in Drosophila
description	Abstract Light is necessary for life, but prolonged exposure to artificial light is a matter of increasing health concern. Humans are exposed to increased amounts of light in the blue spectrum produced by light-emitting diodes (LEDs), which can interfere with normal sleep cycles. The LED technologies are relatively new; therefore, the long-term effects of exposure to blue light across the lifespan are not understood. We investigated the effects of light in the model organism, Drosophila melanogaster, and determined that flies maintained in daily cycles of 12-h blue LED and 12-h darkness had significantly reduced longevity compared with flies maintained in constant darkness or in white light with blue wavelengths blocked. Exposure of adult flies to 12 h of blue light per day accelerated aging phenotypes causing damage to retinal cells, brain neurodegeneration, and impaired locomotion. We report that brain damage and locomotor impairments do not depend on the degeneration in the retina, as these phenotypes were evident under blue light in flies with genetically ablated eyes. Blue light induces expression of stress-responsive genes in old flies but not in young, suggesting that cumulative light exposure acts as a stressor during aging. We also determined that several known blue-light-sensitive proteins are not acting in pathways mediating detrimental light effects. Our study reveals the unexpected effects of blue light on fly brain and establishes Drosophila as a model in which to investigate long-term effects of blue light at the cellular and organismal level.
format	article
author	Trevor R. Nash Eileen S. Chow Alexander D. Law Samuel D. Fu Elzbieta Fuszara Aleksandra Bilska Piotr Bebas Doris Kretzschmar Jadwiga M. Giebultowicz
author_facet	Trevor R. Nash Eileen S. Chow Alexander D. Law Samuel D. Fu Elzbieta Fuszara Aleksandra Bilska Piotr Bebas Doris Kretzschmar Jadwiga M. Giebultowicz
author_sort	Trevor R. Nash
title	Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in Drosophila
title_short	Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in Drosophila
title_full	Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in Drosophila
title_fullStr	Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in Drosophila
title_full_unstemmed	Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in Drosophila
title_sort	daily blue-light exposure shortens lifespan and causes brain neurodegeneration in drosophila
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b5a13df9da704333ac49a61936553663
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Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in Drosophila

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