Contribution of Dysregulated DNA Methylation to Autoimmunity

Epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs are known regulators of gene expression and genomic stability in cell growth, development, and differentiation. Because epigenetic mechanisms can regulate several immune system elements, epigenetic alterations...

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Autores principales:	Samanta C. Funes, Ayleen Fernández-Fierro, Diego Rebolledo-Zelada, Juan P. Mackern-Oberti, Alexis M. Kalergis
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	DNA methylation epigenetic systemic autoimmunity rheumatoid arthritis CpG Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b5a17a3ac5a947c3b0c7a432aa2ac972
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spelling	oai:doaj.org-article:b5a17a3ac5a947c3b0c7a432aa2ac9722021-11-11T17:19:22ZContribution of Dysregulated DNA Methylation to Autoimmunity10.3390/ijms2221118921422-00671661-6596https://doaj.org/article/b5a17a3ac5a947c3b0c7a432aa2ac9722021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11892https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs are known regulators of gene expression and genomic stability in cell growth, development, and differentiation. Because epigenetic mechanisms can regulate several immune system elements, epigenetic alterations have been found in several autoimmune diseases. The purpose of this review is to discuss the epigenetic modifications, mainly DNA methylation, involved in autoimmune diseases in which T cells play a significant role. For example, Rheumatoid Arthritis and Systemic Lupus Erythematosus display differential gene methylation, mostly hypomethylated 5′-C-phosphate-G-3′ (CpG) sites that may associate with disease activity. However, a clear association between DNA methylation, gene expression, and disease pathogenesis must be demonstrated. A better understanding of the impact of epigenetic modifications on the onset of autoimmunity will contribute to the design of novel therapeutic approaches for these diseases.Samanta C. FunesAyleen Fernández-FierroDiego Rebolledo-ZeladaJuan P. Mackern-ObertiAlexis M. KalergisMDPI AGarticleDNA methylationepigeneticsystemic autoimmunityrheumatoid arthritisCpGBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11892, p 11892 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	DNA methylation epigenetic systemic autoimmunity rheumatoid arthritis CpG Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	DNA methylation epigenetic systemic autoimmunity rheumatoid arthritis CpG Biology (General) QH301-705.5 Chemistry QD1-999 Samanta C. Funes Ayleen Fernández-Fierro Diego Rebolledo-Zelada Juan P. Mackern-Oberti Alexis M. Kalergis Contribution of Dysregulated DNA Methylation to Autoimmunity
description	Epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs are known regulators of gene expression and genomic stability in cell growth, development, and differentiation. Because epigenetic mechanisms can regulate several immune system elements, epigenetic alterations have been found in several autoimmune diseases. The purpose of this review is to discuss the epigenetic modifications, mainly DNA methylation, involved in autoimmune diseases in which T cells play a significant role. For example, Rheumatoid Arthritis and Systemic Lupus Erythematosus display differential gene methylation, mostly hypomethylated 5′-C-phosphate-G-3′ (CpG) sites that may associate with disease activity. However, a clear association between DNA methylation, gene expression, and disease pathogenesis must be demonstrated. A better understanding of the impact of epigenetic modifications on the onset of autoimmunity will contribute to the design of novel therapeutic approaches for these diseases.
format	article
author	Samanta C. Funes Ayleen Fernández-Fierro Diego Rebolledo-Zelada Juan P. Mackern-Oberti Alexis M. Kalergis
author_facet	Samanta C. Funes Ayleen Fernández-Fierro Diego Rebolledo-Zelada Juan P. Mackern-Oberti Alexis M. Kalergis
author_sort	Samanta C. Funes
title	Contribution of Dysregulated DNA Methylation to Autoimmunity
title_short	Contribution of Dysregulated DNA Methylation to Autoimmunity
title_full	Contribution of Dysregulated DNA Methylation to Autoimmunity
title_fullStr	Contribution of Dysregulated DNA Methylation to Autoimmunity
title_full_unstemmed	Contribution of Dysregulated DNA Methylation to Autoimmunity
title_sort	contribution of dysregulated dna methylation to autoimmunity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b5a17a3ac5a947c3b0c7a432aa2ac972
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Contribution of Dysregulated DNA Methylation to Autoimmunity

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