Crossroads between membrane trafficking machinery and copper homeostasis in the nerve system

Imbalanced copper homeostasis and perturbation of membrane trafficking are two common symptoms that have been associated with the pathogenesis of neurodegenerative and neurodevelopmental diseases. Accumulating evidence from biophysical, cellular and in vivo studies suggest that membrane trafficking...

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Autores principales:	Meng-Hsuan Wen, Xihong Xie, Pei-San Huang, Karen Yang, Tai-Yen Chen
Formato:	article
Lenguaje:	EN
Publicado:	The Royal Society 2021
Materias:	copper transporters membrane trafficking regulators neurodegenerative diseases CTR1 ATP7A/B Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b5a26894fbe942c19e4adf4b93d1aae0
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spelling	oai:doaj.org-article:b5a26894fbe942c19e4adf4b93d1aae02021-12-01T08:06:04ZCrossroads between membrane trafficking machinery and copper homeostasis in the nerve system10.1098/rsob.2101282046-2441https://doaj.org/article/b5a26894fbe942c19e4adf4b93d1aae02021-12-01T00:00:00Zhttps://royalsocietypublishing.org/doi/10.1098/rsob.210128https://doaj.org/toc/2046-2441Imbalanced copper homeostasis and perturbation of membrane trafficking are two common symptoms that have been associated with the pathogenesis of neurodegenerative and neurodevelopmental diseases. Accumulating evidence from biophysical, cellular and in vivo studies suggest that membrane trafficking orchestrates both copper homeostasis and neural functions—however, a systematic review of how copper homeostasis and membrane trafficking interplays in neurons remains lacking. Here, we summarize current knowledge of the general trafficking itineraries for copper transporters and highlight several critical membrane trafficking regulators in maintaining copper homeostasis. We discuss how membrane trafficking regulators may alter copper transporter distribution in different membrane compartments to regulate intracellular copper homeostasis. Using Parkinson's disease and MEDNIK as examples, we further elaborate how misregulated trafficking regulators may interplay parallelly or synergistically with copper dyshomeostasis in devastating pathogenesis in neurodegenerative diseases. Finally, we explore multiple unsolved questions and highlight the existing challenges to understand how copper homeostasis is modulated through membrane trafficking.Meng-Hsuan WenXihong XiePei-San HuangKaren YangTai-Yen ChenThe Royal Societyarticlecopper transportersmembrane trafficking regulatorsneurodegenerative diseasesCTR1ATP7A/BBiology (General)QH301-705.5ENOpen Biology, Vol 11, Iss 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	copper transporters membrane trafficking regulators neurodegenerative diseases CTR1 ATP7A/B Biology (General) QH301-705.5
spellingShingle	copper transporters membrane trafficking regulators neurodegenerative diseases CTR1 ATP7A/B Biology (General) QH301-705.5 Meng-Hsuan Wen Xihong Xie Pei-San Huang Karen Yang Tai-Yen Chen Crossroads between membrane trafficking machinery and copper homeostasis in the nerve system
description	Imbalanced copper homeostasis and perturbation of membrane trafficking are two common symptoms that have been associated with the pathogenesis of neurodegenerative and neurodevelopmental diseases. Accumulating evidence from biophysical, cellular and in vivo studies suggest that membrane trafficking orchestrates both copper homeostasis and neural functions—however, a systematic review of how copper homeostasis and membrane trafficking interplays in neurons remains lacking. Here, we summarize current knowledge of the general trafficking itineraries for copper transporters and highlight several critical membrane trafficking regulators in maintaining copper homeostasis. We discuss how membrane trafficking regulators may alter copper transporter distribution in different membrane compartments to regulate intracellular copper homeostasis. Using Parkinson's disease and MEDNIK as examples, we further elaborate how misregulated trafficking regulators may interplay parallelly or synergistically with copper dyshomeostasis in devastating pathogenesis in neurodegenerative diseases. Finally, we explore multiple unsolved questions and highlight the existing challenges to understand how copper homeostasis is modulated through membrane trafficking.
format	article
author	Meng-Hsuan Wen Xihong Xie Pei-San Huang Karen Yang Tai-Yen Chen
author_facet	Meng-Hsuan Wen Xihong Xie Pei-San Huang Karen Yang Tai-Yen Chen
author_sort	Meng-Hsuan Wen
title	Crossroads between membrane trafficking machinery and copper homeostasis in the nerve system
title_short	Crossroads between membrane trafficking machinery and copper homeostasis in the nerve system
title_full	Crossroads between membrane trafficking machinery and copper homeostasis in the nerve system
title_fullStr	Crossroads between membrane trafficking machinery and copper homeostasis in the nerve system
title_full_unstemmed	Crossroads between membrane trafficking machinery and copper homeostasis in the nerve system
title_sort	crossroads between membrane trafficking machinery and copper homeostasis in the nerve system
publisher	The Royal Society
publishDate	2021
url	https://doaj.org/article/b5a26894fbe942c19e4adf4b93d1aae0
work_keys_str_mv	AT menghsuanwen crossroadsbetweenmembranetraffickingmachineryandcopperhomeostasisinthenervesystem AT xihongxie crossroadsbetweenmembranetraffickingmachineryandcopperhomeostasisinthenervesystem AT peisanhuang crossroadsbetweenmembranetraffickingmachineryandcopperhomeostasisinthenervesystem AT karenyang crossroadsbetweenmembranetraffickingmachineryandcopperhomeostasisinthenervesystem AT taiyenchen crossroadsbetweenmembranetraffickingmachineryandcopperhomeostasisinthenervesystem
_version_	1718405435368669184

Crossroads between membrane trafficking machinery and copper homeostasis in the nerve system

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