Telomere dysfunction activates YAP1 to drive tissue inflammation
How telomere dysfunction is directly linked to inflammation in humans is currently unclear. Here the authors reveal that telomere dysfunction drives activation of the YAP1 transcription factor, up-regulating the pro inflammatory factor, pro-IL-18 thus revealing a link between telomere dysfunction an...
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Nature Portfolio
2020
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oai:doaj.org-article:b5a35bee98a746039f8bae57932486572021-12-02T15:15:23ZTelomere dysfunction activates YAP1 to drive tissue inflammation10.1038/s41467-020-18420-w2041-1723https://doaj.org/article/b5a35bee98a746039f8bae57932486572020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18420-whttps://doaj.org/toc/2041-1723How telomere dysfunction is directly linked to inflammation in humans is currently unclear. Here the authors reveal that telomere dysfunction drives activation of the YAP1 transcription factor, up-regulating the pro inflammatory factor, pro-IL-18 thus revealing a link between telomere dysfunction and initiation of intestinal inflammation.Deepavali ChakravartiBaoli HuXizeng MaoAsif RashidJiexi LiJun LiWen-ting LiaoElizabeth M. WhitleyPrasenjit DeyPingping HouKyle A. LaBellaAndrew ChangGuocan WangDenise J. SpringPingna DengDi ZhaoXin LiangZhengdao LanYiyun LinSharmistha SarkarChristopher TerranovaYonathan Lissanu DeribeSarah E. BluttPablo OkhuysenJianhua ZhangEduardo VilarOle Haagen NielsenAndrew DupontMamoun YounesKalyani R. PatelNoah F. ShroyerKunal RaiMary K. EstesY. Alan WangAlison A. BertuchRonald A. DePinhoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
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DOAJ |
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Science Q |
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Science Q Deepavali Chakravarti Baoli Hu Xizeng Mao Asif Rashid Jiexi Li Jun Li Wen-ting Liao Elizabeth M. Whitley Prasenjit Dey Pingping Hou Kyle A. LaBella Andrew Chang Guocan Wang Denise J. Spring Pingna Deng Di Zhao Xin Liang Zhengdao Lan Yiyun Lin Sharmistha Sarkar Christopher Terranova Yonathan Lissanu Deribe Sarah E. Blutt Pablo Okhuysen Jianhua Zhang Eduardo Vilar Ole Haagen Nielsen Andrew Dupont Mamoun Younes Kalyani R. Patel Noah F. Shroyer Kunal Rai Mary K. Estes Y. Alan Wang Alison A. Bertuch Ronald A. DePinho Telomere dysfunction activates YAP1 to drive tissue inflammation |
| description |
How telomere dysfunction is directly linked to inflammation in humans is currently unclear. Here the authors reveal that telomere dysfunction drives activation of the YAP1 transcription factor, up-regulating the pro inflammatory factor, pro-IL-18 thus revealing a link between telomere dysfunction and initiation of intestinal inflammation. |
| format |
article |
| author |
Deepavali Chakravarti Baoli Hu Xizeng Mao Asif Rashid Jiexi Li Jun Li Wen-ting Liao Elizabeth M. Whitley Prasenjit Dey Pingping Hou Kyle A. LaBella Andrew Chang Guocan Wang Denise J. Spring Pingna Deng Di Zhao Xin Liang Zhengdao Lan Yiyun Lin Sharmistha Sarkar Christopher Terranova Yonathan Lissanu Deribe Sarah E. Blutt Pablo Okhuysen Jianhua Zhang Eduardo Vilar Ole Haagen Nielsen Andrew Dupont Mamoun Younes Kalyani R. Patel Noah F. Shroyer Kunal Rai Mary K. Estes Y. Alan Wang Alison A. Bertuch Ronald A. DePinho |
| author_facet |
Deepavali Chakravarti Baoli Hu Xizeng Mao Asif Rashid Jiexi Li Jun Li Wen-ting Liao Elizabeth M. Whitley Prasenjit Dey Pingping Hou Kyle A. LaBella Andrew Chang Guocan Wang Denise J. Spring Pingna Deng Di Zhao Xin Liang Zhengdao Lan Yiyun Lin Sharmistha Sarkar Christopher Terranova Yonathan Lissanu Deribe Sarah E. Blutt Pablo Okhuysen Jianhua Zhang Eduardo Vilar Ole Haagen Nielsen Andrew Dupont Mamoun Younes Kalyani R. Patel Noah F. Shroyer Kunal Rai Mary K. Estes Y. Alan Wang Alison A. Bertuch Ronald A. DePinho |
| author_sort |
Deepavali Chakravarti |
| title |
Telomere dysfunction activates YAP1 to drive tissue inflammation |
| title_short |
Telomere dysfunction activates YAP1 to drive tissue inflammation |
| title_full |
Telomere dysfunction activates YAP1 to drive tissue inflammation |
| title_fullStr |
Telomere dysfunction activates YAP1 to drive tissue inflammation |
| title_full_unstemmed |
Telomere dysfunction activates YAP1 to drive tissue inflammation |
| title_sort |
telomere dysfunction activates yap1 to drive tissue inflammation |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/b5a35bee98a746039f8bae5793248657 |
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