Cerebral oxygen saturation: graded response to carbon dioxide with isoxia and graded response to oxygen with isocapnia.

<h4>Background</h4>Monitoring cerebral saturation is increasingly seen as an aid to management of patients in the operating room and in neurocritical care. How best to manipulate cerebral saturation is not fully known. We examined cerebral saturation with graded changes in carbon dioxide...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	W Alan C Mutch, Sunni R Patel, Ayda M Shahidi, Susith I Kulasekara, Joseph A Fisher, James Duffin, Christopher Hudson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b5a3cc9ac5264a24a691b6418d6255ba
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b5a3cc9ac5264a24a691b6418d6255ba
record_format	dspace
spelling	oai:doaj.org-article:b5a3cc9ac5264a24a691b6418d6255ba2021-11-18T07:55:22ZCerebral oxygen saturation: graded response to carbon dioxide with isoxia and graded response to oxygen with isocapnia.1932-620310.1371/journal.pone.0057881https://doaj.org/article/b5a3cc9ac5264a24a691b6418d6255ba2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23469096/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Monitoring cerebral saturation is increasingly seen as an aid to management of patients in the operating room and in neurocritical care. How best to manipulate cerebral saturation is not fully known. We examined cerebral saturation with graded changes in carbon dioxide tension while isoxic and with graded changes in oxygen tension while isocapnic.<h4>Methodology/principal findings</h4>The study was approved by the Research Ethics Board of the University Health Network at the University of Toronto. Thirteen studies were undertaken in healthy adults with cerebral oximetry by near infrared spectroscopy. End-tidal gas concentrations were manipulated using a model-based prospective end-tidal targeting device. End-tidal carbon dioxide was altered ±15 mmHg from baseline in 5 mmHg increments with isoxia (clamped at 110±4 mmHg). End-tidal oxygen was changed to 300, 400, 500, 80, 60 and 50 mmHg under isocapnia (37±2 mmHg). Twelve studies were completed. The end-tidal carbon dioxide versus cerebral saturation fit a linear relationship (R(2) = 0.92±0.06). The end-tidal oxygen versus cerebral saturation followed log-linear behaviour and best fit a hyperbolic relationship (R(2) = 0.85±0.10). Cerebral saturation was maximized in isoxia at end-tidal carbon dioxide of baseline +15 mmHg (77±3 percent). Cerebral saturation was minimal in isocapnia at an end-tidal oxygen tension of 50 mmHg (61±3 percent). The cerebral saturation during normoxic hypocapnia was equivalent to normocapnic hypoxia of 60 mmHg.<h4>Conclusions/significance</h4>Hypocapnia reduces cerebral saturation to an extent equivalent to moderate hypoxia.W Alan C MutchSunni R PatelAyda M ShahidiSusith I KulasekaraJoseph A FisherJames DuffinChristopher HudsonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e57881 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q W Alan C Mutch Sunni R Patel Ayda M Shahidi Susith I Kulasekara Joseph A Fisher James Duffin Christopher Hudson Cerebral oxygen saturation: graded response to carbon dioxide with isoxia and graded response to oxygen with isocapnia.
description	<h4>Background</h4>Monitoring cerebral saturation is increasingly seen as an aid to management of patients in the operating room and in neurocritical care. How best to manipulate cerebral saturation is not fully known. We examined cerebral saturation with graded changes in carbon dioxide tension while isoxic and with graded changes in oxygen tension while isocapnic.<h4>Methodology/principal findings</h4>The study was approved by the Research Ethics Board of the University Health Network at the University of Toronto. Thirteen studies were undertaken in healthy adults with cerebral oximetry by near infrared spectroscopy. End-tidal gas concentrations were manipulated using a model-based prospective end-tidal targeting device. End-tidal carbon dioxide was altered ±15 mmHg from baseline in 5 mmHg increments with isoxia (clamped at 110±4 mmHg). End-tidal oxygen was changed to 300, 400, 500, 80, 60 and 50 mmHg under isocapnia (37±2 mmHg). Twelve studies were completed. The end-tidal carbon dioxide versus cerebral saturation fit a linear relationship (R(2) = 0.92±0.06). The end-tidal oxygen versus cerebral saturation followed log-linear behaviour and best fit a hyperbolic relationship (R(2) = 0.85±0.10). Cerebral saturation was maximized in isoxia at end-tidal carbon dioxide of baseline +15 mmHg (77±3 percent). Cerebral saturation was minimal in isocapnia at an end-tidal oxygen tension of 50 mmHg (61±3 percent). The cerebral saturation during normoxic hypocapnia was equivalent to normocapnic hypoxia of 60 mmHg.<h4>Conclusions/significance</h4>Hypocapnia reduces cerebral saturation to an extent equivalent to moderate hypoxia.
format	article
author	W Alan C Mutch Sunni R Patel Ayda M Shahidi Susith I Kulasekara Joseph A Fisher James Duffin Christopher Hudson
author_facet	W Alan C Mutch Sunni R Patel Ayda M Shahidi Susith I Kulasekara Joseph A Fisher James Duffin Christopher Hudson
author_sort	W Alan C Mutch
title	Cerebral oxygen saturation: graded response to carbon dioxide with isoxia and graded response to oxygen with isocapnia.
title_short	Cerebral oxygen saturation: graded response to carbon dioxide with isoxia and graded response to oxygen with isocapnia.
title_full	Cerebral oxygen saturation: graded response to carbon dioxide with isoxia and graded response to oxygen with isocapnia.
title_fullStr	Cerebral oxygen saturation: graded response to carbon dioxide with isoxia and graded response to oxygen with isocapnia.
title_full_unstemmed	Cerebral oxygen saturation: graded response to carbon dioxide with isoxia and graded response to oxygen with isocapnia.
title_sort	cerebral oxygen saturation: graded response to carbon dioxide with isoxia and graded response to oxygen with isocapnia.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/b5a3cc9ac5264a24a691b6418d6255ba
work_keys_str_mv	AT walancmutch cerebraloxygensaturationgradedresponsetocarbondioxidewithisoxiaandgradedresponsetooxygenwithisocapnia AT sunnirpatel cerebraloxygensaturationgradedresponsetocarbondioxidewithisoxiaandgradedresponsetooxygenwithisocapnia AT aydamshahidi cerebraloxygensaturationgradedresponsetocarbondioxidewithisoxiaandgradedresponsetooxygenwithisocapnia AT susithikulasekara cerebraloxygensaturationgradedresponsetocarbondioxidewithisoxiaandgradedresponsetooxygenwithisocapnia AT josephafisher cerebraloxygensaturationgradedresponsetocarbondioxidewithisoxiaandgradedresponsetooxygenwithisocapnia AT jamesduffin cerebraloxygensaturationgradedresponsetocarbondioxidewithisoxiaandgradedresponsetooxygenwithisocapnia AT christopherhudson cerebraloxygensaturationgradedresponsetocarbondioxidewithisoxiaandgradedresponsetooxygenwithisocapnia
_version_	1718422752037175296

Cerebral oxygen saturation: graded response to carbon dioxide with isoxia and graded response to oxygen with isocapnia.

Ejemplares similares