Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation

Abstract Catheter ablation is an important non-pharmacological intervention for atrial fibrillation (AF), but its effect on the incidence of asymptomatic cerebral emboli and long-term effects on cognitive function remain unknown. We prospectively enrolled 101 patients who underwent AF ablation. Brai...

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Autores principales:	Natsuko Kato, Kanako Muraga, Yoshinori Hirata, Akihiro Shindo, Keita Matsuura, Yuichiro Ii, Mariko Shiga, Ken-ichi Tabei, Masayuki Satoh, Satoshi Fujita, Tomoyuki Fukuma, Yoshihiko Kagawa, Eitaro Fujii, Maki Umino, Masayuki Maeda, Hajime Sakuma, Masaaki Ito, Hidekazu Tomimoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b5a474dd8ac844efbe646794c1e44c5c
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spelling	oai:doaj.org-article:b5a474dd8ac844efbe646794c1e44c5c2021-12-02T15:14:27ZBrain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation10.1038/s41598-021-98484-w2045-2322https://doaj.org/article/b5a474dd8ac844efbe646794c1e44c5c2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98484-whttps://doaj.org/toc/2045-2322Abstract Catheter ablation is an important non-pharmacological intervention for atrial fibrillation (AF), but its effect on the incidence of asymptomatic cerebral emboli and long-term effects on cognitive function remain unknown. We prospectively enrolled 101 patients who underwent AF ablation. Brain magnetic resonance imaging (MRI) (72 patients) and neuropsychological assessments (66 patients) were performed 1–3 days (baseline) and 6 months after ablation. Immediately after ablation, diffusion-weighted MRI and 3-dimensional double inversion recovery (3D-DIR) detected embolic microinfarctions in 63 patients (87.5%) and 62 patients (86.1%), respectively. After 6 months, DIR lesions disappeared in 41 patients. Microbleeds (MBs) increased by 17%, and 65% of the de novo MBs were exactly at the same location as the microinfarctions. Average Mini-Mental State Examination scores improved from 27.9 ± 2.4 to 28.5 ± 1.7 (p = 0.037), and detailed neuropsychological assessment scores showed improvement in memory, constructional, and frontal lobe functions. Ejection fraction, left atrial volume index and brain natriuretic peptide level improved from baseline to 3–6 months after ablation. Despite incidental microemboli, cognitive function was preserved 6 months after ablation.Natsuko KatoKanako MuragaYoshinori HirataAkihiro ShindoKeita MatsuuraYuichiro IiMariko ShigaKen-ichi TabeiMasayuki SatohSatoshi FujitaTomoyuki FukumaYoshihiko KagawaEitaro FujiiMaki UminoMasayuki MaedaHajime SakumaMasaaki ItoHidekazu TomimotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Natsuko Kato Kanako Muraga Yoshinori Hirata Akihiro Shindo Keita Matsuura Yuichiro Ii Mariko Shiga Ken-ichi Tabei Masayuki Satoh Satoshi Fujita Tomoyuki Fukuma Yoshihiko Kagawa Eitaro Fujii Maki Umino Masayuki Maeda Hajime Sakuma Masaaki Ito Hidekazu Tomimoto Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation
description	Abstract Catheter ablation is an important non-pharmacological intervention for atrial fibrillation (AF), but its effect on the incidence of asymptomatic cerebral emboli and long-term effects on cognitive function remain unknown. We prospectively enrolled 101 patients who underwent AF ablation. Brain magnetic resonance imaging (MRI) (72 patients) and neuropsychological assessments (66 patients) were performed 1–3 days (baseline) and 6 months after ablation. Immediately after ablation, diffusion-weighted MRI and 3-dimensional double inversion recovery (3D-DIR) detected embolic microinfarctions in 63 patients (87.5%) and 62 patients (86.1%), respectively. After 6 months, DIR lesions disappeared in 41 patients. Microbleeds (MBs) increased by 17%, and 65% of the de novo MBs were exactly at the same location as the microinfarctions. Average Mini-Mental State Examination scores improved from 27.9 ± 2.4 to 28.5 ± 1.7 (p = 0.037), and detailed neuropsychological assessment scores showed improvement in memory, constructional, and frontal lobe functions. Ejection fraction, left atrial volume index and brain natriuretic peptide level improved from baseline to 3–6 months after ablation. Despite incidental microemboli, cognitive function was preserved 6 months after ablation.
format	article
author	Natsuko Kato Kanako Muraga Yoshinori Hirata Akihiro Shindo Keita Matsuura Yuichiro Ii Mariko Shiga Ken-ichi Tabei Masayuki Satoh Satoshi Fujita Tomoyuki Fukuma Yoshihiko Kagawa Eitaro Fujii Maki Umino Masayuki Maeda Hajime Sakuma Masaaki Ito Hidekazu Tomimoto
author_facet	Natsuko Kato Kanako Muraga Yoshinori Hirata Akihiro Shindo Keita Matsuura Yuichiro Ii Mariko Shiga Ken-ichi Tabei Masayuki Satoh Satoshi Fujita Tomoyuki Fukuma Yoshihiko Kagawa Eitaro Fujii Maki Umino Masayuki Maeda Hajime Sakuma Masaaki Ito Hidekazu Tomimoto
author_sort	Natsuko Kato
title	Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation
title_short	Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation
title_full	Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation
title_fullStr	Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation
title_full_unstemmed	Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation
title_sort	brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b5a474dd8ac844efbe646794c1e44c5c
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Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation

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