Prognostic role of Glasgow prognostic score in patients with colorectal cancer: evidence from population studies

Abstract Glasgow prognostic score (GPS) has been reported to be an indicator of prognosis for various cancers. However, the relationship between GPS and colorectal cancers (CRC) remains unclear. A comprehensive search of Pubmed, Embase, Cochrane library, Web of Science, ChinaInfo and Chinese Nationa...

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Autores principales:	Yangyang Liu, Xingkang He, Jie Pan, Shujie Chen, Liangjing Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b5a60597f18a468e93f7e2d3ce18762e
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spelling	oai:doaj.org-article:b5a60597f18a468e93f7e2d3ce18762e2021-12-02T16:07:01ZPrognostic role of Glasgow prognostic score in patients with colorectal cancer: evidence from population studies10.1038/s41598-017-06577-22045-2322https://doaj.org/article/b5a60597f18a468e93f7e2d3ce18762e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06577-2https://doaj.org/toc/2045-2322Abstract Glasgow prognostic score (GPS) has been reported to be an indicator of prognosis for various cancers. However, the relationship between GPS and colorectal cancers (CRC) remains unclear. A comprehensive search of Pubmed, Embase, Cochrane library, Web of Science, ChinaInfo and Chinese National Knowledge Infrastructure was performed to identify eligible studies, from which the risk of overall survival (OS) and cancer-specific survival (CSS) were extracted. A random-effect model was adopted to combine hazard ratio (HR) and 95% confidence interval (CI). 25 articles with a total of 5660 participants were included. The pooled results indicated that elevated GPS was associated with poor OS (HR = 2.83, 95%CI: 2.00–4.00, P < 0.01) and CSS (HR = 1.94, 95%CI: 1.51–2.49, P < 0.01). This correlation was confirmed both in primary operable and advanced inoperable patients. Increased GPS was also closely related to advanced tumour-node-metastasis (TNM) stage (odds ratio [OR] = 1.44, 95% CI: 1.010–2.065, P < 0.05) and elevated level of serum carcinoembryonic antigen (OR = 2.252, 95% CI: 1.508–3.362, P < 0.01). Subgroup analysis revealed a significant association between high GPS and poor survival outcome according to the factors of sample size, study of region and cut-off value of GPS level. These findings suggest that GPS may serve as a reliable predictive index for patients with CRC.Yangyang LiuXingkang HeJie PanShujie ChenLiangjing WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yangyang Liu Xingkang He Jie Pan Shujie Chen Liangjing Wang Prognostic role of Glasgow prognostic score in patients with colorectal cancer: evidence from population studies
description	Abstract Glasgow prognostic score (GPS) has been reported to be an indicator of prognosis for various cancers. However, the relationship between GPS and colorectal cancers (CRC) remains unclear. A comprehensive search of Pubmed, Embase, Cochrane library, Web of Science, ChinaInfo and Chinese National Knowledge Infrastructure was performed to identify eligible studies, from which the risk of overall survival (OS) and cancer-specific survival (CSS) were extracted. A random-effect model was adopted to combine hazard ratio (HR) and 95% confidence interval (CI). 25 articles with a total of 5660 participants were included. The pooled results indicated that elevated GPS was associated with poor OS (HR = 2.83, 95%CI: 2.00–4.00, P < 0.01) and CSS (HR = 1.94, 95%CI: 1.51–2.49, P < 0.01). This correlation was confirmed both in primary operable and advanced inoperable patients. Increased GPS was also closely related to advanced tumour-node-metastasis (TNM) stage (odds ratio [OR] = 1.44, 95% CI: 1.010–2.065, P < 0.05) and elevated level of serum carcinoembryonic antigen (OR = 2.252, 95% CI: 1.508–3.362, P < 0.01). Subgroup analysis revealed a significant association between high GPS and poor survival outcome according to the factors of sample size, study of region and cut-off value of GPS level. These findings suggest that GPS may serve as a reliable predictive index for patients with CRC.
format	article
author	Yangyang Liu Xingkang He Jie Pan Shujie Chen Liangjing Wang
author_facet	Yangyang Liu Xingkang He Jie Pan Shujie Chen Liangjing Wang
author_sort	Yangyang Liu
title	Prognostic role of Glasgow prognostic score in patients with colorectal cancer: evidence from population studies
title_short	Prognostic role of Glasgow prognostic score in patients with colorectal cancer: evidence from population studies
title_full	Prognostic role of Glasgow prognostic score in patients with colorectal cancer: evidence from population studies
title_fullStr	Prognostic role of Glasgow prognostic score in patients with colorectal cancer: evidence from population studies
title_full_unstemmed	Prognostic role of Glasgow prognostic score in patients with colorectal cancer: evidence from population studies
title_sort	prognostic role of glasgow prognostic score in patients with colorectal cancer: evidence from population studies
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b5a60597f18a468e93f7e2d3ce18762e
work_keys_str_mv	AT yangyangliu prognosticroleofglasgowprognosticscoreinpatientswithcolorectalcancerevidencefrompopulationstudies AT xingkanghe prognosticroleofglasgowprognosticscoreinpatientswithcolorectalcancerevidencefrompopulationstudies AT jiepan prognosticroleofglasgowprognosticscoreinpatientswithcolorectalcancerevidencefrompopulationstudies AT shujiechen prognosticroleofglasgowprognosticscoreinpatientswithcolorectalcancerevidencefrompopulationstudies AT liangjingwang prognosticroleofglasgowprognosticscoreinpatientswithcolorectalcancerevidencefrompopulationstudies
_version_	1718384800685883392

Prognostic role of Glasgow prognostic score in patients with colorectal cancer: evidence from population studies

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