Obesity and the development of type 2 diabetes: the effects of fatty tissue inflammation

Dara P SchusterDepartments of Internal Medicine and Surgery, Divisions of Endocrinology and Metabolism and Gastrointestinal Surgery, The Ohio State University Hospitals and Children&rsquo;s Hospital, Columbus, Ohio, USAAbstract: Obesity is a worldwide epidemic with multiple obesity-associate...

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Autor principal:	Dara P Schuster
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/b5a726de5b70441088cad25fa110650f
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spelling	oai:doaj.org-article:b5a726de5b70441088cad25fa110650f2021-12-02T06:50:13ZObesity and the development of type 2 diabetes: the effects of fatty tissue inflammation1178-7007https://doaj.org/article/b5a726de5b70441088cad25fa110650f2010-07-01T00:00:00Zhttp://www.dovepress.com/obesity-and-the-development-of-type-2-diabetes-the-effects-of-fatty-ti-a4864https://doaj.org/toc/1178-7007Dara P SchusterDepartments of Internal Medicine and Surgery, Divisions of Endocrinology and Metabolism and Gastrointestinal Surgery, The Ohio State University Hospitals and Children&rsquo;s Hospital, Columbus, Ohio, USAAbstract: Obesity is a worldwide epidemic with multiple obesity-associated health problems including type 2 diabetes, hypertension, and cardiovascular disease. Adipose tissue serves as a fuel storage depot, but also plays a pivotal role in homeostasis of energy expenditure, appetite regulation, glucose regulation, and immunity. Both genetics and environment play important roles in adipose tissue function and dysfunction. Obesity represents an abnormal accumulation of adipose tissue resulting from chronic overnutrition and reduced physical activity. The nature of this increased accumulation of fat tissue, whether hyperplasia or hypertrophy, local or ectopic, is associated with deleterious perturbations including excess fatty acid secretion, increased production of inflammatory cytokines, and abnormal adipocyte hormone signaling resulting in insulin resistance. In the setting of obesity, insulin resistance and chronic inflammation is postulated to play a role in development of type 2 diabetes and other obesity-related comorbidities including obstructive sleep apnea, hepatic steatosis, polycystic ovarian syndrome, hypertension and cardiovascular disease. Although the exact mechanism of these relationships are complex and not completely understood, the ability to store and limit fatty acid deposition to adipose tissue is a common component to remaining insulin sensitive, controlling the inflammatory cascade and reducing the risk of developing obesity-related comorbidities.Keywords: adipose tissue, inflammatory cascade, adipocyte, insulin resistance, glucose &not;regulation, healthy obese Dara P SchusterDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2010, Iss default, Pp 253-262 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Dara P Schuster Obesity and the development of type 2 diabetes: the effects of fatty tissue inflammation
description	Dara P SchusterDepartments of Internal Medicine and Surgery, Divisions of Endocrinology and Metabolism and Gastrointestinal Surgery, The Ohio State University Hospitals and Children&rsquo;s Hospital, Columbus, Ohio, USAAbstract: Obesity is a worldwide epidemic with multiple obesity-associated health problems including type 2 diabetes, hypertension, and cardiovascular disease. Adipose tissue serves as a fuel storage depot, but also plays a pivotal role in homeostasis of energy expenditure, appetite regulation, glucose regulation, and immunity. Both genetics and environment play important roles in adipose tissue function and dysfunction. Obesity represents an abnormal accumulation of adipose tissue resulting from chronic overnutrition and reduced physical activity. The nature of this increased accumulation of fat tissue, whether hyperplasia or hypertrophy, local or ectopic, is associated with deleterious perturbations including excess fatty acid secretion, increased production of inflammatory cytokines, and abnormal adipocyte hormone signaling resulting in insulin resistance. In the setting of obesity, insulin resistance and chronic inflammation is postulated to play a role in development of type 2 diabetes and other obesity-related comorbidities including obstructive sleep apnea, hepatic steatosis, polycystic ovarian syndrome, hypertension and cardiovascular disease. Although the exact mechanism of these relationships are complex and not completely understood, the ability to store and limit fatty acid deposition to adipose tissue is a common component to remaining insulin sensitive, controlling the inflammatory cascade and reducing the risk of developing obesity-related comorbidities.Keywords: adipose tissue, inflammatory cascade, adipocyte, insulin resistance, glucose &not;regulation, healthy obese
format	article
author	Dara P Schuster
author_facet	Dara P Schuster
author_sort	Dara P Schuster
title	Obesity and the development of type 2 diabetes: the effects of fatty tissue inflammation
title_short	Obesity and the development of type 2 diabetes: the effects of fatty tissue inflammation
title_full	Obesity and the development of type 2 diabetes: the effects of fatty tissue inflammation
title_fullStr	Obesity and the development of type 2 diabetes: the effects of fatty tissue inflammation
title_full_unstemmed	Obesity and the development of type 2 diabetes: the effects of fatty tissue inflammation
title_sort	obesity and the development of type 2 diabetes: the effects of fatty tissue inflammation
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/b5a726de5b70441088cad25fa110650f
work_keys_str_mv	AT darapschuster obesityandthedevelopmentoftype2diabetestheeffectsoffattytissueinflammation
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Obesity and the development of type 2 diabetes: the effects of fatty tissue inflammation

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