Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review

<i>Background and objectives</i>: Rosai–Dorfman disease (RDD) is a type of histiocytosis that usually appears in young adults or children as bilateral cervical lymphadenopathy, but extranodal involvement in not uncommon. Although the pathogenesis is not entirely elucidated, recent studie...

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Auteurs principaux:	George Iancu, Nicolae Gica, Laura Mihaela Mustata, Anca Maria Panaitescu, Danut Vasile, Gheorghe Peltecu
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	Rosai–Dorfman disease Rosai–Dorfman of breast breast pathology histiocytosis Medicine (General) R5-920
Accès en ligne:	https://doaj.org/article/b5ab850e346e459a802980605cbcc9b4
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spelling	oai:doaj.org-article:b5ab850e346e459a802980605cbcc9b42021-11-25T18:18:15ZRosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review10.3390/medicina571111671648-91441010-660Xhttps://doaj.org/article/b5ab850e346e459a802980605cbcc9b42021-10-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1167https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144<i>Background and objectives</i>: Rosai–Dorfman disease (RDD) is a type of histiocytosis that usually appears in young adults or children as bilateral cervical lymphadenopathy, but extranodal involvement in not uncommon. Although the pathogenesis is not entirely elucidated, recent studies showed a possible neoplastic process. <i>Materials and methods</i>: Our manuscript presents a rare case of Rosai–Dorfman disease of the breast, the management of this rare case, and a literature review. There are few cases reported of RDD of the breast (around 90 globally reported cases); the data is poor, and the management not yet standardized for these cases. The case reported here shows the importance of correct breast investigation, breast imaging, and ultrasound-guided biopsy that provided an accurate diagnosis and guided further management. <i>Results</i>: Although RDD of the breast was rarely presented as bilateral disease in other case reports, our case showed bilateral breast disease with the suspicion of breast cancer on imaging. Pathology and immunohistochemistry were of critical importance and showed a specific pattern for histiocytosis. A multidisciplinary approach was taken into consideration for these cases in order to establish the approach. Some patients underwent surgery, but watchful waiting and close follow-up were the preferred approach. <i>Conclusions</i>: RDD of the breast is a rare form of histiocytosis, with fewer than 100 globally published cases. Although the management of this disease is not established yet by guidelines, a follow-up approach should be enough for these patients, and surgery might be overtreatment. Mortality from RDD is very low due to comorbidities. A multidisciplinary team decision is important, and abstinence might significantly benefit these patients.George IancuNicolae GicaLaura Mihaela MustataAnca Maria PanaitescuDanut VasileGheorghe PeltecuMDPI AGarticleRosai–Dorfman diseaseRosai–Dorfman of breastbreast pathologyhistiocytosisMedicine (General)R5-920ENMedicina, Vol 57, Iss 1167, p 1167 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Rosai–Dorfman disease Rosai–Dorfman of breast breast pathology histiocytosis Medicine (General) R5-920
spellingShingle	Rosai–Dorfman disease Rosai–Dorfman of breast breast pathology histiocytosis Medicine (General) R5-920 George Iancu Nicolae Gica Laura Mihaela Mustata Anca Maria Panaitescu Danut Vasile Gheorghe Peltecu Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review
description	<i>Background and objectives</i>: Rosai–Dorfman disease (RDD) is a type of histiocytosis that usually appears in young adults or children as bilateral cervical lymphadenopathy, but extranodal involvement in not uncommon. Although the pathogenesis is not entirely elucidated, recent studies showed a possible neoplastic process. <i>Materials and methods</i>: Our manuscript presents a rare case of Rosai–Dorfman disease of the breast, the management of this rare case, and a literature review. There are few cases reported of RDD of the breast (around 90 globally reported cases); the data is poor, and the management not yet standardized for these cases. The case reported here shows the importance of correct breast investigation, breast imaging, and ultrasound-guided biopsy that provided an accurate diagnosis and guided further management. <i>Results</i>: Although RDD of the breast was rarely presented as bilateral disease in other case reports, our case showed bilateral breast disease with the suspicion of breast cancer on imaging. Pathology and immunohistochemistry were of critical importance and showed a specific pattern for histiocytosis. A multidisciplinary approach was taken into consideration for these cases in order to establish the approach. Some patients underwent surgery, but watchful waiting and close follow-up were the preferred approach. <i>Conclusions</i>: RDD of the breast is a rare form of histiocytosis, with fewer than 100 globally published cases. Although the management of this disease is not established yet by guidelines, a follow-up approach should be enough for these patients, and surgery might be overtreatment. Mortality from RDD is very low due to comorbidities. A multidisciplinary team decision is important, and abstinence might significantly benefit these patients.
format	article
author	George Iancu Nicolae Gica Laura Mihaela Mustata Anca Maria Panaitescu Danut Vasile Gheorghe Peltecu
author_facet	George Iancu Nicolae Gica Laura Mihaela Mustata Anca Maria Panaitescu Danut Vasile Gheorghe Peltecu
author_sort	George Iancu
title	Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review
title_short	Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review
title_full	Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review
title_fullStr	Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review
title_full_unstemmed	Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review
title_sort	rosai–dorfman disease: breast involvement—case report and literature review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b5ab850e346e459a802980605cbcc9b4
work_keys_str_mv	AT georgeiancu rosaidorfmandiseasebreastinvolvementcasereportandliteraturereview AT nicolaegica rosaidorfmandiseasebreastinvolvementcasereportandliteraturereview AT lauramihaelamustata rosaidorfmandiseasebreastinvolvementcasereportandliteraturereview AT ancamariapanaitescu rosaidorfmandiseasebreastinvolvementcasereportandliteraturereview AT danutvasile rosaidorfmandiseasebreastinvolvementcasereportandliteraturereview AT gheorghepeltecu rosaidorfmandiseasebreastinvolvementcasereportandliteraturereview
_version_	1718411402916397056

Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review

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