Type 2 Diabetes-Associated Genetic Polymorphisms as Potential Disease Predictors

Beska Z Witka,1 Dede J Oktaviani,1 Marcellino Marcellino,1 Melisa I Barliana,2,3 Rizky Abdulah1,3 1Departement of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia; 2Departement of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran...

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Autores principales:	Witka BZ, Oktaviani DJ, Marcellino M, Barliana MI, Abdulah R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	type 2 diabetes genetic polymorphisms susceptibility prediction. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/b5aea96483c647a498956a9cdfafc6d3
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spelling	oai:doaj.org-article:b5aea96483c647a498956a9cdfafc6d32021-12-02T02:52:39ZType 2 Diabetes-Associated Genetic Polymorphisms as Potential Disease Predictors1178-7007https://doaj.org/article/b5aea96483c647a498956a9cdfafc6d32019-12-01T00:00:00Zhttps://www.dovepress.com/type-2-diabetes-associated-genetic-polymorphisms-as-potential-disease--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Beska Z Witka,1 Dede J Oktaviani,1 Marcellino Marcellino,1 Melisa I Barliana,2,3 Rizky Abdulah1,3 1Departement of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia; 2Departement of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia; 3Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Jatinangor, IndonesiaCorrespondence: Melisa I BarlianaDepartment of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM. 21, Jatinangor 45363, IndonesiaEmail melisa.barliana@unpad.ac.idAbstract: Diabetes is a major cause of mortality worldwide. There are several types of diabetes, with type 2 diabetes mellitus (T2DM) being the most common. Many factors, including environmental and genetic factors, are involved in the etiology of the disease. Numerous studies have reported the role of genetic polymorphisms in the initiation and development of T2DM. While genome-wide association studies have identified around more than 200 susceptibility loci, it remains unclear whether these loci are correlated with the pathophysiology of the disease. The present review aimed to elucidate the potential genetic mechanisms underlying T2DM. We found that some genetic polymorphisms were related to T2DM, either in the form of single-nucleotide polymorphisms or direct amino acid changes in proteins. These polymorphisms are potential predictors for the management of T2DM.Keywords: type 2 diabetes, genetic polymorphisms, susceptibility predictionWitka BZOktaviani DJMarcellino MBarliana MIAbdulah RDove Medical Pressarticletype 2 diabetesgenetic polymorphismssusceptibility prediction.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 2689-2706 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 2 diabetes genetic polymorphisms susceptibility prediction. Specialties of internal medicine RC581-951
spellingShingle	type 2 diabetes genetic polymorphisms susceptibility prediction. Specialties of internal medicine RC581-951 Witka BZ Oktaviani DJ Marcellino M Barliana MI Abdulah R Type 2 Diabetes-Associated Genetic Polymorphisms as Potential Disease Predictors
description	Beska Z Witka,1 Dede J Oktaviani,1 Marcellino Marcellino,1 Melisa I Barliana,2,3 Rizky Abdulah1,3 1Departement of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia; 2Departement of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia; 3Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Jatinangor, IndonesiaCorrespondence: Melisa I BarlianaDepartment of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM. 21, Jatinangor 45363, IndonesiaEmail melisa.barliana@unpad.ac.idAbstract: Diabetes is a major cause of mortality worldwide. There are several types of diabetes, with type 2 diabetes mellitus (T2DM) being the most common. Many factors, including environmental and genetic factors, are involved in the etiology of the disease. Numerous studies have reported the role of genetic polymorphisms in the initiation and development of T2DM. While genome-wide association studies have identified around more than 200 susceptibility loci, it remains unclear whether these loci are correlated with the pathophysiology of the disease. The present review aimed to elucidate the potential genetic mechanisms underlying T2DM. We found that some genetic polymorphisms were related to T2DM, either in the form of single-nucleotide polymorphisms or direct amino acid changes in proteins. These polymorphisms are potential predictors for the management of T2DM.Keywords: type 2 diabetes, genetic polymorphisms, susceptibility prediction
format	article
author	Witka BZ Oktaviani DJ Marcellino M Barliana MI Abdulah R
author_facet	Witka BZ Oktaviani DJ Marcellino M Barliana MI Abdulah R
author_sort	Witka BZ
title	Type 2 Diabetes-Associated Genetic Polymorphisms as Potential Disease Predictors
title_short	Type 2 Diabetes-Associated Genetic Polymorphisms as Potential Disease Predictors
title_full	Type 2 Diabetes-Associated Genetic Polymorphisms as Potential Disease Predictors
title_fullStr	Type 2 Diabetes-Associated Genetic Polymorphisms as Potential Disease Predictors
title_full_unstemmed	Type 2 Diabetes-Associated Genetic Polymorphisms as Potential Disease Predictors
title_sort	type 2 diabetes-associated genetic polymorphisms as potential disease predictors
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/b5aea96483c647a498956a9cdfafc6d3
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Type 2 Diabetes-Associated Genetic Polymorphisms as Potential Disease Predictors

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