Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19

PEX19 is a chaperone and import receptor for peroxisomal membrane proteins (PMPs). Here the authors present the structure of the farnesylated C-terminal domain of PEX19, and its interaction with PMPs reveals how the farnesyl moiety allosterically reshapes the PMP binding surface and modulates PEX19...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Leonidas Emmanouilidis, Ulrike Schütz, Konstantinos Tripsianes, Tobias Madl, Juliane Radke, Robert Rucktäschel, Matthias Wilmanns, Wolfgang Schliebs, Ralf Erdmann, Michael Sattler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b5af4d4e62a8425b95894fbe959afdf2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b5af4d4e62a8425b95894fbe959afdf2
record_format	dspace
spelling	oai:doaj.org-article:b5af4d4e62a8425b95894fbe959afdf22021-12-02T14:42:33ZAllosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX1910.1038/ncomms146352041-1723https://doaj.org/article/b5af4d4e62a8425b95894fbe959afdf22017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14635https://doaj.org/toc/2041-1723PEX19 is a chaperone and import receptor for peroxisomal membrane proteins (PMPs). Here the authors present the structure of the farnesylated C-terminal domain of PEX19, and its interaction with PMPs reveals how the farnesyl moiety allosterically reshapes the PMP binding surface and modulates PEX19 function.Leonidas EmmanouilidisUlrike SchützKonstantinos TripsianesTobias MadlJuliane RadkeRobert RucktäschelMatthias WilmannsWolfgang SchliebsRalf ErdmannMichael SattlerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leonidas Emmanouilidis Ulrike Schütz Konstantinos Tripsianes Tobias Madl Juliane Radke Robert Rucktäschel Matthias Wilmanns Wolfgang Schliebs Ralf Erdmann Michael Sattler Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19
description	PEX19 is a chaperone and import receptor for peroxisomal membrane proteins (PMPs). Here the authors present the structure of the farnesylated C-terminal domain of PEX19, and its interaction with PMPs reveals how the farnesyl moiety allosterically reshapes the PMP binding surface and modulates PEX19 function.
format	article
author	Leonidas Emmanouilidis Ulrike Schütz Konstantinos Tripsianes Tobias Madl Juliane Radke Robert Rucktäschel Matthias Wilmanns Wolfgang Schliebs Ralf Erdmann Michael Sattler
author_facet	Leonidas Emmanouilidis Ulrike Schütz Konstantinos Tripsianes Tobias Madl Juliane Radke Robert Rucktäschel Matthias Wilmanns Wolfgang Schliebs Ralf Erdmann Michael Sattler
author_sort	Leonidas Emmanouilidis
title	Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19
title_short	Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19
title_full	Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19
title_fullStr	Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19
title_full_unstemmed	Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19
title_sort	allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor pex19
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b5af4d4e62a8425b95894fbe959afdf2
work_keys_str_mv	AT leonidasemmanouilidis allostericmodulationofperoxisomalmembraneproteinrecognitionbyfarnesylationoftheperoxisomalimportreceptorpex19 AT ulrikeschutz allostericmodulationofperoxisomalmembraneproteinrecognitionbyfarnesylationoftheperoxisomalimportreceptorpex19 AT konstantinostripsianes allostericmodulationofperoxisomalmembraneproteinrecognitionbyfarnesylationoftheperoxisomalimportreceptorpex19 AT tobiasmadl allostericmodulationofperoxisomalmembraneproteinrecognitionbyfarnesylationoftheperoxisomalimportreceptorpex19 AT julianeradke allostericmodulationofperoxisomalmembraneproteinrecognitionbyfarnesylationoftheperoxisomalimportreceptorpex19 AT robertrucktaschel allostericmodulationofperoxisomalmembraneproteinrecognitionbyfarnesylationoftheperoxisomalimportreceptorpex19 AT matthiaswilmanns allostericmodulationofperoxisomalmembraneproteinrecognitionbyfarnesylationoftheperoxisomalimportreceptorpex19 AT wolfgangschliebs allostericmodulationofperoxisomalmembraneproteinrecognitionbyfarnesylationoftheperoxisomalimportreceptorpex19 AT ralferdmann allostericmodulationofperoxisomalmembraneproteinrecognitionbyfarnesylationoftheperoxisomalimportreceptorpex19 AT michaelsattler allostericmodulationofperoxisomalmembraneproteinrecognitionbyfarnesylationoftheperoxisomalimportreceptorpex19
_version_	1718389654658482176

Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19

Ejemplares similares