Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother-infant pairs.

Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother-infant pairs.

<h4>Background</h4>Many maternal traits are associated with a neonate's gestational duration, birth weight, and birth length. These birth outcomes are subsequently associated with late-onset health conditions. The causal mechanisms and the relative contributions of maternal and feta...

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Autores principales: Jing Chen, Jonas Bacelis, Pol Sole-Navais, Amit Srivastava, Julius Juodakis, Amy Rouse, Mikko Hallman, Kari Teramo, Mads Melbye, Bjarke Feenstra, Rachel M Freathy, George Davey Smith, Deborah A Lawlor, Jeffrey C Murray, Scott M Williams, Bo Jacobsson, Louis J Muglia, Ge Zhang
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2020
Materias:
Medicine
R
Acceso en línea:https://doaj.org/article/b5bb6856719c4cbca033102f463bf5c0
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