Reversal of senescence-associated beta-galactosidase expression during in vitro three-dimensional tissue-engineering of human chondrocytes in a polymer scaffold

Abstract Regenerative medicine applications require cells that are not inflicted with senescence after in vitro culture for an optimal in vivo outcome. Methods to overcome replicative senescence include genomic modifications which have their own disadvantages. We have evaluated a three-dimensional (...

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Autores principales: Shojiro Katoh, Atsuki Fujimaru, Masaru Iwasaki, Hiroshi Yoshioka, Rajappa Senthilkumar, Senthilkumar Preethy, Samuel J. K. Abraham
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b5c0cbb496654a6aaf0d40704c94d2db
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