Managing fatigue in patients with primary Sjögren’s syndrome: challenges and solutions

Managing fatigue in patients with primary Sjögren’s syndrome: challenges and solutions

Samira Tatiyama Miyamoto,1 Dennis William Lendrem,2–4 Wan-Fai Ng,2–4 Katie Louise Hackett,2,4–5 Valéria Valim6,71Department of Integrated Education in Health, Universidade Federal do Espírito Santo, Vitória, Brazil; 2Musculoskeletal Rese...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Miyamoto ST, Lendrem DW, Ng WF, Hackett KL, Valim V
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
primary Sjögren’s syndrome
fatigue
treatment
review
Diseases of the musculoskeletal system
RC925-935
Acceso en línea:https://doaj.org/article/b5c1d78c51854764836146752cdfaae1
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:b5c1d78c51854764836146752cdfaae1
record_format dspace
spelling oai:doaj.org-article:b5c1d78c51854764836146752cdfaae12021-12-02T06:49:13ZManaging fatigue in patients with primary Sjögren’s syndrome: challenges and solutions1179-156Xhttps://doaj.org/article/b5c1d78c51854764836146752cdfaae12019-04-01T00:00:00Zhttps://www.dovepress.com/managing-fatigue-in-patients-with-primary-sjogrens-syndrome-challenges-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XSamira Tatiyama Miyamoto,1 Dennis William Lendrem,2–4 Wan-Fai Ng,2–4 Katie Louise Hackett,2,4–5 Valéria Valim6,71Department of Integrated Education in Health, Universidade Federal do Espírito Santo, Vitória, Brazil; 2Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University and NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK; 3NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK; 4Newcastle upon Tyne Hospitals NHS Trust, , Newcastle upon Tyne, UK; 5Department of Social Work, Education and Community Wellbeing, Northumbria University, Newcastle upon Tyne, UK; 6Department of Medical Clinic, Universidade Federal do Espírito Santo, Vitória, Brazil; 7Rheumatology Outpatient Clinic, Hospital Universitário Cassiano Antônio de Moraes (HUCAM), Vitória, BrazilAbstract: Primary Sjögren’s syndrome (pSS) patients identify fatigue as their most important symptom and the one most difficult to cope with, but there are still many challenges and few solutions to manage this debilitating symptom. Promising pharmacological treatments, such as rituximab, have failed in more stringent tests including randomized controlled trials (RCTs) and meta-analysis. While non-pharmacological interventions may be safer, less costly, and address other common comorbidities, to date only aerobic exercise seems to be effective at reducing fatigue in pSS. All interventions, pharmacological or not, need to be tested in high-quality RCTs. The aim of this review is to provide an overview of fatigue management in pSS and discuss potential opportunities for future research.Keywords: primary Sjögren’s syndrome, fatigue, treatment, reviewMiyamoto STLendrem DWNg WFHackett KLValim VDove Medical Pressarticleprimary Sjögren’s syndromefatiguetreatmentreviewDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 11, Pp 77-88 (2019)
institution DOAJ
collection DOAJ
language EN
topic primary Sjögren’s syndrome
fatigue
treatment
review
Diseases of the musculoskeletal system
RC925-935
spellingShingle primary Sjögren’s syndrome
fatigue
treatment
review
Diseases of the musculoskeletal system
RC925-935
Miyamoto ST
Lendrem DW
Ng WF
Hackett KL
Valim V
Managing fatigue in patients with primary Sjögren’s syndrome: challenges and solutions
description Samira Tatiyama Miyamoto,1 Dennis William Lendrem,2–4 Wan-Fai Ng,2–4 Katie Louise Hackett,2,4–5 Valéria Valim6,71Department of Integrated Education in Health, Universidade Federal do Espírito Santo, Vitória, Brazil; 2Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University and NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK; 3NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK; 4Newcastle upon Tyne Hospitals NHS Trust, , Newcastle upon Tyne, UK; 5Department of Social Work, Education and Community Wellbeing, Northumbria University, Newcastle upon Tyne, UK; 6Department of Medical Clinic, Universidade Federal do Espírito Santo, Vitória, Brazil; 7Rheumatology Outpatient Clinic, Hospital Universitário Cassiano Antônio de Moraes (HUCAM), Vitória, BrazilAbstract: Primary Sjögren’s syndrome (pSS) patients identify fatigue as their most important symptom and the one most difficult to cope with, but there are still many challenges and few solutions to manage this debilitating symptom. Promising pharmacological treatments, such as rituximab, have failed in more stringent tests including randomized controlled trials (RCTs) and meta-analysis. While non-pharmacological interventions may be safer, less costly, and address other common comorbidities, to date only aerobic exercise seems to be effective at reducing fatigue in pSS. All interventions, pharmacological or not, need to be tested in high-quality RCTs. The aim of this review is to provide an overview of fatigue management in pSS and discuss potential opportunities for future research.Keywords: primary Sjögren’s syndrome, fatigue, treatment, review
format article
author Miyamoto ST
Lendrem DW
Ng WF
Hackett KL
Valim V
author_facet Miyamoto ST
Lendrem DW
Ng WF
Hackett KL
Valim V
author_sort Miyamoto ST
title Managing fatigue in patients with primary Sjögren’s syndrome: challenges and solutions
title_short Managing fatigue in patients with primary Sjögren’s syndrome: challenges and solutions
title_full Managing fatigue in patients with primary Sjögren’s syndrome: challenges and solutions
title_fullStr Managing fatigue in patients with primary Sjögren’s syndrome: challenges and solutions
title_full_unstemmed Managing fatigue in patients with primary Sjögren’s syndrome: challenges and solutions
title_sort managing fatigue in patients with primary sjögren’s syndrome: challenges and solutions
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/b5c1d78c51854764836146752cdfaae1
work_keys_str_mv AT miyamotost managingfatigueinpatientswithprimarysjoumlgrenrsquossyndromechallengesandsolutions
AT lendremdw managingfatigueinpatientswithprimarysjoumlgrenrsquossyndromechallengesandsolutions
AT ngwf managingfatigueinpatientswithprimarysjoumlgrenrsquossyndromechallengesandsolutions
AT hackettkl managingfatigueinpatientswithprimarysjoumlgrenrsquossyndromechallengesandsolutions
AT valimv managingfatigueinpatientswithprimarysjoumlgrenrsquossyndromechallengesandsolutions
_version_ 1718399713114324992

Ejemplares similares