Hepatic sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic cell transplantation: historical and current considerations in Korea

Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a rare but severe complication of hematopoietic cell transplantation (HCT) showing high mortality. Multiple risk factors for SOS/VOD were identified, but it is often confused with other hepatic complications due to nonspecif...

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Autores principales:	Jae-Ho Yoon, Chul Won Choi, Jong-Ho Won
Formato:	article
Lenguaje:	EN
Publicado:	The Korean Association of Internal Medicine 2021
Materias:	hepatic veno-occlusive disease sinusoidal obstruction syndrome hematopoietic stem cell transplantation incidence treatment outcome Medicine R
Acceso en línea:	https://doaj.org/article/b5c3a5299f574b9799a82e068233f97c
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spelling	oai:doaj.org-article:b5c3a5299f574b9799a82e068233f97c2021-11-08T00:59:06ZHepatic sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic cell transplantation: historical and current considerations in Korea1226-33032005-664810.3904/kjim.2021.082https://doaj.org/article/b5c3a5299f574b9799a82e068233f97c2021-11-01T00:00:00Zhttp://www.kjim.org/upload/pdf/kjim-2021-082.pdfhttps://doaj.org/toc/1226-3303https://doaj.org/toc/2005-6648Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a rare but severe complication of hematopoietic cell transplantation (HCT) showing high mortality. Multiple risk factors for SOS/VOD were identified, but it is often confused with other hepatic complications due to nonspecific clinical features. Therefore, diagnostic and severity criteria have been revised several times. The European Society of Blood and Marrow Transplantation suggested a new guideline that excludes the standard duration of development within 21 days, emphasizes late-onset SOS/VOD, and suggests the importance of Doppler ultrasonography. The severity criteria were further subdivided for guidance to begin active treatment using defibrotide which was approved in Korea since 2016. In a phase 3 trial, defibrotide had superior 100-day survival, compared to best available treatments (38.2% vs. 25.0%). Although several studies of SOS/VOD in Korean patients have been performed after the implementation of HCT, most involved small number of pediatric patients. Recently, the Korean Society of Blood and Marrow Transplantation investigated the incidence of SOS/VOD in the Korean population, and several influential studies of adult patients were published. Here, we summarize recent issues regarding the mechanism, diagnosis, severity criteria, prevention, and treatments of SOS/VOD in Korean patients, as well as recent analyses of nationwide incidence.Jae-Ho YoonChul Won ChoiJong-Ho WonThe Korean Association of Internal Medicinearticlehepatic veno-occlusive diseasesinusoidal obstruction syndromehematopoietic stem cell transplantationincidencetreatment outcomeMedicineRENThe Korean Journal of Internal Medicine, Vol 36, Iss 3, Pp 1261-1280 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatic veno-occlusive disease sinusoidal obstruction syndrome hematopoietic stem cell transplantation incidence treatment outcome Medicine R
spellingShingle	hepatic veno-occlusive disease sinusoidal obstruction syndrome hematopoietic stem cell transplantation incidence treatment outcome Medicine R Jae-Ho Yoon Chul Won Choi Jong-Ho Won Hepatic sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic cell transplantation: historical and current considerations in Korea
description	Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a rare but severe complication of hematopoietic cell transplantation (HCT) showing high mortality. Multiple risk factors for SOS/VOD were identified, but it is often confused with other hepatic complications due to nonspecific clinical features. Therefore, diagnostic and severity criteria have been revised several times. The European Society of Blood and Marrow Transplantation suggested a new guideline that excludes the standard duration of development within 21 days, emphasizes late-onset SOS/VOD, and suggests the importance of Doppler ultrasonography. The severity criteria were further subdivided for guidance to begin active treatment using defibrotide which was approved in Korea since 2016. In a phase 3 trial, defibrotide had superior 100-day survival, compared to best available treatments (38.2% vs. 25.0%). Although several studies of SOS/VOD in Korean patients have been performed after the implementation of HCT, most involved small number of pediatric patients. Recently, the Korean Society of Blood and Marrow Transplantation investigated the incidence of SOS/VOD in the Korean population, and several influential studies of adult patients were published. Here, we summarize recent issues regarding the mechanism, diagnosis, severity criteria, prevention, and treatments of SOS/VOD in Korean patients, as well as recent analyses of nationwide incidence.
format	article
author	Jae-Ho Yoon Chul Won Choi Jong-Ho Won
author_facet	Jae-Ho Yoon Chul Won Choi Jong-Ho Won
author_sort	Jae-Ho Yoon
title	Hepatic sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic cell transplantation: historical and current considerations in Korea
title_short	Hepatic sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic cell transplantation: historical and current considerations in Korea
title_full	Hepatic sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic cell transplantation: historical and current considerations in Korea
title_fullStr	Hepatic sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic cell transplantation: historical and current considerations in Korea
title_full_unstemmed	Hepatic sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic cell transplantation: historical and current considerations in Korea
title_sort	hepatic sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic cell transplantation: historical and current considerations in korea
publisher	The Korean Association of Internal Medicine
publishDate	2021
url	https://doaj.org/article/b5c3a5299f574b9799a82e068233f97c
work_keys_str_mv	AT jaehoyoon hepaticsinusoidalobstructionsyndromevenoocclusivediseaseafterhematopoieticcelltransplantationhistoricalandcurrentconsiderationsinkorea AT chulwonchoi hepaticsinusoidalobstructionsyndromevenoocclusivediseaseafterhematopoieticcelltransplantationhistoricalandcurrentconsiderationsinkorea AT jonghowon hepaticsinusoidalobstructionsyndromevenoocclusivediseaseafterhematopoieticcelltransplantationhistoricalandcurrentconsiderationsinkorea
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Hepatic sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic cell transplantation: historical and current considerations in Korea

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