Gammaherpesvirus RNAs Come Full Circle

ABSTRACT After an adaptive immune response is mounted, gammaherpesviruses achieve persistence through the utilization of viral noncoding RNAs to craft a suitable host cell environment in an immunologically transparent manner. While gammaherpesvirus long noncoding RNAs (lncRNAs) and microRNAs have be...

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Autores principales:	Nathan A. Ungerleider, Scott A. Tibbetts, Rolf Renne, Erik K. Flemington
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	EBV KSHV MHV68 circRNA circular RNA gammaherpesvirus Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b5c5555eed2e45c4a86948e4d32461b7
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spelling	oai:doaj.org-article:b5c5555eed2e45c4a86948e4d32461b72021-11-15T15:55:26ZGammaherpesvirus RNAs Come Full Circle10.1128/mBio.00071-192150-7511https://doaj.org/article/b5c5555eed2e45c4a86948e4d32461b72019-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00071-19https://doaj.org/toc/2150-7511ABSTRACT After an adaptive immune response is mounted, gammaherpesviruses achieve persistence through the utilization of viral noncoding RNAs to craft a suitable host cell environment in an immunologically transparent manner. While gammaherpesvirus long noncoding RNAs (lncRNAs) and microRNAs have been recognized for some time and have been actively investigated, a recent spate of reports have now identified repertoires of the circular RNA (circRNA) class of noncoding RNAs in both the lymphocryptovirus and rhadinovirus genera of gammaherpesviruses. Despite the recent nature of these findings, the detection of circRNAs across viruses and viral gene expression programs, the conservation of some viral circRNAs, and their detection in the clinical setting already raises the spectrum of functional importance in gammaherpesvirus biology and associated malignancies. Here, we provide an overview of currently known gammaherpesvirus circular RNAs and discuss reported physical and contextual properties that may be germane to future functional studies. With the Epstein-Barr virus (EBV) circRNAome being the most extensively studied to date, our discussions will be weighted toward EBV circRNAs while also addressing circRNAs discovered in the rhesus macaque lymphocryptovirus (rLCV), the Kaposi’s sarcoma herpesvirus (KSHV), and the murid gammaherpesvirus 68 (MHV68). We hope that this will help set the stage for future investigations into the functions and relevance of this new class of viral noncoding RNAs in infection and disease.Nathan A. UngerleiderScott A. TibbettsRolf RenneErik K. FlemingtonAmerican Society for MicrobiologyarticleEBVKSHVMHV68circRNAcircular RNAgammaherpesvirusMicrobiologyQR1-502ENmBio, Vol 10, Iss 2 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	EBV KSHV MHV68 circRNA circular RNA gammaherpesvirus Microbiology QR1-502
spellingShingle	EBV KSHV MHV68 circRNA circular RNA gammaherpesvirus Microbiology QR1-502 Nathan A. Ungerleider Scott A. Tibbetts Rolf Renne Erik K. Flemington Gammaherpesvirus RNAs Come Full Circle
description	ABSTRACT After an adaptive immune response is mounted, gammaherpesviruses achieve persistence through the utilization of viral noncoding RNAs to craft a suitable host cell environment in an immunologically transparent manner. While gammaherpesvirus long noncoding RNAs (lncRNAs) and microRNAs have been recognized for some time and have been actively investigated, a recent spate of reports have now identified repertoires of the circular RNA (circRNA) class of noncoding RNAs in both the lymphocryptovirus and rhadinovirus genera of gammaherpesviruses. Despite the recent nature of these findings, the detection of circRNAs across viruses and viral gene expression programs, the conservation of some viral circRNAs, and their detection in the clinical setting already raises the spectrum of functional importance in gammaherpesvirus biology and associated malignancies. Here, we provide an overview of currently known gammaherpesvirus circular RNAs and discuss reported physical and contextual properties that may be germane to future functional studies. With the Epstein-Barr virus (EBV) circRNAome being the most extensively studied to date, our discussions will be weighted toward EBV circRNAs while also addressing circRNAs discovered in the rhesus macaque lymphocryptovirus (rLCV), the Kaposi’s sarcoma herpesvirus (KSHV), and the murid gammaherpesvirus 68 (MHV68). We hope that this will help set the stage for future investigations into the functions and relevance of this new class of viral noncoding RNAs in infection and disease.
format	article
author	Nathan A. Ungerleider Scott A. Tibbetts Rolf Renne Erik K. Flemington
author_facet	Nathan A. Ungerleider Scott A. Tibbetts Rolf Renne Erik K. Flemington
author_sort	Nathan A. Ungerleider
title	Gammaherpesvirus RNAs Come Full Circle
title_short	Gammaherpesvirus RNAs Come Full Circle
title_full	Gammaherpesvirus RNAs Come Full Circle
title_fullStr	Gammaherpesvirus RNAs Come Full Circle
title_full_unstemmed	Gammaherpesvirus RNAs Come Full Circle
title_sort	gammaherpesvirus rnas come full circle
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/b5c5555eed2e45c4a86948e4d32461b7
work_keys_str_mv	AT nathanaungerleider gammaherpesvirusrnascomefullcircle AT scottatibbetts gammaherpesvirusrnascomefullcircle AT rolfrenne gammaherpesvirusrnascomefullcircle AT erikkflemington gammaherpesvirusrnascomefullcircle
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Gammaherpesvirus RNAs Come Full Circle

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