Association between COVID-19 lockdown measures and the incidence of iatrogenic versus spontaneous very preterm births in the Netherlands: a retrospective study

Abstract Background The COVID-19 pandemic led to regional or nationwide lockdowns as part of risk mitigation measurements in many countries worldwide. Recent studies suggest an unexpected and unprecedented decrease in preterm births during the initial COVID-19 lockdowns in the first half of 2020. Th...

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Autores principales:	J. Klumper, B. M. Kazemier, J. V. Been, K. W. M. Bloemenkamp, M. A. de Boer, J. J. H. M. Erwich, W. Heidema, F. J. C. M. Klumper, S. W. A. Nij Bijvank, S. G. Oei, M. A. Oudijk, S. Schoenmakers, A. S. van Teeffelen, C. J. M. de Groot
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	COVID-19 Lockdown Preterm birth Iatrogenic Spontaneous Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/b5c7359f6ed54dfc86407e50b0badb3e
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spelling	oai:doaj.org-article:b5c7359f6ed54dfc86407e50b0badb3e2021-11-14T12:32:35ZAssociation between COVID-19 lockdown measures and the incidence of iatrogenic versus spontaneous very preterm births in the Netherlands: a retrospective study10.1186/s12884-021-04249-81471-2393https://doaj.org/article/b5c7359f6ed54dfc86407e50b0badb3e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12884-021-04249-8https://doaj.org/toc/1471-2393Abstract Background The COVID-19 pandemic led to regional or nationwide lockdowns as part of risk mitigation measurements in many countries worldwide. Recent studies suggest an unexpected and unprecedented decrease in preterm births during the initial COVID-19 lockdowns in the first half of 2020. The objective of the current study was to assess the effects of the two months of the initial national COVID-19 lockdown period on the incidence of very and extremely preterm birth in the Netherlands, stratified by either spontaneous or iatrogenic onset of delivery, in both singleton and multiple pregnancies. Methods Retrospective cohort study using data from all 10 perinatal centers in the Netherlands on very and extremely preterm births during the initial COVID-19 lockdown from March 15 to May 15, 2020. Incidences of very and extremely preterm birth were calculated using an estimate of the total number of births in the Netherlands in this period. As reference, we used data from the corresponding calendar period in 2015–2018 from the national perinatal registry (Perined). We differentiated between spontaneous versus iatrogenic onset of delivery and between singleton versus multiple pregnancies. Results The incidence of total preterm birth < 32 weeks in singleton pregnancies was 6.1‰ in the study period in 2020 versus 6.5‰ in the corresponding period in 2015–2018. The decrease in preterm births in singletons was solely due to a significant decrease in iatrogenic preterm births, both < 32 weeks (OR 0.71; 95%CI 0.53 to 0.95) and < 28 weeks (OR 0.53; 95%CI 0.29 to 0.97). For multiple pregnancies, an increase in preterm births < 28 weeks was observed (OR 2.43; 95%CI 1.35 to 4.39). Conclusion This study shows a decrease in iatrogenic preterm births during the initial COVID-19-related lockdown in the Netherlands in singletons. Future studies should focus on the mechanism of action of lockdown measures and reduction of preterm birth and the effects of perinatal outcome.J. KlumperB. M. KazemierJ. V. BeenK. W. M. BloemenkampM. A. de BoerJ. J. H. M. ErwichW. HeidemaF. J. C. M. KlumperS. W. A. Nij BijvankS. G. OeiM. A. OudijkS. SchoenmakersA. S. van TeeffelenC. J. M. de GrootBMCarticleCOVID-19LockdownPreterm birthIatrogenicSpontaneousGynecology and obstetricsRG1-991ENBMC Pregnancy and Childbirth, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 Lockdown Preterm birth Iatrogenic Spontaneous Gynecology and obstetrics RG1-991
spellingShingle	COVID-19 Lockdown Preterm birth Iatrogenic Spontaneous Gynecology and obstetrics RG1-991 J. Klumper B. M. Kazemier J. V. Been K. W. M. Bloemenkamp M. A. de Boer J. J. H. M. Erwich W. Heidema F. J. C. M. Klumper S. W. A. Nij Bijvank S. G. Oei M. A. Oudijk S. Schoenmakers A. S. van Teeffelen C. J. M. de Groot Association between COVID-19 lockdown measures and the incidence of iatrogenic versus spontaneous very preterm births in the Netherlands: a retrospective study
description	Abstract Background The COVID-19 pandemic led to regional or nationwide lockdowns as part of risk mitigation measurements in many countries worldwide. Recent studies suggest an unexpected and unprecedented decrease in preterm births during the initial COVID-19 lockdowns in the first half of 2020. The objective of the current study was to assess the effects of the two months of the initial national COVID-19 lockdown period on the incidence of very and extremely preterm birth in the Netherlands, stratified by either spontaneous or iatrogenic onset of delivery, in both singleton and multiple pregnancies. Methods Retrospective cohort study using data from all 10 perinatal centers in the Netherlands on very and extremely preterm births during the initial COVID-19 lockdown from March 15 to May 15, 2020. Incidences of very and extremely preterm birth were calculated using an estimate of the total number of births in the Netherlands in this period. As reference, we used data from the corresponding calendar period in 2015–2018 from the national perinatal registry (Perined). We differentiated between spontaneous versus iatrogenic onset of delivery and between singleton versus multiple pregnancies. Results The incidence of total preterm birth < 32 weeks in singleton pregnancies was 6.1‰ in the study period in 2020 versus 6.5‰ in the corresponding period in 2015–2018. The decrease in preterm births in singletons was solely due to a significant decrease in iatrogenic preterm births, both < 32 weeks (OR 0.71; 95%CI 0.53 to 0.95) and < 28 weeks (OR 0.53; 95%CI 0.29 to 0.97). For multiple pregnancies, an increase in preterm births < 28 weeks was observed (OR 2.43; 95%CI 1.35 to 4.39). Conclusion This study shows a decrease in iatrogenic preterm births during the initial COVID-19-related lockdown in the Netherlands in singletons. Future studies should focus on the mechanism of action of lockdown measures and reduction of preterm birth and the effects of perinatal outcome.
format	article
author	J. Klumper B. M. Kazemier J. V. Been K. W. M. Bloemenkamp M. A. de Boer J. J. H. M. Erwich W. Heidema F. J. C. M. Klumper S. W. A. Nij Bijvank S. G. Oei M. A. Oudijk S. Schoenmakers A. S. van Teeffelen C. J. M. de Groot
author_facet	J. Klumper B. M. Kazemier J. V. Been K. W. M. Bloemenkamp M. A. de Boer J. J. H. M. Erwich W. Heidema F. J. C. M. Klumper S. W. A. Nij Bijvank S. G. Oei M. A. Oudijk S. Schoenmakers A. S. van Teeffelen C. J. M. de Groot
author_sort	J. Klumper
title	Association between COVID-19 lockdown measures and the incidence of iatrogenic versus spontaneous very preterm births in the Netherlands: a retrospective study
title_short	Association between COVID-19 lockdown measures and the incidence of iatrogenic versus spontaneous very preterm births in the Netherlands: a retrospective study
title_full	Association between COVID-19 lockdown measures and the incidence of iatrogenic versus spontaneous very preterm births in the Netherlands: a retrospective study
title_fullStr	Association between COVID-19 lockdown measures and the incidence of iatrogenic versus spontaneous very preterm births in the Netherlands: a retrospective study
title_full_unstemmed	Association between COVID-19 lockdown measures and the incidence of iatrogenic versus spontaneous very preterm births in the Netherlands: a retrospective study
title_sort	association between covid-19 lockdown measures and the incidence of iatrogenic versus spontaneous very preterm births in the netherlands: a retrospective study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/b5c7359f6ed54dfc86407e50b0badb3e
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Association between COVID-19 lockdown measures and the incidence of iatrogenic versus spontaneous very preterm births in the Netherlands: a retrospective study

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