Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum

µ-opioid receptors (MOR) are known to modulate the reward effects of drugs of abuse, and MOR activation induces long-term depression (LTD) at striatal synapses. Here the authors show that alcohol exposure disrupts MOR-induced LTD only at specific cortical inputs to the striatum.

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Autores principales:	Braulio Muñoz, Brandon M. Fritz, Fuqin Yin, Brady K. Atwood
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b5c94352b7214fd5bde3778c39f3805f
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spelling	oai:doaj.org-article:b5c94352b7214fd5bde3778c39f3805f2021-12-02T16:49:16ZAlcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum10.1038/s41467-018-03683-12041-1723https://doaj.org/article/b5c94352b7214fd5bde3778c39f3805f2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03683-1https://doaj.org/toc/2041-1723µ-opioid receptors (MOR) are known to modulate the reward effects of drugs of abuse, and MOR activation induces long-term depression (LTD) at striatal synapses. Here the authors show that alcohol exposure disrupts MOR-induced LTD only at specific cortical inputs to the striatum.Braulio MuñozBrandon M. FritzFuqin YinBrady K. AtwoodNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Braulio Muñoz Brandon M. Fritz Fuqin Yin Brady K. Atwood Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum
description	µ-opioid receptors (MOR) are known to modulate the reward effects of drugs of abuse, and MOR activation induces long-term depression (LTD) at striatal synapses. Here the authors show that alcohol exposure disrupts MOR-induced LTD only at specific cortical inputs to the striatum.
format	article
author	Braulio Muñoz Brandon M. Fritz Fuqin Yin Brady K. Atwood
author_facet	Braulio Muñoz Brandon M. Fritz Fuqin Yin Brady K. Atwood
author_sort	Braulio Muñoz
title	Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum
title_short	Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum
title_full	Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum
title_fullStr	Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum
title_full_unstemmed	Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum
title_sort	alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b5c94352b7214fd5bde3778c39f3805f
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Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum

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