Mapping of the benzoate metabolism by human gut microbiome indicates food-derived metagenome evolution

Abstract Sodium benzoate is one of the widely used food preservatives and its metabolism in the human body has been studied only with the host perspective. Despite the human gut microbiome being considered as a virtual human organ, its role in benzoate metabolism is yet to be elucidated. The current...

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Autores principales:	Monika Yadav, Avinash Lomash, Seema Kapoor, Rajesh Pandey, Nar Singh Chauhan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b5ca58f989a248cca031c068218dd9f8
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spelling	oai:doaj.org-article:b5ca58f989a248cca031c068218dd9f82021-12-02T13:19:22ZMapping of the benzoate metabolism by human gut microbiome indicates food-derived metagenome evolution10.1038/s41598-021-84964-62045-2322https://doaj.org/article/b5ca58f989a248cca031c068218dd9f82021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84964-6https://doaj.org/toc/2045-2322Abstract Sodium benzoate is one of the widely used food preservatives and its metabolism in the human body has been studied only with the host perspective. Despite the human gut microbiome being considered as a virtual human organ, its role in benzoate metabolism is yet to be elucidated. The current study uses a multi-omic approach to rationalize the role of human gut microbes in benzoate metabolism. Microbial diversity analysis with multiple features synchronously indicates the dominance of Bacteroidetes followed by Firmicutes, Actinobacteria, and Proteobacteria. Metagenomic exploration highlights the presence of benzoate catabolic protein features. These features were mapped on to the aerobic and anaerobic pathways of benzoate catabolism. Benzoate catabolism assays identified statistically significant metabolites (P < 0.05) associated with the protocatechuate branch of the beta-ketoadipate pathway of the benzoate metabolism. Analysis of the 201 human gut metagenomic datasets across diverse populations indicates the omnipresence of these features. Enrichment of the benzoate catabolic protein features in human gut microbes rationalizes their role in benzoate catabolism, as well as indicates food-derived microbiome evolution.Monika YadavAvinash LomashSeema KapoorRajesh PandeyNar Singh ChauhanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Monika Yadav Avinash Lomash Seema Kapoor Rajesh Pandey Nar Singh Chauhan Mapping of the benzoate metabolism by human gut microbiome indicates food-derived metagenome evolution
description	Abstract Sodium benzoate is one of the widely used food preservatives and its metabolism in the human body has been studied only with the host perspective. Despite the human gut microbiome being considered as a virtual human organ, its role in benzoate metabolism is yet to be elucidated. The current study uses a multi-omic approach to rationalize the role of human gut microbes in benzoate metabolism. Microbial diversity analysis with multiple features synchronously indicates the dominance of Bacteroidetes followed by Firmicutes, Actinobacteria, and Proteobacteria. Metagenomic exploration highlights the presence of benzoate catabolic protein features. These features were mapped on to the aerobic and anaerobic pathways of benzoate catabolism. Benzoate catabolism assays identified statistically significant metabolites (P < 0.05) associated with the protocatechuate branch of the beta-ketoadipate pathway of the benzoate metabolism. Analysis of the 201 human gut metagenomic datasets across diverse populations indicates the omnipresence of these features. Enrichment of the benzoate catabolic protein features in human gut microbes rationalizes their role in benzoate catabolism, as well as indicates food-derived microbiome evolution.
format	article
author	Monika Yadav Avinash Lomash Seema Kapoor Rajesh Pandey Nar Singh Chauhan
author_facet	Monika Yadav Avinash Lomash Seema Kapoor Rajesh Pandey Nar Singh Chauhan
author_sort	Monika Yadav
title	Mapping of the benzoate metabolism by human gut microbiome indicates food-derived metagenome evolution
title_short	Mapping of the benzoate metabolism by human gut microbiome indicates food-derived metagenome evolution
title_full	Mapping of the benzoate metabolism by human gut microbiome indicates food-derived metagenome evolution
title_fullStr	Mapping of the benzoate metabolism by human gut microbiome indicates food-derived metagenome evolution
title_full_unstemmed	Mapping of the benzoate metabolism by human gut microbiome indicates food-derived metagenome evolution
title_sort	mapping of the benzoate metabolism by human gut microbiome indicates food-derived metagenome evolution
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b5ca58f989a248cca031c068218dd9f8
work_keys_str_mv	AT monikayadav mappingofthebenzoatemetabolismbyhumangutmicrobiomeindicatesfoodderivedmetagenomeevolution AT avinashlomash mappingofthebenzoatemetabolismbyhumangutmicrobiomeindicatesfoodderivedmetagenomeevolution AT seemakapoor mappingofthebenzoatemetabolismbyhumangutmicrobiomeindicatesfoodderivedmetagenomeevolution AT rajeshpandey mappingofthebenzoatemetabolismbyhumangutmicrobiomeindicatesfoodderivedmetagenomeevolution AT narsinghchauhan mappingofthebenzoatemetabolismbyhumangutmicrobiomeindicatesfoodderivedmetagenomeevolution
_version_	1718393292710739968

Mapping of the benzoate metabolism by human gut microbiome indicates food-derived metagenome evolution

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