Strong host-feeding preferences of the vector Triatoma infestans modified by vector density: implications for the epidemiology of Chagas disease.

<h4>Background</h4>Understanding the factors that affect the host-feeding preferences of triatomine bugs is crucial for estimating transmission risks and predicting the effects of control tactics targeting domestic animals. We tested whether Triatoma infestans bugs prefer to feed on dogs...

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Autores principales:	Ricardo E Gürtler, Leonardo A Ceballos, Paula Ordóñez-Krasnowski, Leonardo A Lanati, Raúl Stariolo, Uriel Kitron
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/b5ca5a134d344863a3548e8ce3d3a424
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spelling	oai:doaj.org-article:b5ca5a134d344863a3548e8ce3d3a4242021-11-25T06:33:20ZStrong host-feeding preferences of the vector Triatoma infestans modified by vector density: implications for the epidemiology of Chagas disease.1935-27271935-273510.1371/journal.pntd.0000447https://doaj.org/article/b5ca5a134d344863a3548e8ce3d3a4242009-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19478849/pdf/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Understanding the factors that affect the host-feeding preferences of triatomine bugs is crucial for estimating transmission risks and predicting the effects of control tactics targeting domestic animals. We tested whether Triatoma infestans bugs prefer to feed on dogs vs. chickens and on dogs vs. cats and whether vector density modified host choices and other vital rates under natural conditions.<h4>Methodology</h4>Two host choice experiments were conducted in small caged huts with two rooms between which bugs could move freely. Matched pairs of dog-chicken (six) and dog-cat (three) were assigned randomly to two levels of vector abundance and exposed to starved bugs during three nights. Bloodmeals from 1,160 bugs were tested by a direct enzyme-linked immunosorbent assay.<h4>Principal findings</h4>Conditional logistic regression showed that dogs were highly preferred over chickens or cats and that vector density modified host-feeding choices. The relative risk of a bug being blood-engorged increased significantly when it fed only on dog rather than chicken or cat. Bugs achieved higher post-exposure weight at higher vector densities and successive occasions, more so if they fed on a dog rather than on a cat.<h4>Conclusions</h4>Our findings strongly refute the hypothesis that T. infestans prefers to blood-feed on chickens rather than dogs. An increase in dog or cat availability or accessibility will increase the rate of bug feeding on them and exert strong non-linear effects on R(0). When combined with between-dog heterogeneities in exposure, infection, and infectiousness, the strong bug preference for dogs can be exploited to target dogs in general, and even the specific individuals that account for most of the risk, with topical lotions or insecticide-impregnated collars to turn them into baited lethal traps or use them as transmission or infestation sentinels based on their immune response to Trypanosoma cruzi or bug salivary antigens.Ricardo E GürtlerLeonardo A CeballosPaula Ordóñez-KrasnowskiLeonardo A LanatiRaúl StarioloUriel KitronPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 3, Iss 5, p e447 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ricardo E Gürtler Leonardo A Ceballos Paula Ordóñez-Krasnowski Leonardo A Lanati Raúl Stariolo Uriel Kitron Strong host-feeding preferences of the vector Triatoma infestans modified by vector density: implications for the epidemiology of Chagas disease.
description	<h4>Background</h4>Understanding the factors that affect the host-feeding preferences of triatomine bugs is crucial for estimating transmission risks and predicting the effects of control tactics targeting domestic animals. We tested whether Triatoma infestans bugs prefer to feed on dogs vs. chickens and on dogs vs. cats and whether vector density modified host choices and other vital rates under natural conditions.<h4>Methodology</h4>Two host choice experiments were conducted in small caged huts with two rooms between which bugs could move freely. Matched pairs of dog-chicken (six) and dog-cat (three) were assigned randomly to two levels of vector abundance and exposed to starved bugs during three nights. Bloodmeals from 1,160 bugs were tested by a direct enzyme-linked immunosorbent assay.<h4>Principal findings</h4>Conditional logistic regression showed that dogs were highly preferred over chickens or cats and that vector density modified host-feeding choices. The relative risk of a bug being blood-engorged increased significantly when it fed only on dog rather than chicken or cat. Bugs achieved higher post-exposure weight at higher vector densities and successive occasions, more so if they fed on a dog rather than on a cat.<h4>Conclusions</h4>Our findings strongly refute the hypothesis that T. infestans prefers to blood-feed on chickens rather than dogs. An increase in dog or cat availability or accessibility will increase the rate of bug feeding on them and exert strong non-linear effects on R(0). When combined with between-dog heterogeneities in exposure, infection, and infectiousness, the strong bug preference for dogs can be exploited to target dogs in general, and even the specific individuals that account for most of the risk, with topical lotions or insecticide-impregnated collars to turn them into baited lethal traps or use them as transmission or infestation sentinels based on their immune response to Trypanosoma cruzi or bug salivary antigens.
format	article
author	Ricardo E Gürtler Leonardo A Ceballos Paula Ordóñez-Krasnowski Leonardo A Lanati Raúl Stariolo Uriel Kitron
author_facet	Ricardo E Gürtler Leonardo A Ceballos Paula Ordóñez-Krasnowski Leonardo A Lanati Raúl Stariolo Uriel Kitron
author_sort	Ricardo E Gürtler
title	Strong host-feeding preferences of the vector Triatoma infestans modified by vector density: implications for the epidemiology of Chagas disease.
title_short	Strong host-feeding preferences of the vector Triatoma infestans modified by vector density: implications for the epidemiology of Chagas disease.
title_full	Strong host-feeding preferences of the vector Triatoma infestans modified by vector density: implications for the epidemiology of Chagas disease.
title_fullStr	Strong host-feeding preferences of the vector Triatoma infestans modified by vector density: implications for the epidemiology of Chagas disease.
title_full_unstemmed	Strong host-feeding preferences of the vector Triatoma infestans modified by vector density: implications for the epidemiology of Chagas disease.
title_sort	strong host-feeding preferences of the vector triatoma infestans modified by vector density: implications for the epidemiology of chagas disease.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/b5ca5a134d344863a3548e8ce3d3a424
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Strong host-feeding preferences of the vector Triatoma infestans modified by vector density: implications for the epidemiology of Chagas disease.

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