Classification of directionally specific vagus nerve activity using an upper airway obstruction model in anesthetized rodents

Abstract Electrical signals from the peripheral nervous system have the potential to provide the necessary motor, sensory or autonomic information for implementing closed-loop control of neuroprosthetic or neuromodulatory systems. However, developing methods to recover information encoded in these s...

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Autores principales:	P. Sabetian, Y. Sadat-Nejad, Paul B. Yoo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b5ca968602644ee8a9d565af2d4e7aba
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spelling	oai:doaj.org-article:b5ca968602644ee8a9d565af2d4e7aba2021-12-02T15:45:31ZClassification of directionally specific vagus nerve activity using an upper airway obstruction model in anesthetized rodents10.1038/s41598-021-89624-32045-2322https://doaj.org/article/b5ca968602644ee8a9d565af2d4e7aba2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89624-3https://doaj.org/toc/2045-2322Abstract Electrical signals from the peripheral nervous system have the potential to provide the necessary motor, sensory or autonomic information for implementing closed-loop control of neuroprosthetic or neuromodulatory systems. However, developing methods to recover information encoded in these signals is a significant challenge. Our goal was to test the feasibility of measuring physiologically generated nerve action potentials that can be classified as sensory or motor signals. A tetrapolar recording nerve cuff electrode was used to measure vagal nerve (VN) activity in a rodent model of upper airway obstruction. The effect of upper airway occlusions on VN activity related to respiration (RnP) was calculated and compared for 4 different cases: (1) intact VN, (2) VN transection only proximal to recording electrode, (3) VN transection only distal to the recording electrode, and (4) transection of VN proximal and distal to electrode. We employed a Support Vector Machine (SVM) model with Gaussian Kernel to learn a model capable of classifying efferent and afferent waveforms obtained from the tetrapolar electrode. In vivo results showed that the RnP values decreased significantly during obstruction by 91.7% ± 3.1%, and 78.2% ± 3.4% for cases of intact VN or proximal transection, respectively. In contrast, there were no significant changes for cases of VN transection at the distal end or both ends of the electrode. The SVM model yielded an 85.8% accuracy in distinguishing motor and sensory signals. The feasibility of measuring low-noise directionally-sensitive neural activity using a tetrapolar nerve cuff electrode along with the use of an SVM classifier was shown. Future experimental work in chronic implant studies is needed to support clinical translatability.P. SabetianY. Sadat-NejadPaul B. YooNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q P. Sabetian Y. Sadat-Nejad Paul B. Yoo Classification of directionally specific vagus nerve activity using an upper airway obstruction model in anesthetized rodents
description	Abstract Electrical signals from the peripheral nervous system have the potential to provide the necessary motor, sensory or autonomic information for implementing closed-loop control of neuroprosthetic or neuromodulatory systems. However, developing methods to recover information encoded in these signals is a significant challenge. Our goal was to test the feasibility of measuring physiologically generated nerve action potentials that can be classified as sensory or motor signals. A tetrapolar recording nerve cuff electrode was used to measure vagal nerve (VN) activity in a rodent model of upper airway obstruction. The effect of upper airway occlusions on VN activity related to respiration (RnP) was calculated and compared for 4 different cases: (1) intact VN, (2) VN transection only proximal to recording electrode, (3) VN transection only distal to the recording electrode, and (4) transection of VN proximal and distal to electrode. We employed a Support Vector Machine (SVM) model with Gaussian Kernel to learn a model capable of classifying efferent and afferent waveforms obtained from the tetrapolar electrode. In vivo results showed that the RnP values decreased significantly during obstruction by 91.7% ± 3.1%, and 78.2% ± 3.4% for cases of intact VN or proximal transection, respectively. In contrast, there were no significant changes for cases of VN transection at the distal end or both ends of the electrode. The SVM model yielded an 85.8% accuracy in distinguishing motor and sensory signals. The feasibility of measuring low-noise directionally-sensitive neural activity using a tetrapolar nerve cuff electrode along with the use of an SVM classifier was shown. Future experimental work in chronic implant studies is needed to support clinical translatability.
format	article
author	P. Sabetian Y. Sadat-Nejad Paul B. Yoo
author_facet	P. Sabetian Y. Sadat-Nejad Paul B. Yoo
author_sort	P. Sabetian
title	Classification of directionally specific vagus nerve activity using an upper airway obstruction model in anesthetized rodents
title_short	Classification of directionally specific vagus nerve activity using an upper airway obstruction model in anesthetized rodents
title_full	Classification of directionally specific vagus nerve activity using an upper airway obstruction model in anesthetized rodents
title_fullStr	Classification of directionally specific vagus nerve activity using an upper airway obstruction model in anesthetized rodents
title_full_unstemmed	Classification of directionally specific vagus nerve activity using an upper airway obstruction model in anesthetized rodents
title_sort	classification of directionally specific vagus nerve activity using an upper airway obstruction model in anesthetized rodents
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b5ca968602644ee8a9d565af2d4e7aba
work_keys_str_mv	AT psabetian classificationofdirectionallyspecificvagusnerveactivityusinganupperairwayobstructionmodelinanesthetizedrodents AT ysadatnejad classificationofdirectionallyspecificvagusnerveactivityusinganupperairwayobstructionmodelinanesthetizedrodents AT paulbyoo classificationofdirectionallyspecificvagusnerveactivityusinganupperairwayobstructionmodelinanesthetizedrodents
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Classification of directionally specific vagus nerve activity using an upper airway obstruction model in anesthetized rodents

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