A VigiBase descriptive study of fluoroquinolone induced disabling and potentially permanent musculoskeletal and connective tissue disorders

Abstract Recent drug safety concerns described fluoroquinolone (FQ)-induced serious musculoskeletal reactions. The objective of this study was to characterize reports with FQ-associated disabling musculoskeletal disorders, from VigiBase. The analysis included all FQ-induced musculoskeletal and conne...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Madalina Huruba, Andreea Farcas, Daniel Corneliu Leucuta, Camelia Bucsa, Mariana Sipos, Cristina Mogosan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b5cc59390f4b46f3913154ed92a19fd1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b5cc59390f4b46f3913154ed92a19fd1
record_format	dspace
spelling	oai:doaj.org-article:b5cc59390f4b46f3913154ed92a19fd12021-12-02T15:33:01ZA VigiBase descriptive study of fluoroquinolone induced disabling and potentially permanent musculoskeletal and connective tissue disorders10.1038/s41598-021-93763-y2045-2322https://doaj.org/article/b5cc59390f4b46f3913154ed92a19fd12021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93763-yhttps://doaj.org/toc/2045-2322Abstract Recent drug safety concerns described fluoroquinolone (FQ)-induced serious musculoskeletal reactions. The objective of this study was to characterize reports with FQ-associated disabling musculoskeletal disorders, from VigiBase. The analysis included all FQ-induced musculoskeletal and connective tissue disorders adverse drug reaction (ADR) reports (up to July-2019), (disabling/incapacitating, or recovered/resolved with sequelae or fatal). We described aspects like reporter, suspected FQs, ADRs, associated corticosteroid therapy. We also looked into the disproportionality data in terms of proportional reporting ratio (PRR) and information component (IC) values. A total of 5355 reports with 13,563 ADRs and 5558 FQs were reported. The majority of reports were for patients aged 18–64 (62.67%), and the female gender prevailed (61.76%). Consumers reported almost half (45.99%), with a peak in reporting rates in 2017. Top reported ADRs were arthralgia (16.34%), tendonitis (11.04%), pain in extremity (9.98%), tendon pain (7.63%), and myalgia (7.17%). Top suspected FQs were levofloxacin (50.04%), ciprofloxacin (38.41%), moxifloxacin (5.16%), ofloxacin (3.17%) and norfloxacin (1.01%). For these, FQs-ADR association was supported by the disproportionality analysis. Corticosteroids were associated with about 7% of tendon related reports. The results augment the existing data on FQs safety concerns, specifically their potential effect on the musculoskeletal system.Madalina HurubaAndreea FarcasDaniel Corneliu LeucutaCamelia BucsaMariana SiposCristina MogosanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Madalina Huruba Andreea Farcas Daniel Corneliu Leucuta Camelia Bucsa Mariana Sipos Cristina Mogosan A VigiBase descriptive study of fluoroquinolone induced disabling and potentially permanent musculoskeletal and connective tissue disorders
description	Abstract Recent drug safety concerns described fluoroquinolone (FQ)-induced serious musculoskeletal reactions. The objective of this study was to characterize reports with FQ-associated disabling musculoskeletal disorders, from VigiBase. The analysis included all FQ-induced musculoskeletal and connective tissue disorders adverse drug reaction (ADR) reports (up to July-2019), (disabling/incapacitating, or recovered/resolved with sequelae or fatal). We described aspects like reporter, suspected FQs, ADRs, associated corticosteroid therapy. We also looked into the disproportionality data in terms of proportional reporting ratio (PRR) and information component (IC) values. A total of 5355 reports with 13,563 ADRs and 5558 FQs were reported. The majority of reports were for patients aged 18–64 (62.67%), and the female gender prevailed (61.76%). Consumers reported almost half (45.99%), with a peak in reporting rates in 2017. Top reported ADRs were arthralgia (16.34%), tendonitis (11.04%), pain in extremity (9.98%), tendon pain (7.63%), and myalgia (7.17%). Top suspected FQs were levofloxacin (50.04%), ciprofloxacin (38.41%), moxifloxacin (5.16%), ofloxacin (3.17%) and norfloxacin (1.01%). For these, FQs-ADR association was supported by the disproportionality analysis. Corticosteroids were associated with about 7% of tendon related reports. The results augment the existing data on FQs safety concerns, specifically their potential effect on the musculoskeletal system.
format	article
author	Madalina Huruba Andreea Farcas Daniel Corneliu Leucuta Camelia Bucsa Mariana Sipos Cristina Mogosan
author_facet	Madalina Huruba Andreea Farcas Daniel Corneliu Leucuta Camelia Bucsa Mariana Sipos Cristina Mogosan
author_sort	Madalina Huruba
title	A VigiBase descriptive study of fluoroquinolone induced disabling and potentially permanent musculoskeletal and connective tissue disorders
title_short	A VigiBase descriptive study of fluoroquinolone induced disabling and potentially permanent musculoskeletal and connective tissue disorders
title_full	A VigiBase descriptive study of fluoroquinolone induced disabling and potentially permanent musculoskeletal and connective tissue disorders
title_fullStr	A VigiBase descriptive study of fluoroquinolone induced disabling and potentially permanent musculoskeletal and connective tissue disorders
title_full_unstemmed	A VigiBase descriptive study of fluoroquinolone induced disabling and potentially permanent musculoskeletal and connective tissue disorders
title_sort	vigibase descriptive study of fluoroquinolone induced disabling and potentially permanent musculoskeletal and connective tissue disorders
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b5cc59390f4b46f3913154ed92a19fd1
work_keys_str_mv	AT madalinahuruba avigibasedescriptivestudyoffluoroquinoloneinduceddisablingandpotentiallypermanentmusculoskeletalandconnectivetissuedisorders AT andreeafarcas avigibasedescriptivestudyoffluoroquinoloneinduceddisablingandpotentiallypermanentmusculoskeletalandconnectivetissuedisorders AT danielcorneliuleucuta avigibasedescriptivestudyoffluoroquinoloneinduceddisablingandpotentiallypermanentmusculoskeletalandconnectivetissuedisorders AT cameliabucsa avigibasedescriptivestudyoffluoroquinoloneinduceddisablingandpotentiallypermanentmusculoskeletalandconnectivetissuedisorders AT marianasipos avigibasedescriptivestudyoffluoroquinoloneinduceddisablingandpotentiallypermanentmusculoskeletalandconnectivetissuedisorders AT cristinamogosan avigibasedescriptivestudyoffluoroquinoloneinduceddisablingandpotentiallypermanentmusculoskeletalandconnectivetissuedisorders AT madalinahuruba vigibasedescriptivestudyoffluoroquinoloneinduceddisablingandpotentiallypermanentmusculoskeletalandconnectivetissuedisorders AT andreeafarcas vigibasedescriptivestudyoffluoroquinoloneinduceddisablingandpotentiallypermanentmusculoskeletalandconnectivetissuedisorders AT danielcorneliuleucuta vigibasedescriptivestudyoffluoroquinoloneinduceddisablingandpotentiallypermanentmusculoskeletalandconnectivetissuedisorders AT cameliabucsa vigibasedescriptivestudyoffluoroquinoloneinduceddisablingandpotentiallypermanentmusculoskeletalandconnectivetissuedisorders AT marianasipos vigibasedescriptivestudyoffluoroquinoloneinduceddisablingandpotentiallypermanentmusculoskeletalandconnectivetissuedisorders AT cristinamogosan vigibasedescriptivestudyoffluoroquinoloneinduceddisablingandpotentiallypermanentmusculoskeletalandconnectivetissuedisorders
_version_	1718387163785068544

A VigiBase descriptive study of fluoroquinolone induced disabling and potentially permanent musculoskeletal and connective tissue disorders

Ejemplares similares