The Prognostic and Predictive Role of Chromogranin A in Gastroenteropancreatic Neuroendocrine Tumors – A Single-Center Experience
Chromogranin A (CgA) is a non-specific biomarker excreted by neuroendocrine tumor (NET) cells. Elevation of circulating CgA level can be detected in gastroenteropancreatic (GEP)-NET patients and has been shown to correlate with tumor burden. The prognostic and predictive roles of CgA level and the c...
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2021
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oai:doaj.org-article:b5cd3260d8974337a47bcaa9143429fd2021-11-12T05:02:22ZThe Prognostic and Predictive Role of Chromogranin A in Gastroenteropancreatic Neuroendocrine Tumors – A Single-Center Experience2234-943X10.3389/fonc.2021.741096https://doaj.org/article/b5cd3260d8974337a47bcaa9143429fd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.741096/fullhttps://doaj.org/toc/2234-943XChromogranin A (CgA) is a non-specific biomarker excreted by neuroendocrine tumor (NET) cells. Elevation of circulating CgA level can be detected in gastroenteropancreatic (GEP)-NET patients and has been shown to correlate with tumor burden. The prognostic and predictive roles of CgA level and the change of CgA level are controversial. In this study, we retrospectively analyzed 102 grade 1/2 GEP-NET patients with available baseline or serial follow-up CgA levels from the National Cheng Kung University Hospital to evaluate the association between circulating CgA level and the tumor extent, overall survival (OS), and tumor response prediction. The baseline characteristics, baseline CgA level, and change of CgA level during follow-up and their association was analyzed. Sixty cases had baseline CgA levels available prior to any treatment and ninety-four cases had serial follow-up CgA levels available during treatment or surveillance. Baseline CgA levels were associated with stage and sex. Higher baseline CgA levels were associated with worse OS after adjusting for sex, stage, grade, primary site, and functionality (hazard ratio=13.52, 95% confidence interval (CI), 1.06-172.47, P=0.045). The cross-sectional analysis for the change of CgA level during follow-up showed that a ≥ 40% increase of CgA meant a higher probability of developing tumor progression or recurrence than those with a < 40% increase of CgA level (odds ratio=5.04, 95% CI, 1.31-19.4, P=0.019) after adjusting for sex, age, grade, stage, and functionality. Our study results suggest that CgA may be a predictive marker for tumor burden, OS, and tumor progression in GEP-NET patients.Hui-Jen TsaiHui-Jen TsaiHui-Jen TsaiChin-Fu HsiaoJeffrey S. ChangLi-Tzong ChenLi-Tzong ChenLi-Tzong ChenYing-Jui ChaoChia-Ju YenYan-Shen ShanYan-Shen ShanFrontiers Media S.A.articlechromogranin Aneuroendocrine tumorsgastroenteropancreasprognostic factorpredictive factorNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021) |
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| collection |
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| topic |
chromogranin A neuroendocrine tumors gastroenteropancreas prognostic factor predictive factor Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
chromogranin A neuroendocrine tumors gastroenteropancreas prognostic factor predictive factor Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hui-Jen Tsai Hui-Jen Tsai Hui-Jen Tsai Chin-Fu Hsiao Jeffrey S. Chang Li-Tzong Chen Li-Tzong Chen Li-Tzong Chen Ying-Jui Chao Chia-Ju Yen Yan-Shen Shan Yan-Shen Shan The Prognostic and Predictive Role of Chromogranin A in Gastroenteropancreatic Neuroendocrine Tumors – A Single-Center Experience |
| description |
Chromogranin A (CgA) is a non-specific biomarker excreted by neuroendocrine tumor (NET) cells. Elevation of circulating CgA level can be detected in gastroenteropancreatic (GEP)-NET patients and has been shown to correlate with tumor burden. The prognostic and predictive roles of CgA level and the change of CgA level are controversial. In this study, we retrospectively analyzed 102 grade 1/2 GEP-NET patients with available baseline or serial follow-up CgA levels from the National Cheng Kung University Hospital to evaluate the association between circulating CgA level and the tumor extent, overall survival (OS), and tumor response prediction. The baseline characteristics, baseline CgA level, and change of CgA level during follow-up and their association was analyzed. Sixty cases had baseline CgA levels available prior to any treatment and ninety-four cases had serial follow-up CgA levels available during treatment or surveillance. Baseline CgA levels were associated with stage and sex. Higher baseline CgA levels were associated with worse OS after adjusting for sex, stage, grade, primary site, and functionality (hazard ratio=13.52, 95% confidence interval (CI), 1.06-172.47, P=0.045). The cross-sectional analysis for the change of CgA level during follow-up showed that a ≥ 40% increase of CgA meant a higher probability of developing tumor progression or recurrence than those with a < 40% increase of CgA level (odds ratio=5.04, 95% CI, 1.31-19.4, P=0.019) after adjusting for sex, age, grade, stage, and functionality. Our study results suggest that CgA may be a predictive marker for tumor burden, OS, and tumor progression in GEP-NET patients. |
| format |
article |
| author |
Hui-Jen Tsai Hui-Jen Tsai Hui-Jen Tsai Chin-Fu Hsiao Jeffrey S. Chang Li-Tzong Chen Li-Tzong Chen Li-Tzong Chen Ying-Jui Chao Chia-Ju Yen Yan-Shen Shan Yan-Shen Shan |
| author_facet |
Hui-Jen Tsai Hui-Jen Tsai Hui-Jen Tsai Chin-Fu Hsiao Jeffrey S. Chang Li-Tzong Chen Li-Tzong Chen Li-Tzong Chen Ying-Jui Chao Chia-Ju Yen Yan-Shen Shan Yan-Shen Shan |
| author_sort |
Hui-Jen Tsai |
| title |
The Prognostic and Predictive Role of Chromogranin A in Gastroenteropancreatic Neuroendocrine Tumors – A Single-Center Experience |
| title_short |
The Prognostic and Predictive Role of Chromogranin A in Gastroenteropancreatic Neuroendocrine Tumors – A Single-Center Experience |
| title_full |
The Prognostic and Predictive Role of Chromogranin A in Gastroenteropancreatic Neuroendocrine Tumors – A Single-Center Experience |
| title_fullStr |
The Prognostic and Predictive Role of Chromogranin A in Gastroenteropancreatic Neuroendocrine Tumors – A Single-Center Experience |
| title_full_unstemmed |
The Prognostic and Predictive Role of Chromogranin A in Gastroenteropancreatic Neuroendocrine Tumors – A Single-Center Experience |
| title_sort |
prognostic and predictive role of chromogranin a in gastroenteropancreatic neuroendocrine tumors – a single-center experience |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/b5cd3260d8974337a47bcaa9143429fd |
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