Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway

Williams syndrome transcription factor (WSTF) participates in diverse cellular processes, including tumor cell proliferation and migration. However, the function of WSTF in glioblastoma (GBM) remains unknown. Data from the Gene Expression Profiling Interactive Analysis (GEPIA) and The Cancer Genome...

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Autores principales:	Liyuan Yang, Chunfu Du, Hui Chen, Zhengwen Diao
Formato:	article
Lenguaje:	EN
Publicado:	PAGEPress Publications 2021
Materias:	WSTF glioblastoma proliferation invasion PI3K/AKT Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b5d1a43982ec4955b501890851ba6724
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spelling	oai:doaj.org-article:b5d1a43982ec4955b501890851ba67242021-11-17T07:41:24ZDownregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway10.4081/ejh.2021.32551121-760X2038-8306https://doaj.org/article/b5d1a43982ec4955b501890851ba67242021-11-01T00:00:00Zhttps://ejh.it/index.php/ejh/article/view/3255https://doaj.org/toc/1121-760Xhttps://doaj.org/toc/2038-8306 Williams syndrome transcription factor (WSTF) participates in diverse cellular processes, including tumor cell proliferation and migration. However, the function of WSTF in glioblastoma (GBM) remains unknown. Data from the Gene Expression Profiling Interactive Analysis (GEPIA) and The Cancer Genome Atlas (TCGA) datasets showed that WSTF was up-regulated in GBM tissues. Moreover, WSTF was also increased in the GBM cells. pcDNA-mediated over-expression of WSTF contributed to cell proliferation and invasion of GBM cells, while GBM cell proliferation and invasion were suppressed by shRNA-mediated silencing of WSTF. Additionally, GBM cell apoptosis was reduced by over-expression of WSTF accompanied by decrease in Bax and cleaved caspase-3, while promoted by silencing of WSTF with increase in Bax and cleaved caspase-3. Protein expression of AKT phosphorylation was enhanced by WSTF over-expression while reduced by WSTF silencing. Inhibitor of phosphatidylinositol 3 kinase attenuated WSTF over-expression-induced increase in GBM cell proliferation and invasion. In conclusion, WSTF contributed to GBM cell growth and invasion through activation of PI3K/AKT pathway. Liyuan YangChunfu DuHui ChenZhengwen DiaoPAGEPress PublicationsarticleWSTFglioblastomaproliferationinvasionPI3K/AKTBiology (General)QH301-705.5ENEuropean Journal of Histochemistry , Vol 65, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	WSTF glioblastoma proliferation invasion PI3K/AKT Biology (General) QH301-705.5
spellingShingle	WSTF glioblastoma proliferation invasion PI3K/AKT Biology (General) QH301-705.5 Liyuan Yang Chunfu Du Hui Chen Zhengwen Diao Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway
description	Williams syndrome transcription factor (WSTF) participates in diverse cellular processes, including tumor cell proliferation and migration. However, the function of WSTF in glioblastoma (GBM) remains unknown. Data from the Gene Expression Profiling Interactive Analysis (GEPIA) and The Cancer Genome Atlas (TCGA) datasets showed that WSTF was up-regulated in GBM tissues. Moreover, WSTF was also increased in the GBM cells. pcDNA-mediated over-expression of WSTF contributed to cell proliferation and invasion of GBM cells, while GBM cell proliferation and invasion were suppressed by shRNA-mediated silencing of WSTF. Additionally, GBM cell apoptosis was reduced by over-expression of WSTF accompanied by decrease in Bax and cleaved caspase-3, while promoted by silencing of WSTF with increase in Bax and cleaved caspase-3. Protein expression of AKT phosphorylation was enhanced by WSTF over-expression while reduced by WSTF silencing. Inhibitor of phosphatidylinositol 3 kinase attenuated WSTF over-expression-induced increase in GBM cell proliferation and invasion. In conclusion, WSTF contributed to GBM cell growth and invasion through activation of PI3K/AKT pathway.
format	article
author	Liyuan Yang Chunfu Du Hui Chen Zhengwen Diao
author_facet	Liyuan Yang Chunfu Du Hui Chen Zhengwen Diao
author_sort	Liyuan Yang
title	Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway
title_short	Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway
title_full	Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway
title_fullStr	Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway
title_full_unstemmed	Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway
title_sort	downregulation of williams syndrome transcription factor (wstf) suppresses glioblastoma cell growth and invasion by inhibiting pi3k/akt signal pathway
publisher	PAGEPress Publications
publishDate	2021
url	https://doaj.org/article/b5d1a43982ec4955b501890851ba6724
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Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway

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