PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model
Blocking the PD-1 pathway was shown to be effective in amyloid beta mouse models, yet little is known about its therapeutic potential in models of tauopathy. The authors show here that blocking PD-L1, a PD-1 ligand, is similarly effective, and that both treatments reversed cognitive deficiencies, an...
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Nature Portfolio
2019
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oai:doaj.org-article:b5d1dae5c110405690c42c4d4f5633f92021-12-02T17:01:47ZPD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model10.1038/s41467-019-08352-52041-1723https://doaj.org/article/b5d1dae5c110405690c42c4d4f5633f92019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08352-5https://doaj.org/toc/2041-1723Blocking the PD-1 pathway was shown to be effective in amyloid beta mouse models, yet little is known about its therapeutic potential in models of tauopathy. The authors show here that blocking PD-L1, a PD-1 ligand, is similarly effective, and that both treatments reversed cognitive deficiencies, and modified disease pathology not only in an animal model of AD, but also in the DM-hTAU mouse tauopathy model, through a mechanism that involves monocyte-derived macrophages.Neta RosenzweigRaz Dvir-SzternfeldAfroditi Tsitsou-KampeliHadas Keren-ShaulHila Ben-YehudaPierre Weill-RaynalLiora CahalonAlex KertserKuti BaruchIdo AmitAssaf WeinerMichal SchwartzNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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EN |
| topic |
Science Q |
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Science Q Neta Rosenzweig Raz Dvir-Szternfeld Afroditi Tsitsou-Kampeli Hadas Keren-Shaul Hila Ben-Yehuda Pierre Weill-Raynal Liora Cahalon Alex Kertser Kuti Baruch Ido Amit Assaf Weiner Michal Schwartz PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model |
| description |
Blocking the PD-1 pathway was shown to be effective in amyloid beta mouse models, yet little is known about its therapeutic potential in models of tauopathy. The authors show here that blocking PD-L1, a PD-1 ligand, is similarly effective, and that both treatments reversed cognitive deficiencies, and modified disease pathology not only in an animal model of AD, but also in the DM-hTAU mouse tauopathy model, through a mechanism that involves monocyte-derived macrophages. |
| format |
article |
| author |
Neta Rosenzweig Raz Dvir-Szternfeld Afroditi Tsitsou-Kampeli Hadas Keren-Shaul Hila Ben-Yehuda Pierre Weill-Raynal Liora Cahalon Alex Kertser Kuti Baruch Ido Amit Assaf Weiner Michal Schwartz |
| author_facet |
Neta Rosenzweig Raz Dvir-Szternfeld Afroditi Tsitsou-Kampeli Hadas Keren-Shaul Hila Ben-Yehuda Pierre Weill-Raynal Liora Cahalon Alex Kertser Kuti Baruch Ido Amit Assaf Weiner Michal Schwartz |
| author_sort |
Neta Rosenzweig |
| title |
PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model |
| title_short |
PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model |
| title_full |
PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model |
| title_fullStr |
PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model |
| title_full_unstemmed |
PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model |
| title_sort |
pd-1/pd-l1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/b5d1dae5c110405690c42c4d4f5633f9 |
| work_keys_str_mv |
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| _version_ |
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