Drosophila wing imaginal discs respond to mechanical injury via slow InsP3R-mediated intercellular calcium waves

It is unclear what role calcium signalling plays in the Drosophila wing disc. Here, the authors show that on mechanical stress, slow, long-range intercellular calcium waves are initiated in vivo and ex vivo, mediated by the inositol-3-phosphate receptor, the calcium pump SERCA and gap junction compo...

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Autores principales: Simon Restrepo, Konrad Basler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/b5d379d1c5404867bd70a347782c2a54
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Sumario:It is unclear what role calcium signalling plays in the Drosophila wing disc. Here, the authors show that on mechanical stress, slow, long-range intercellular calcium waves are initiated in vivo and ex vivo, mediated by the inositol-3-phosphate receptor, the calcium pump SERCA and gap junction component Inx2.