Renal Changes in Cocaine Abuse and Addiction

Cocaine is a natural alkaloid extracted from the leaves of the South American plant Erythroxylum coca or synthesized chemically. After cannabis, it is the second most frequently abused recreational substance worldwide. Cocaine can affect every tissue and organ within the human body, including the ki...

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Autores principales:	Nikolova M., Milenova Vl., Yosifov D., Vlahov Y., Tenev V.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2019
Materias:	cocaine systemic effects renal damage rhabdomyolysis ischemia hypertension coagulation cholesterol Medicine R
Acceso en línea:	https://doaj.org/article/b5d53067f3e948c296eb102d18f75d35
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spelling	oai:doaj.org-article:b5d53067f3e948c296eb102d18f75d352021-12-02T17:31:32ZRenal Changes in Cocaine Abuse and Addiction0324-175010.2478/amb-2019-0020https://doaj.org/article/b5d53067f3e948c296eb102d18f75d352019-05-01T00:00:00Zhttps://doi.org/10.2478/amb-2019-0020https://doaj.org/toc/0324-1750Cocaine is a natural alkaloid extracted from the leaves of the South American plant Erythroxylum coca or synthesized chemically. After cannabis, it is the second most frequently abused recreational substance worldwide. Cocaine can affect every tissue and organ within the human body, including the kidneys, causing tissue ischemia due to vasoconstriction, endothelial dysfunction and damage, procoagulant activity and oxidative stress with subsequent ischemic infarctions and fibrosis. The renal changes in cocaine abuse and addiction are due to rhabdomyolysis, ischemic, hypertensive, and inflammatory changes with the development of cell proliferation and fibrosis. The authors present three patients with cocaine-associated renal damage and discuss the underlying mechanisms of cocaine-induces tissue changes.Nikolova M.Milenova Vl.Yosifov D.Vlahov Y.Tenev V.Sciendoarticlecocainesystemic effectsrenal damagerhabdomyolysisischemiahypertensioncoagulationcholesterolMedicineRENActa Medica Bulgarica, Vol 46, Iss 2, Pp 57-61 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	cocaine systemic effects renal damage rhabdomyolysis ischemia hypertension coagulation cholesterol Medicine R
spellingShingle	cocaine systemic effects renal damage rhabdomyolysis ischemia hypertension coagulation cholesterol Medicine R Nikolova M. Milenova Vl. Yosifov D. Vlahov Y. Tenev V. Renal Changes in Cocaine Abuse and Addiction
description	Cocaine is a natural alkaloid extracted from the leaves of the South American plant Erythroxylum coca or synthesized chemically. After cannabis, it is the second most frequently abused recreational substance worldwide. Cocaine can affect every tissue and organ within the human body, including the kidneys, causing tissue ischemia due to vasoconstriction, endothelial dysfunction and damage, procoagulant activity and oxidative stress with subsequent ischemic infarctions and fibrosis. The renal changes in cocaine abuse and addiction are due to rhabdomyolysis, ischemic, hypertensive, and inflammatory changes with the development of cell proliferation and fibrosis. The authors present three patients with cocaine-associated renal damage and discuss the underlying mechanisms of cocaine-induces tissue changes.
format	article
author	Nikolova M. Milenova Vl. Yosifov D. Vlahov Y. Tenev V.
author_facet	Nikolova M. Milenova Vl. Yosifov D. Vlahov Y. Tenev V.
author_sort	Nikolova M.
title	Renal Changes in Cocaine Abuse and Addiction
title_short	Renal Changes in Cocaine Abuse and Addiction
title_full	Renal Changes in Cocaine Abuse and Addiction
title_fullStr	Renal Changes in Cocaine Abuse and Addiction
title_full_unstemmed	Renal Changes in Cocaine Abuse and Addiction
title_sort	renal changes in cocaine abuse and addiction
publisher	Sciendo
publishDate	2019
url	https://doaj.org/article/b5d53067f3e948c296eb102d18f75d35
work_keys_str_mv	AT nikolovam renalchangesincocaineabuseandaddiction AT milenovavl renalchangesincocaineabuseandaddiction AT yosifovd renalchangesincocaineabuseandaddiction AT vlahovy renalchangesincocaineabuseandaddiction AT tenevv renalchangesincocaineabuseandaddiction
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Renal Changes in Cocaine Abuse and Addiction

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