Lower serum brain-derived neurotrophic factor levels are associated with failure to achieve remission in patients with major depression after escitalopram treatment

Bun-Hee Lee,1 Young-Min Park,2 Tae Hyun Um,3 Sollip Kim3 1Department of Psychiatry, Gangnam Eulji Hospital, Eulji University, Seoul, 2Department of Psychiatry, 3Department of Laboratory Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, South Korea Background: Remission,...

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Autores principales:	Lee BH, Park YM, Um TH, Kim S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b5d55e3d91e948ada3e09aa3e30367cf
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spelling	oai:doaj.org-article:b5d55e3d91e948ada3e09aa3e30367cf2021-12-02T00:18:33ZLower serum brain-derived neurotrophic factor levels are associated with failure to achieve remission in patients with major depression after escitalopram treatment1178-2021https://doaj.org/article/b5d55e3d91e948ada3e09aa3e30367cf2014-07-01T00:00:00Zhttp://www.dovepress.com/lower-serum-brain-derived-neurotrophic-factor-levels-are-associated-wi-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Bun-Hee Lee,1 Young-Min Park,2 Tae Hyun Um,3 Sollip Kim3 1Department of Psychiatry, Gangnam Eulji Hospital, Eulji University, Seoul, 2Department of Psychiatry, 3Department of Laboratory Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, South Korea Background: Remission, the primary goal of treatment for major depressive disorder (MDD), is the absence of significant signs or symptoms and the return to a state of normal functioning. A recent study found that the level of brain-derived neurotrophic factor (BDNF) increased after antidepressant treatment in remitted patients. This study evaluated serum BDNF levels in MDD patients with chronic maintenance treatment, and compared these between remission and nonremission groups.Materials and methods: Serum BDNF levels were measured in 34 MDD patients and 35 healthy controls. The severity of depression was measured using the Hamilton Depression Rating Scale (Ham-D). The MDD patients were divided into remission and nonremission groups according to a cutoff total Ham-D score of either ≤7 or ≤6.Results: Serum BDNF levels differed significantly between the remission, nonremission, and healthy control groups (P<0.05). The Bonferroni post hoc test confirmed that serum BDNF levels were significantly lower in the nonremission group than in the healthy-control group (P<0.05), but did not differ significantly between the remission and healthy-control groups.Limitations: This study included a small sample, and measured serum BDNF levels in the MDD patients at only one point during the maintenance treatment.Conclusion: This study found that serum BDNF levels during maintenance treatment were lower in MDD patients with failure to achieve remission than in controls, while the remitted subjects had normalized serum BDNF levels. A lower level of serum BDNF during maintenance treatment is associated with failure to achieve remission in patients with major depression. Moreover, serum BDNF levels after chronic antidepressant treatment can be used as a biological marker for detecting nonremission. Keywords: brain-derived neurotrophic factor, major depression, remissionLee BHPark YMUm THKim SDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 1393-1398 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Lee BH Park YM Um TH Kim S Lower serum brain-derived neurotrophic factor levels are associated with failure to achieve remission in patients with major depression after escitalopram treatment
description	Bun-Hee Lee,1 Young-Min Park,2 Tae Hyun Um,3 Sollip Kim3 1Department of Psychiatry, Gangnam Eulji Hospital, Eulji University, Seoul, 2Department of Psychiatry, 3Department of Laboratory Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, South Korea Background: Remission, the primary goal of treatment for major depressive disorder (MDD), is the absence of significant signs or symptoms and the return to a state of normal functioning. A recent study found that the level of brain-derived neurotrophic factor (BDNF) increased after antidepressant treatment in remitted patients. This study evaluated serum BDNF levels in MDD patients with chronic maintenance treatment, and compared these between remission and nonremission groups.Materials and methods: Serum BDNF levels were measured in 34 MDD patients and 35 healthy controls. The severity of depression was measured using the Hamilton Depression Rating Scale (Ham-D). The MDD patients were divided into remission and nonremission groups according to a cutoff total Ham-D score of either ≤7 or ≤6.Results: Serum BDNF levels differed significantly between the remission, nonremission, and healthy control groups (P<0.05). The Bonferroni post hoc test confirmed that serum BDNF levels were significantly lower in the nonremission group than in the healthy-control group (P<0.05), but did not differ significantly between the remission and healthy-control groups.Limitations: This study included a small sample, and measured serum BDNF levels in the MDD patients at only one point during the maintenance treatment.Conclusion: This study found that serum BDNF levels during maintenance treatment were lower in MDD patients with failure to achieve remission than in controls, while the remitted subjects had normalized serum BDNF levels. A lower level of serum BDNF during maintenance treatment is associated with failure to achieve remission in patients with major depression. Moreover, serum BDNF levels after chronic antidepressant treatment can be used as a biological marker for detecting nonremission. Keywords: brain-derived neurotrophic factor, major depression, remission
format	article
author	Lee BH Park YM Um TH Kim S
author_facet	Lee BH Park YM Um TH Kim S
author_sort	Lee BH
title	Lower serum brain-derived neurotrophic factor levels are associated with failure to achieve remission in patients with major depression after escitalopram treatment
title_short	Lower serum brain-derived neurotrophic factor levels are associated with failure to achieve remission in patients with major depression after escitalopram treatment
title_full	Lower serum brain-derived neurotrophic factor levels are associated with failure to achieve remission in patients with major depression after escitalopram treatment
title_fullStr	Lower serum brain-derived neurotrophic factor levels are associated with failure to achieve remission in patients with major depression after escitalopram treatment
title_full_unstemmed	Lower serum brain-derived neurotrophic factor levels are associated with failure to achieve remission in patients with major depression after escitalopram treatment
title_sort	lower serum brain-derived neurotrophic factor levels are associated with failure to achieve remission in patients with major depression after escitalopram treatment
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/b5d55e3d91e948ada3e09aa3e30367cf
work_keys_str_mv	AT leebh lowerserumbrainderivedneurotrophicfactorlevelsareassociatedwithfailuretoachieveremissioninpatientswithmajordepressionafterescitalopramtreatment AT parkym lowerserumbrainderivedneurotrophicfactorlevelsareassociatedwithfailuretoachieveremissioninpatientswithmajordepressionafterescitalopramtreatment AT umth lowerserumbrainderivedneurotrophicfactorlevelsareassociatedwithfailuretoachieveremissioninpatientswithmajordepressionafterescitalopramtreatment AT kims lowerserumbrainderivedneurotrophicfactorlevelsareassociatedwithfailuretoachieveremissioninpatientswithmajordepressionafterescitalopramtreatment
_version_	1718403825547608064

Lower serum brain-derived neurotrophic factor levels are associated with failure to achieve remission in patients with major depression after escitalopram treatment

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