H-Wave<sup>®</sup> Device Stimulation: A Critical Review

Pain treatments have historically centered on drugs, but an “opioid crisis” has necessitated new standards of care, with a paradigm shift towards multi-modal pain management emphasizing early movement, non-narcotics, and various adjunctive therapies. Electrotherapies remain understudied and most lac...

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Autores principales:	Tyler K. Williamson, Hugo C. Rodriguez, Andrew Gonzaba, Neil Poddar, Stephen M. Norwood, Ashim Gupta
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pain analgesia neurogenic electrotherapy neuromuscular stimulation H-Wave Medicine R
Acceso en línea:	https://doaj.org/article/b5d629c6fa6f40eb8a275c2e56329699
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spelling	oai:doaj.org-article:b5d629c6fa6f40eb8a275c2e563296992021-11-25T18:07:27ZH-Wave<sup>®</sup> Device Stimulation: A Critical Review10.3390/jpm111111342075-4426https://doaj.org/article/b5d629c6fa6f40eb8a275c2e563296992021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1134https://doaj.org/toc/2075-4426Pain treatments have historically centered on drugs, but an “opioid crisis” has necessitated new standards of care, with a paradigm shift towards multi-modal pain management emphasizing early movement, non-narcotics, and various adjunctive therapies. Electrotherapies remain understudied and most lack high-quality clinical trials, despite a desperate need for effective adjunctive options. A systematic search of human clinical studies on H-Wave<sup>®</sup> device stimulation (HWDS) was conducted as well as a comprehensive review of articles articulating possible HWDS mechanisms of action. Studies unrelated to H-Wave were excluded. Data synthesis summarizes outcomes and study designs, categorized as pre-clinical or clinical. Pre-clinical studies demonstrated that HWDS utilizes a biphasic waveform to induce non-fatiguing muscle contractions which positively affect nerve function, blood and lymph flow. Multiple clinical studies have reported significant benefits for diabetic and non-specific neuropathic pain, where function also improved, and pain medication usage substantially dropped. In conclusion, low- to moderate-quality HWDS studies have reported reduced pain, restored functionality, and lower medication use in a variety of disorders, although higher-quality research is needed to verify condition-specific applicability. HWDS has enough reasonable evidence to be considered as an adjunctive component of non-opioid multi-modal pain management, given its excellent safety profile and relative low cost. Level of Evidence: III.Tyler K. WilliamsonHugo C. RodriguezAndrew GonzabaNeil PoddarStephen M. NorwoodAshim GuptaMDPI AGarticlepainanalgesianeurogenicelectrotherapyneuromuscular stimulationH-WaveMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1134, p 1134 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pain analgesia neurogenic electrotherapy neuromuscular stimulation H-Wave Medicine R
spellingShingle	pain analgesia neurogenic electrotherapy neuromuscular stimulation H-Wave Medicine R Tyler K. Williamson Hugo C. Rodriguez Andrew Gonzaba Neil Poddar Stephen M. Norwood Ashim Gupta H-Wave<sup>®</sup> Device Stimulation: A Critical Review
description	Pain treatments have historically centered on drugs, but an “opioid crisis” has necessitated new standards of care, with a paradigm shift towards multi-modal pain management emphasizing early movement, non-narcotics, and various adjunctive therapies. Electrotherapies remain understudied and most lack high-quality clinical trials, despite a desperate need for effective adjunctive options. A systematic search of human clinical studies on H-Wave<sup>®</sup> device stimulation (HWDS) was conducted as well as a comprehensive review of articles articulating possible HWDS mechanisms of action. Studies unrelated to H-Wave were excluded. Data synthesis summarizes outcomes and study designs, categorized as pre-clinical or clinical. Pre-clinical studies demonstrated that HWDS utilizes a biphasic waveform to induce non-fatiguing muscle contractions which positively affect nerve function, blood and lymph flow. Multiple clinical studies have reported significant benefits for diabetic and non-specific neuropathic pain, where function also improved, and pain medication usage substantially dropped. In conclusion, low- to moderate-quality HWDS studies have reported reduced pain, restored functionality, and lower medication use in a variety of disorders, although higher-quality research is needed to verify condition-specific applicability. HWDS has enough reasonable evidence to be considered as an adjunctive component of non-opioid multi-modal pain management, given its excellent safety profile and relative low cost. Level of Evidence: III.
format	article
author	Tyler K. Williamson Hugo C. Rodriguez Andrew Gonzaba Neil Poddar Stephen M. Norwood Ashim Gupta
author_facet	Tyler K. Williamson Hugo C. Rodriguez Andrew Gonzaba Neil Poddar Stephen M. Norwood Ashim Gupta
author_sort	Tyler K. Williamson
title	H-Wave<sup>®</sup> Device Stimulation: A Critical Review
title_short	H-Wave<sup>®</sup> Device Stimulation: A Critical Review
title_full	H-Wave<sup>®</sup> Device Stimulation: A Critical Review
title_fullStr	H-Wave<sup>®</sup> Device Stimulation: A Critical Review
title_full_unstemmed	H-Wave<sup>®</sup> Device Stimulation: A Critical Review
title_sort	h-wave<sup>®</sup> device stimulation: a critical review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b5d629c6fa6f40eb8a275c2e56329699
work_keys_str_mv	AT tylerkwilliamson hwavesupsupdevicestimulationacriticalreview AT hugocrodriguez hwavesupsupdevicestimulationacriticalreview AT andrewgonzaba hwavesupsupdevicestimulationacriticalreview AT neilpoddar hwavesupsupdevicestimulationacriticalreview AT stephenmnorwood hwavesupsupdevicestimulationacriticalreview AT ashimgupta hwavesupsupdevicestimulationacriticalreview
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H-Wave<sup>®</sup> Device Stimulation: A Critical Review

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