Meta-analysis on the relationship between HLA-DRBl gene polymorphism and cervical cancer in Chinese population.

<h4>Aim</h4>To determine the association between HLA-DRB1 haplotypes and risk of cervical cancer in unselected and samples from Chinese ethnicities.<h4>Methods</h4>A comprehensive search for articles from their inception to April 1st, 2013 was conducted from PubMed, Medline,...

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Autores principales:	Lin-Zhen Wei, Hai-Lin Wang, Xin Liu, Ya-Peng Lu, Fei Xu, Jin-Qiu Yuan, Ya-Qin Ling
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b5d76bda33fb4c65b934203587e28c81
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spelling	oai:doaj.org-article:b5d76bda33fb4c65b934203587e28c812021-11-18T08:32:29ZMeta-analysis on the relationship between HLA-DRBl gene polymorphism and cervical cancer in Chinese population.1932-620310.1371/journal.pone.0088439https://doaj.org/article/b5d76bda33fb4c65b934203587e28c812014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24551099/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Aim</h4>To determine the association between HLA-DRB1 haplotypes and risk of cervical cancer in unselected and samples from Chinese ethnicities.<h4>Methods</h4>A comprehensive search for articles from their inception to April 1st, 2013 was conducted from PubMed, Medline, Elsevier Science, Springer Link, Cochrane Library database, China biology medical literature database (CBM),China National Knowledge Infrastructure (CNKI),VIP,and Chinese literature database(Wang fang). A total of 1596 patients with cervical cancer and 2048 controls from the 12 studies on the relationship between gene polymorphism of HLA-DRB l and cervical cancer were performed and data were analyzed and processed using Review Manager 5.0 and Stata 11.0.<h4>Results</h4>Among the 13 family alleles, two (DRB103 and DRB108) were found to be negatively associated with cervical cancer in all studies or in Uighur subgroups, and two (DRB110 and DRB115) were positively associated with in all studies or in Uighur subgroups. Among the 25 specific alleles, six (DRB10301, 0403,0404, 0803, 1312 and 1502) were associated with an increased risk cervical cancer in all studies. No significant association was established for other HLA-DRB1 family alleles and specific alleles. Ethnicity partially explained the race influence of DRB112, DRB114, DRB10301, DRB10403, DRB10404, DRB10803, DRB11312 and DRB11502 phenotypes.<h4>Conclusion</h4>Our results support the hypothesis that the HLA-DRB1 family alleles and specific alleles might influence the susceptibility or resistance to cervical cancer, suggesting that immune regulation may play a key role in this disease, although further investigations are still needed.Lin-Zhen WeiHai-Lin WangXin LiuYa-Peng LuFei XuJin-Qiu YuanYa-Qin LingPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e88439 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lin-Zhen Wei Hai-Lin Wang Xin Liu Ya-Peng Lu Fei Xu Jin-Qiu Yuan Ya-Qin Ling Meta-analysis on the relationship between HLA-DRBl gene polymorphism and cervical cancer in Chinese population.
description	<h4>Aim</h4>To determine the association between HLA-DRB1 haplotypes and risk of cervical cancer in unselected and samples from Chinese ethnicities.<h4>Methods</h4>A comprehensive search for articles from their inception to April 1st, 2013 was conducted from PubMed, Medline, Elsevier Science, Springer Link, Cochrane Library database, China biology medical literature database (CBM),China National Knowledge Infrastructure (CNKI),VIP,and Chinese literature database(Wang fang). A total of 1596 patients with cervical cancer and 2048 controls from the 12 studies on the relationship between gene polymorphism of HLA-DRB l and cervical cancer were performed and data were analyzed and processed using Review Manager 5.0 and Stata 11.0.<h4>Results</h4>Among the 13 family alleles, two (DRB103 and DRB108) were found to be negatively associated with cervical cancer in all studies or in Uighur subgroups, and two (DRB110 and DRB115) were positively associated with in all studies or in Uighur subgroups. Among the 25 specific alleles, six (DRB10301, 0403,0404, 0803, 1312 and 1502) were associated with an increased risk cervical cancer in all studies. No significant association was established for other HLA-DRB1 family alleles and specific alleles. Ethnicity partially explained the race influence of DRB112, DRB114, DRB10301, DRB10403, DRB10404, DRB10803, DRB11312 and DRB11502 phenotypes.<h4>Conclusion</h4>Our results support the hypothesis that the HLA-DRB1 family alleles and specific alleles might influence the susceptibility or resistance to cervical cancer, suggesting that immune regulation may play a key role in this disease, although further investigations are still needed.
format	article
author	Lin-Zhen Wei Hai-Lin Wang Xin Liu Ya-Peng Lu Fei Xu Jin-Qiu Yuan Ya-Qin Ling
author_facet	Lin-Zhen Wei Hai-Lin Wang Xin Liu Ya-Peng Lu Fei Xu Jin-Qiu Yuan Ya-Qin Ling
author_sort	Lin-Zhen Wei
title	Meta-analysis on the relationship between HLA-DRBl gene polymorphism and cervical cancer in Chinese population.
title_short	Meta-analysis on the relationship between HLA-DRBl gene polymorphism and cervical cancer in Chinese population.
title_full	Meta-analysis on the relationship between HLA-DRBl gene polymorphism and cervical cancer in Chinese population.
title_fullStr	Meta-analysis on the relationship between HLA-DRBl gene polymorphism and cervical cancer in Chinese population.
title_full_unstemmed	Meta-analysis on the relationship between HLA-DRBl gene polymorphism and cervical cancer in Chinese population.
title_sort	meta-analysis on the relationship between hla-drbl gene polymorphism and cervical cancer in chinese population.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/b5d76bda33fb4c65b934203587e28c81
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Meta-analysis on the relationship between HLA-DRBl gene polymorphism and cervical cancer in Chinese population.

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