NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants

NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants

Longevity is often associated with stress resistance, but whether they are causally linked is incompletely understood. Here we investigate chemosensory-defective Caenorhabditis elegans mutants that are long-lived and stress resistant. We find that mutants in the intraflagellar transport protein gene...

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Bibliographic Details
Main Authors: Gabriel A Guerrero, Maxime J Derisbourg, Felix AMC Mayr, Laura E Wester, Marco Giorda, J Eike Dinort, Matías D Hartman, Klara Schilling, María José Alonso-De Gennaro, Ryan J Lu, Bérénice A Benayoun, Martin S Denzel
Format: article
Language:EN
Published: eLife Sciences Publications Ltd 2021
Subjects:
longevity
aging
chemosensory mutants
xenobiotic detoxification
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/b5da5aa2ccee4aeda56385feab2e8031
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https://doaj.org/article/b5da5aa2ccee4aeda56385feab2e8031

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