Breast cancer causes and treatment: where are we going wrong?

Colin B Seymour, Carmel MothersillMedical Physics and Applied Radiation Sciences Department, McMaster University, Hamilton, ON, CanadaAbstract: This discussion paper seeks to provoke thoughts about cancer research in general, and why breast cancer in particular is not yet “curable&rdqu...

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Autores principales:	Seymour CB, Mothersill C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b5dfdb27d3014bcf8a6ddd55131302c5
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spelling	oai:doaj.org-article:b5dfdb27d3014bcf8a6ddd55131302c52021-12-02T03:48:00ZBreast cancer causes and treatment: where are we going wrong?1179-1314https://doaj.org/article/b5dfdb27d3014bcf8a6ddd55131302c52013-12-01T00:00:00Zhttp://www.dovepress.com/breast-cancer-causes-and-treatment-where-are-we-going-wrong-a15151https://doaj.org/toc/1179-1314Colin B Seymour, Carmel MothersillMedical Physics and Applied Radiation Sciences Department, McMaster University, Hamilton, ON, CanadaAbstract: This discussion paper seeks to provoke thoughts about cancer research in general, and why breast cancer in particular is not yet “curable”. It asks the question – are we looking at the disease in the right way? Should we regard cancer as a progressive state, which is part of aging? Should we tailor treatment to “reset” the system or slow progression rather than try using toxic and aggressive therapy to kill every cancer cell (and sometimes also the patient)? The thesis is presented that we need to revisit our fundamental beliefs about the disease and then ask why we cling to beliefs that clearly are no longer valid. The paper also questions the role of ethics boards in hampering research and discusses the concept that breast cancer is an industry with vested interests involving profiteering by preventive, diagnostic, and therapeutic players. Finally, the paper suggests some ways forward based on emerging concepts in system biology and epigenetics.Keywords: breast cancer, causes, treatment, questioning paradigmsSeymour CBMothersill CDove Medical PressarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol 2013, Iss default, Pp 111-119 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Seymour CB Mothersill C Breast cancer causes and treatment: where are we going wrong?
description	Colin B Seymour, Carmel MothersillMedical Physics and Applied Radiation Sciences Department, McMaster University, Hamilton, ON, CanadaAbstract: This discussion paper seeks to provoke thoughts about cancer research in general, and why breast cancer in particular is not yet “curable”. It asks the question – are we looking at the disease in the right way? Should we regard cancer as a progressive state, which is part of aging? Should we tailor treatment to “reset” the system or slow progression rather than try using toxic and aggressive therapy to kill every cancer cell (and sometimes also the patient)? The thesis is presented that we need to revisit our fundamental beliefs about the disease and then ask why we cling to beliefs that clearly are no longer valid. The paper also questions the role of ethics boards in hampering research and discusses the concept that breast cancer is an industry with vested interests involving profiteering by preventive, diagnostic, and therapeutic players. Finally, the paper suggests some ways forward based on emerging concepts in system biology and epigenetics.Keywords: breast cancer, causes, treatment, questioning paradigms
format	article
author	Seymour CB Mothersill C
author_facet	Seymour CB Mothersill C
author_sort	Seymour CB
title	Breast cancer causes and treatment: where are we going wrong?
title_short	Breast cancer causes and treatment: where are we going wrong?
title_full	Breast cancer causes and treatment: where are we going wrong?
title_fullStr	Breast cancer causes and treatment: where are we going wrong?
title_full_unstemmed	Breast cancer causes and treatment: where are we going wrong?
title_sort	breast cancer causes and treatment: where are we going wrong?
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/b5dfdb27d3014bcf8a6ddd55131302c5
work_keys_str_mv	AT seymourcb breastcancercausesandtreatmentwherearewegoingwrong AT mothersillc breastcancercausesandtreatmentwherearewegoingwrong
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Breast cancer causes and treatment: where are we going wrong?

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