Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys.

Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys.

<h4>Background</h4>ST-246® is an antiviral, orally bioavailable small molecule in clinical development for treatment of orthopoxvirus infections. An intravenous (i.v.) formulation may be required for some hospitalized patients who are unable to take oral medication. An i.v. formulation h...

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Autores principales: Yali Chen, Adams Amantana, Shanthakumar R Tyavanagimatt, Daniela Zima, X Steven Yan, Gopi Kasi, Morgan Weeks, Melialani A Stone, William C Weimers, Peter Samuel, Ying Tan, Kevin F Jones, Daniel R Lee, Shirley S Kickner, Bradley M Saville, Martin Lauzon, Alan McIntyre, Kady M Honeychurch, Robert Jordan, Dennis E Hruby, Janet M Leeds
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/b5e19bc34bc24297a5169eda2e119b5a
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