Choosing what works for whom: towards a better use of mechanistic knowledge in clinical practice

Abstract Background Clinicians commonly try to use mechanism-based knowledge to make sense of the complexity and uncertainty of chronic pain treatments to create a rationale for their clinical decision-making. Although this seems intuitive, there are some problems with this approach. Discussion The...

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Autores principales:	Rafael K. Alaiti, Bruno T. Saragiotto, Leandro Fukusawa, Nayra D.A. Rabelo, Anamaria S. de Oliveira
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Chronic pain Musculoskeletal disorders Mediators Mechanisms of action Decision-making Miscellaneous systems and treatments RZ409.7-999
Acceso en línea:	https://doaj.org/article/b5e282f0ec49445a9a46bcbe618a903e
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spelling	oai:doaj.org-article:b5e282f0ec49445a9a46bcbe618a903e2021-12-05T12:26:30ZChoosing what works for whom: towards a better use of mechanistic knowledge in clinical practice10.1186/s40945-021-00122-12057-0082https://doaj.org/article/b5e282f0ec49445a9a46bcbe618a903e2021-12-01T00:00:00Zhttps://doi.org/10.1186/s40945-021-00122-1https://doaj.org/toc/2057-0082Abstract Background Clinicians commonly try to use mechanism-based knowledge to make sense of the complexity and uncertainty of chronic pain treatments to create a rationale for their clinical decision-making. Although this seems intuitive, there are some problems with this approach. Discussion The widespread use of mechanism-based knowledge in clinical practice can be a source of confusion for clinicians, especially when complex interventions with different proposed mechanisms of action are equally effective. Although the available mechanistic evidence is still of very poor quality, in choosing from various treatment options for people with chronic pain, an approach that correctly incorporates mechanistic reasoning might aid clinical thinking and practice. Conclusion By explaining that not all evidence of mechanism is the same and by making a proposal to start using mechanism-based knowledge in clinical practice properly, we hope to help clinicians to incorporate mechanistic reasoning to prioritize and start choosing what may best work for whom.Rafael K. AlaitiBruno T. SaragiottoLeandro FukusawaNayra D.A. RabeloAnamaria S. de OliveiraBMCarticleChronic painMusculoskeletal disordersMediatorsMechanisms of actionDecision-makingMiscellaneous systems and treatmentsRZ409.7-999ENArchives of Physiotherapy, Vol 11, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chronic pain Musculoskeletal disorders Mediators Mechanisms of action Decision-making Miscellaneous systems and treatments RZ409.7-999
spellingShingle	Chronic pain Musculoskeletal disorders Mediators Mechanisms of action Decision-making Miscellaneous systems and treatments RZ409.7-999 Rafael K. Alaiti Bruno T. Saragiotto Leandro Fukusawa Nayra D.A. Rabelo Anamaria S. de Oliveira Choosing what works for whom: towards a better use of mechanistic knowledge in clinical practice
description	Abstract Background Clinicians commonly try to use mechanism-based knowledge to make sense of the complexity and uncertainty of chronic pain treatments to create a rationale for their clinical decision-making. Although this seems intuitive, there are some problems with this approach. Discussion The widespread use of mechanism-based knowledge in clinical practice can be a source of confusion for clinicians, especially when complex interventions with different proposed mechanisms of action are equally effective. Although the available mechanistic evidence is still of very poor quality, in choosing from various treatment options for people with chronic pain, an approach that correctly incorporates mechanistic reasoning might aid clinical thinking and practice. Conclusion By explaining that not all evidence of mechanism is the same and by making a proposal to start using mechanism-based knowledge in clinical practice properly, we hope to help clinicians to incorporate mechanistic reasoning to prioritize and start choosing what may best work for whom.
format	article
author	Rafael K. Alaiti Bruno T. Saragiotto Leandro Fukusawa Nayra D.A. Rabelo Anamaria S. de Oliveira
author_facet	Rafael K. Alaiti Bruno T. Saragiotto Leandro Fukusawa Nayra D.A. Rabelo Anamaria S. de Oliveira
author_sort	Rafael K. Alaiti
title	Choosing what works for whom: towards a better use of mechanistic knowledge in clinical practice
title_short	Choosing what works for whom: towards a better use of mechanistic knowledge in clinical practice
title_full	Choosing what works for whom: towards a better use of mechanistic knowledge in clinical practice
title_fullStr	Choosing what works for whom: towards a better use of mechanistic knowledge in clinical practice
title_full_unstemmed	Choosing what works for whom: towards a better use of mechanistic knowledge in clinical practice
title_sort	choosing what works for whom: towards a better use of mechanistic knowledge in clinical practice
publisher	BMC
publishDate	2021
url	https://doaj.org/article/b5e282f0ec49445a9a46bcbe618a903e
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Choosing what works for whom: towards a better use of mechanistic knowledge in clinical practice

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