MRI-detectable polymeric micelles incorporating platinum anticancer drugs enhance survival in an advanced hepatocellular carcinoma model

Nguyen Quoc Vinh,1 Shigeyuki Naka,1 Horacio Cabral,2 Hiroyuki Murayama,1 Sachiko Kaida,1 Kazunori Kataoka,2 Shigehiro Morikawa,3 Tohru Tani4 1Department of Surgery, Shiga University of Medical Science, Shiga, Japan; 2Department of Bioengineering, Graduate School of Engineering, The University of To...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Vinh NQ, Naka S, Cabral H, Murayama H, Kaida S, Kataoka K, Morikawa S, Tani T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b5e2f7c550414a16b0f9450e3aaef9a8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b5e2f7c550414a16b0f9450e3aaef9a8
record_format	dspace
spelling	oai:doaj.org-article:b5e2f7c550414a16b0f9450e3aaef9a82021-12-02T01:46:44ZMRI-detectable polymeric micelles incorporating platinum anticancer drugs enhance survival in an advanced hepatocellular carcinoma model1178-2013https://doaj.org/article/b5e2f7c550414a16b0f9450e3aaef9a82015-06-01T00:00:00Zhttp://www.dovepress.com/mri-detectable-polymeric-micelles-incorporating-platinum-anticancer-dr-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Nguyen Quoc Vinh,1 Shigeyuki Naka,1 Horacio Cabral,2 Hiroyuki Murayama,1 Sachiko Kaida,1 Kazunori Kataoka,2 Shigehiro Morikawa,3 Tohru Tani4 1Department of Surgery, Shiga University of Medical Science, Shiga, Japan; 2Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan; 3Department of Nursing, Shiga University of Medical Science, Shiga, Japan; 4Biomedical Innovation Center, Shiga University of Medical Science, Shiga, Japan Abstract: Hepatocellular carcinoma (HCC) is one of the most intractable and lethal cancers; most cases are diagnosed at advanced stages with underlying liver dysfunction and are frequently resistant to conventional chemotherapy and radiotherapy. The development of tumor-targeting systems may improve treatment outcomes. Nanomedicine platforms are of particular interest for enhancing chemotherapeutic efficiency, and they include polymeric micelles, which enable targeting of multiple drugs to solid tumors, including imaging and therapeutic agents. This allows concurrent diagnosis, targeting strategy validation, and efficacy assessment. We used polymeric micelles containing the T1-weighted magnetic resonance imaging contrast agent gadolinium-diethylenetriaminpentaacetic acid (Gd-DTPA) and the parent complex of the anticancer drug oxaliplatin [(1,2-diaminocyclohexane)platinum(II) (DACHPt)] for simultaneous imaging and therapy in an orthotopic rat model of HCC. The Gd-DTPA/DACHPt-loaded micelles were injected into the hepatic artery, and magnetic resonance imaging performance and antitumor activity against HCC, as well as adverse drug reactions were assessed. After a single administration, the micelles achieved strong and specific tumor contrast enhancement, induced high levels of tumor apoptosis, and significantly suppressed tumor size and growth. Moreover, the micelles did not induce severe adverse reactions and significantly improved survival outcomes in comparison to oxaliplatin or saline controls. Our results suggest that Gd-DTPA/DACHPt-loaded micelles are a promising approach for effective diagnosis and treatment of advanced HCC. Keywords: Gd-DTPA/DACHPt-loaded micelles, polymeric micelles, drug delivery, hepatocellular carcinomaVinh NQNaka SCabral HMurayama HKaida SKataoka KMorikawa STani TDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 4137-4147 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Vinh NQ Naka S Cabral H Murayama H Kaida S Kataoka K Morikawa S Tani T MRI-detectable polymeric micelles incorporating platinum anticancer drugs enhance survival in an advanced hepatocellular carcinoma model
description	Nguyen Quoc Vinh,1 Shigeyuki Naka,1 Horacio Cabral,2 Hiroyuki Murayama,1 Sachiko Kaida,1 Kazunori Kataoka,2 Shigehiro Morikawa,3 Tohru Tani4 1Department of Surgery, Shiga University of Medical Science, Shiga, Japan; 2Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan; 3Department of Nursing, Shiga University of Medical Science, Shiga, Japan; 4Biomedical Innovation Center, Shiga University of Medical Science, Shiga, Japan Abstract: Hepatocellular carcinoma (HCC) is one of the most intractable and lethal cancers; most cases are diagnosed at advanced stages with underlying liver dysfunction and are frequently resistant to conventional chemotherapy and radiotherapy. The development of tumor-targeting systems may improve treatment outcomes. Nanomedicine platforms are of particular interest for enhancing chemotherapeutic efficiency, and they include polymeric micelles, which enable targeting of multiple drugs to solid tumors, including imaging and therapeutic agents. This allows concurrent diagnosis, targeting strategy validation, and efficacy assessment. We used polymeric micelles containing the T1-weighted magnetic resonance imaging contrast agent gadolinium-diethylenetriaminpentaacetic acid (Gd-DTPA) and the parent complex of the anticancer drug oxaliplatin [(1,2-diaminocyclohexane)platinum(II) (DACHPt)] for simultaneous imaging and therapy in an orthotopic rat model of HCC. The Gd-DTPA/DACHPt-loaded micelles were injected into the hepatic artery, and magnetic resonance imaging performance and antitumor activity against HCC, as well as adverse drug reactions were assessed. After a single administration, the micelles achieved strong and specific tumor contrast enhancement, induced high levels of tumor apoptosis, and significantly suppressed tumor size and growth. Moreover, the micelles did not induce severe adverse reactions and significantly improved survival outcomes in comparison to oxaliplatin or saline controls. Our results suggest that Gd-DTPA/DACHPt-loaded micelles are a promising approach for effective diagnosis and treatment of advanced HCC. Keywords: Gd-DTPA/DACHPt-loaded micelles, polymeric micelles, drug delivery, hepatocellular carcinoma
format	article
author	Vinh NQ Naka S Cabral H Murayama H Kaida S Kataoka K Morikawa S Tani T
author_facet	Vinh NQ Naka S Cabral H Murayama H Kaida S Kataoka K Morikawa S Tani T
author_sort	Vinh NQ
title	MRI-detectable polymeric micelles incorporating platinum anticancer drugs enhance survival in an advanced hepatocellular carcinoma model
title_short	MRI-detectable polymeric micelles incorporating platinum anticancer drugs enhance survival in an advanced hepatocellular carcinoma model
title_full	MRI-detectable polymeric micelles incorporating platinum anticancer drugs enhance survival in an advanced hepatocellular carcinoma model
title_fullStr	MRI-detectable polymeric micelles incorporating platinum anticancer drugs enhance survival in an advanced hepatocellular carcinoma model
title_full_unstemmed	MRI-detectable polymeric micelles incorporating platinum anticancer drugs enhance survival in an advanced hepatocellular carcinoma model
title_sort	mri-detectable polymeric micelles incorporating platinum anticancer drugs enhance survival in an advanced hepatocellular carcinoma model
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/b5e2f7c550414a16b0f9450e3aaef9a8
work_keys_str_mv	AT vinhnq mridetectablepolymericmicellesincorporatingplatinumanticancerdrugsenhancesurvivalinanadvancedhepatocellularcarcinomamodel AT nakas mridetectablepolymericmicellesincorporatingplatinumanticancerdrugsenhancesurvivalinanadvancedhepatocellularcarcinomamodel AT cabralh mridetectablepolymericmicellesincorporatingplatinumanticancerdrugsenhancesurvivalinanadvancedhepatocellularcarcinomamodel AT murayamah mridetectablepolymericmicellesincorporatingplatinumanticancerdrugsenhancesurvivalinanadvancedhepatocellularcarcinomamodel AT kaidas mridetectablepolymericmicellesincorporatingplatinumanticancerdrugsenhancesurvivalinanadvancedhepatocellularcarcinomamodel AT kataokak mridetectablepolymericmicellesincorporatingplatinumanticancerdrugsenhancesurvivalinanadvancedhepatocellularcarcinomamodel AT morikawas mridetectablepolymericmicellesincorporatingplatinumanticancerdrugsenhancesurvivalinanadvancedhepatocellularcarcinomamodel AT tanit mridetectablepolymericmicellesincorporatingplatinumanticancerdrugsenhancesurvivalinanadvancedhepatocellularcarcinomamodel
_version_	1718402919377666048

MRI-detectable polymeric micelles incorporating platinum anticancer drugs enhance survival in an advanced hepatocellular carcinoma model

Ejemplares similares