Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma
Chromothripsis is associated with unfavourable outcomes in multiple myeloma (MM), but its detection usually requires whole genome sequencing. Here the authors develop an approach to detect chromothripsis in MM based on copy-number signatures that also works with whole exome sequencing data.
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Nature Portfolio
2021
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oai:doaj.org-article:b5e6a8716f6d4f72afb2988be34823622021-12-02T19:02:36ZCopy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma10.1038/s41467-021-25469-82041-1723https://doaj.org/article/b5e6a8716f6d4f72afb2988be34823622021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25469-8https://doaj.org/toc/2041-1723Chromothripsis is associated with unfavourable outcomes in multiple myeloma (MM), but its detection usually requires whole genome sequencing. Here the authors develop an approach to detect chromothripsis in MM based on copy-number signatures that also works with whole exome sequencing data.Kylee H. MaclachlanEven H. RustadAndriy DerkachBinbin Zheng-LinVenkata YellapantulaBenjamin DiamondMalin HultcrantzBachisio ZicchedduEileen M. BoylePatrick BlaneyNiccolò BolliYanming ZhangAhmet DoganAlexander M. LesokhinGareth J. MorganOla LandgrenFrancesco MauraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Kylee H. Maclachlan Even H. Rustad Andriy Derkach Binbin Zheng-Lin Venkata Yellapantula Benjamin Diamond Malin Hultcrantz Bachisio Ziccheddu Eileen M. Boyle Patrick Blaney Niccolò Bolli Yanming Zhang Ahmet Dogan Alexander M. Lesokhin Gareth J. Morgan Ola Landgren Francesco Maura Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma |
| description |
Chromothripsis is associated with unfavourable outcomes in multiple myeloma (MM), but its detection usually requires whole genome sequencing. Here the authors develop an approach to detect chromothripsis in MM based on copy-number signatures that also works with whole exome sequencing data. |
| format |
article |
| author |
Kylee H. Maclachlan Even H. Rustad Andriy Derkach Binbin Zheng-Lin Venkata Yellapantula Benjamin Diamond Malin Hultcrantz Bachisio Ziccheddu Eileen M. Boyle Patrick Blaney Niccolò Bolli Yanming Zhang Ahmet Dogan Alexander M. Lesokhin Gareth J. Morgan Ola Landgren Francesco Maura |
| author_facet |
Kylee H. Maclachlan Even H. Rustad Andriy Derkach Binbin Zheng-Lin Venkata Yellapantula Benjamin Diamond Malin Hultcrantz Bachisio Ziccheddu Eileen M. Boyle Patrick Blaney Niccolò Bolli Yanming Zhang Ahmet Dogan Alexander M. Lesokhin Gareth J. Morgan Ola Landgren Francesco Maura |
| author_sort |
Kylee H. Maclachlan |
| title |
Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma |
| title_short |
Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma |
| title_full |
Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma |
| title_fullStr |
Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma |
| title_full_unstemmed |
Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma |
| title_sort |
copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/b5e6a8716f6d4f72afb2988be3482362 |
| work_keys_str_mv |
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1718377232874864640 |