Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma

Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma

Chromothripsis is associated with unfavourable outcomes in multiple myeloma (MM), but its detection usually requires whole genome sequencing. Here the authors develop an approach to detect chromothripsis in MM based on copy-number signatures that also works with whole exome sequencing data.

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Autores principales: Kylee H. Maclachlan, Even H. Rustad, Andriy Derkach, Binbin Zheng-Lin, Venkata Yellapantula, Benjamin Diamond, Malin Hultcrantz, Bachisio Ziccheddu, Eileen M. Boyle, Patrick Blaney, Niccolò Bolli, Yanming Zhang, Ahmet Dogan, Alexander M. Lesokhin, Gareth J. Morgan, Ola Landgren, Francesco Maura
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/b5e6a8716f6d4f72afb2988be3482362
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https://doaj.org/article/b5e6a8716f6d4f72afb2988be3482362

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