The way of SARS-CoV-2 vaccine development: success and challenges

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). To halt the pandemic, multiple SARS-CoV-2 vaccines have been developed and several have been allowed for emergency use and rollout worldwide. With novel SARS-CoV-2 var...

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Autores principales:	Yetian Dong, Tong Dai, Bin Wang, Lei Zhang, Ling-hui Zeng, Jun Huang, Haiyan Yan, Long Zhang, Fangfang Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Medicine R Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b5e9d063126f4948b1f5c2cde8276777
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spelling	oai:doaj.org-article:b5e9d063126f4948b1f5c2cde82767772021-11-14T12:10:49ZThe way of SARS-CoV-2 vaccine development: success and challenges10.1038/s41392-021-00796-w2059-3635https://doaj.org/article/b5e9d063126f4948b1f5c2cde82767772021-11-01T00:00:00Zhttps://doi.org/10.1038/s41392-021-00796-whttps://doaj.org/toc/2059-3635Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). To halt the pandemic, multiple SARS-CoV-2 vaccines have been developed and several have been allowed for emergency use and rollout worldwide. With novel SARS-CoV-2 variants emerging and circulating widely, whether the original vaccines that were designed based on the wild-type SARS-CoV-2 were effective against these variants has been a contentious discussion. Moreover, some studies revealed the long-term changes of immune responses post SARS-CoV-2 infection or vaccination and the factors that might impact the vaccine-induced immunity. Thus, in this review, we have summarized the influence of mutational hotspots on the vaccine efficacy and characteristics of variants of interest and concern. We have also discussed the reasons that might result in discrepancies in the efficacy of different vaccines estimated in different trials. Furthermore, we provided an overview of the duration of immune responses after natural infection or vaccination and shed light on the factors that may affect the immunity induced by the vaccines, such as special disease conditions, sex, and pre-existing immunity, with the aim of aiding in combating COVID-19 and distributing SARS-CoV-2 vaccines under the prevalence of diverse SARS-CoV-2 variants.Yetian DongTong DaiBin WangLei ZhangLing-hui ZengJun HuangHaiyan YanLong ZhangFangfang ZhouNature Publishing GrouparticleMedicineRBiology (General)QH301-705.5ENSignal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Biology (General) QH301-705.5
spellingShingle	Medicine R Biology (General) QH301-705.5 Yetian Dong Tong Dai Bin Wang Lei Zhang Ling-hui Zeng Jun Huang Haiyan Yan Long Zhang Fangfang Zhou The way of SARS-CoV-2 vaccine development: success and challenges
description	Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). To halt the pandemic, multiple SARS-CoV-2 vaccines have been developed and several have been allowed for emergency use and rollout worldwide. With novel SARS-CoV-2 variants emerging and circulating widely, whether the original vaccines that were designed based on the wild-type SARS-CoV-2 were effective against these variants has been a contentious discussion. Moreover, some studies revealed the long-term changes of immune responses post SARS-CoV-2 infection or vaccination and the factors that might impact the vaccine-induced immunity. Thus, in this review, we have summarized the influence of mutational hotspots on the vaccine efficacy and characteristics of variants of interest and concern. We have also discussed the reasons that might result in discrepancies in the efficacy of different vaccines estimated in different trials. Furthermore, we provided an overview of the duration of immune responses after natural infection or vaccination and shed light on the factors that may affect the immunity induced by the vaccines, such as special disease conditions, sex, and pre-existing immunity, with the aim of aiding in combating COVID-19 and distributing SARS-CoV-2 vaccines under the prevalence of diverse SARS-CoV-2 variants.
format	article
author	Yetian Dong Tong Dai Bin Wang Lei Zhang Ling-hui Zeng Jun Huang Haiyan Yan Long Zhang Fangfang Zhou
author_facet	Yetian Dong Tong Dai Bin Wang Lei Zhang Ling-hui Zeng Jun Huang Haiyan Yan Long Zhang Fangfang Zhou
author_sort	Yetian Dong
title	The way of SARS-CoV-2 vaccine development: success and challenges
title_short	The way of SARS-CoV-2 vaccine development: success and challenges
title_full	The way of SARS-CoV-2 vaccine development: success and challenges
title_fullStr	The way of SARS-CoV-2 vaccine development: success and challenges
title_full_unstemmed	The way of SARS-CoV-2 vaccine development: success and challenges
title_sort	way of sars-cov-2 vaccine development: success and challenges
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/b5e9d063126f4948b1f5c2cde8276777
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The way of SARS-CoV-2 vaccine development: success and challenges

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