Long lasting modulation of cortical oscillations after continuous theta burst transcranial magnetic stimulation.

Transcranial magnetic theta burst stimulation (TBS) differs from other high-frequency rTMS protocols because it induces plastic changes up to an hour despite lower stimulus intensity and shorter duration of stimulation. However, the effects of TBS on neuronal oscillations remain unclear. In this stu...

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Autores principales:	Nor Azila Noh, Giorgio Fuggetta, Paolo Manganotti, Antonio Fiaschi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b5edb1a226de4af4a15fb434d65331e1
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spelling	oai:doaj.org-article:b5edb1a226de4af4a15fb434d65331e12021-11-18T07:23:09ZLong lasting modulation of cortical oscillations after continuous theta burst transcranial magnetic stimulation.1932-620310.1371/journal.pone.0035080https://doaj.org/article/b5edb1a226de4af4a15fb434d65331e12012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22496893/?tool=EBIhttps://doaj.org/toc/1932-6203Transcranial magnetic theta burst stimulation (TBS) differs from other high-frequency rTMS protocols because it induces plastic changes up to an hour despite lower stimulus intensity and shorter duration of stimulation. However, the effects of TBS on neuronal oscillations remain unclear. In this study, we used electroencephalography (EEG) to investigate changes of neuronal oscillations after continuous TBS (cTBS), the protocol that emulates long-term depression (LTD) form of synaptic plasticity. We randomly divided 26 healthy humans into two groups receiving either Active or Sham cTBS as control over the left primary motor cortex (M1). Post-cTBS aftereffects were assessed with behavioural measurements at rest using motor evoked potentials (MEPs) and at active state during the execution of a choice reaction time (RT) task in combination with continuous electrophysiological recordings. The cTBS-induced EEG oscillations were assessed using event-related power (ERPow), which reflected regional oscillatory activity of neural assemblies of θ (4-7.5 Hz), low α (8-9.5 Hz), µ (10-12.5 Hz), low β (13-19.5 Hz), and high β (20-30 Hz) brain rhythms. Results revealed 20-min suppression of MEPs and at least 30-min increase of ERPow modulation, suggesting that besides MEPs, EEG has the potential to provide an accurate cortical readout to assess cortical excitability and to investigate the interference of cortical oscillations in the human brain post-cTBS. We also observed a predominant modulation of β frequency band, supporting the hypothesis that cTBS acts more on cortical level. Theta oscillations were also modulated during rest implying the involvement of independent cortical theta generators over the motor network post cTBS. This work provided more insights into the underlying mechanisms of cTBS, providing a possible link between synchronised neural oscillations and LTD in humans.Nor Azila NohGiorgio FuggettaPaolo ManganottiAntonio FiaschiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e35080 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nor Azila Noh Giorgio Fuggetta Paolo Manganotti Antonio Fiaschi Long lasting modulation of cortical oscillations after continuous theta burst transcranial magnetic stimulation.
description	Transcranial magnetic theta burst stimulation (TBS) differs from other high-frequency rTMS protocols because it induces plastic changes up to an hour despite lower stimulus intensity and shorter duration of stimulation. However, the effects of TBS on neuronal oscillations remain unclear. In this study, we used electroencephalography (EEG) to investigate changes of neuronal oscillations after continuous TBS (cTBS), the protocol that emulates long-term depression (LTD) form of synaptic plasticity. We randomly divided 26 healthy humans into two groups receiving either Active or Sham cTBS as control over the left primary motor cortex (M1). Post-cTBS aftereffects were assessed with behavioural measurements at rest using motor evoked potentials (MEPs) and at active state during the execution of a choice reaction time (RT) task in combination with continuous electrophysiological recordings. The cTBS-induced EEG oscillations were assessed using event-related power (ERPow), which reflected regional oscillatory activity of neural assemblies of θ (4-7.5 Hz), low α (8-9.5 Hz), µ (10-12.5 Hz), low β (13-19.5 Hz), and high β (20-30 Hz) brain rhythms. Results revealed 20-min suppression of MEPs and at least 30-min increase of ERPow modulation, suggesting that besides MEPs, EEG has the potential to provide an accurate cortical readout to assess cortical excitability and to investigate the interference of cortical oscillations in the human brain post-cTBS. We also observed a predominant modulation of β frequency band, supporting the hypothesis that cTBS acts more on cortical level. Theta oscillations were also modulated during rest implying the involvement of independent cortical theta generators over the motor network post cTBS. This work provided more insights into the underlying mechanisms of cTBS, providing a possible link between synchronised neural oscillations and LTD in humans.
format	article
author	Nor Azila Noh Giorgio Fuggetta Paolo Manganotti Antonio Fiaschi
author_facet	Nor Azila Noh Giorgio Fuggetta Paolo Manganotti Antonio Fiaschi
author_sort	Nor Azila Noh
title	Long lasting modulation of cortical oscillations after continuous theta burst transcranial magnetic stimulation.
title_short	Long lasting modulation of cortical oscillations after continuous theta burst transcranial magnetic stimulation.
title_full	Long lasting modulation of cortical oscillations after continuous theta burst transcranial magnetic stimulation.
title_fullStr	Long lasting modulation of cortical oscillations after continuous theta burst transcranial magnetic stimulation.
title_full_unstemmed	Long lasting modulation of cortical oscillations after continuous theta burst transcranial magnetic stimulation.
title_sort	long lasting modulation of cortical oscillations after continuous theta burst transcranial magnetic stimulation.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/b5edb1a226de4af4a15fb434d65331e1
work_keys_str_mv	AT norazilanoh longlastingmodulationofcorticaloscillationsaftercontinuousthetabursttranscranialmagneticstimulation AT giorgiofuggetta longlastingmodulationofcorticaloscillationsaftercontinuousthetabursttranscranialmagneticstimulation AT paolomanganotti longlastingmodulationofcorticaloscillationsaftercontinuousthetabursttranscranialmagneticstimulation AT antoniofiaschi longlastingmodulationofcorticaloscillationsaftercontinuousthetabursttranscranialmagneticstimulation
_version_	1718423558204424192

Long lasting modulation of cortical oscillations after continuous theta burst transcranial magnetic stimulation.

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