Self-organizing mechanism for development of space-filling neuronal dendrites.

Neurons develop distinctive dendritic morphologies to receive and process information. Previous experiments showed that competitive dendro-dendritic interactions play critical roles in shaping dendrites of the space-filling type, which uniformly cover their receptive field. We incorporated this find...

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Autores principales:	Kaoru Sugimura, Kohei Shimono, Tadashi Uemura, Atsushi Mochizuki
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2007
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b5eee473c46c41c28df88642c4af587a
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spelling	oai:doaj.org-article:b5eee473c46c41c28df88642c4af587a2021-11-25T05:41:30ZSelf-organizing mechanism for development of space-filling neuronal dendrites.1553-734X1553-735810.1371/journal.pcbi.0030212https://doaj.org/article/b5eee473c46c41c28df88642c4af587a2007-11-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.0030212https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Neurons develop distinctive dendritic morphologies to receive and process information. Previous experiments showed that competitive dendro-dendritic interactions play critical roles in shaping dendrites of the space-filling type, which uniformly cover their receptive field. We incorporated this finding in constructing a new mathematical model, in which reaction dynamics of two chemicals (activator and suppressor) are coupled to neuronal dendrite growth. Our numerical analysis determined the conditions for dendritic branching and suggested that the self-organizing property of the proposed system can underlie dendritogenesis. Furthermore, we found a clear correlation between dendrite shape and the distribution of the activator, thus providing a morphological criterion to predict the in vivo distribution of the hypothetical molecular complexes responsible for dendrite elongation and branching.Kaoru SugimuraKohei ShimonoTadashi UemuraAtsushi MochizukiPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 3, Iss 11, p e212 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Kaoru Sugimura Kohei Shimono Tadashi Uemura Atsushi Mochizuki Self-organizing mechanism for development of space-filling neuronal dendrites.
description	Neurons develop distinctive dendritic morphologies to receive and process information. Previous experiments showed that competitive dendro-dendritic interactions play critical roles in shaping dendrites of the space-filling type, which uniformly cover their receptive field. We incorporated this finding in constructing a new mathematical model, in which reaction dynamics of two chemicals (activator and suppressor) are coupled to neuronal dendrite growth. Our numerical analysis determined the conditions for dendritic branching and suggested that the self-organizing property of the proposed system can underlie dendritogenesis. Furthermore, we found a clear correlation between dendrite shape and the distribution of the activator, thus providing a morphological criterion to predict the in vivo distribution of the hypothetical molecular complexes responsible for dendrite elongation and branching.
format	article
author	Kaoru Sugimura Kohei Shimono Tadashi Uemura Atsushi Mochizuki
author_facet	Kaoru Sugimura Kohei Shimono Tadashi Uemura Atsushi Mochizuki
author_sort	Kaoru Sugimura
title	Self-organizing mechanism for development of space-filling neuronal dendrites.
title_short	Self-organizing mechanism for development of space-filling neuronal dendrites.
title_full	Self-organizing mechanism for development of space-filling neuronal dendrites.
title_fullStr	Self-organizing mechanism for development of space-filling neuronal dendrites.
title_full_unstemmed	Self-organizing mechanism for development of space-filling neuronal dendrites.
title_sort	self-organizing mechanism for development of space-filling neuronal dendrites.
publisher	Public Library of Science (PLoS)
publishDate	2007
url	https://doaj.org/article/b5eee473c46c41c28df88642c4af587a
work_keys_str_mv	AT kaorusugimura selforganizingmechanismfordevelopmentofspacefillingneuronaldendrites AT koheishimono selforganizingmechanismfordevelopmentofspacefillingneuronaldendrites AT tadashiuemura selforganizingmechanismfordevelopmentofspacefillingneuronaldendrites AT atsushimochizuki selforganizingmechanismfordevelopmentofspacefillingneuronaldendrites
_version_	1718414539304730624

Self-organizing mechanism for development of space-filling neuronal dendrites.

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