IMMUNOREGULATORY PROPERTIES OF THROMBOSPONDIN-1, A EXTRACELLULAR MATRIX COMPONENT AND ANGIOGENESIS INHIBITOR

Abstract. Thrombospondin-1 (TSP-1) is an extracellular matrix glycoprotein that can positively or negatively regulate adhesion, motility, proliferation, and survival of various cell types, including cells of the immune system. It is secreted by numerous cell types, and its expression is predominant...

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Autores principales:	S. A. Kuznetsova, A. V. Krylov, E. P. Kiseleva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	thrombospondin extracellular matrix angiogenesis inflammation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b5f0605254004b2e89233c83845ed70b
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spelling	oai:doaj.org-article:b5f0605254004b2e89233c83845ed70b2021-11-18T08:03:39ZIMMUNOREGULATORY PROPERTIES OF THROMBOSPONDIN-1, A EXTRACELLULAR MATRIX COMPONENT AND ANGIOGENESIS INHIBITOR1563-06252313-741X10.15789/1563-0625-2008-6-499-506https://doaj.org/article/b5f0605254004b2e89233c83845ed70b2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/251https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Thrombospondin-1 (TSP-1) is an extracellular matrix glycoprotein that can positively or negatively regulate adhesion, motility, proliferation, and survival of various cell types, including cells of the immune system. It is secreted by numerous cell types, and its expression is predominant in areas of tissue injury or remodeling. Initially, TSP-1 was identified as one of the first endogenous inhibitors of angiogenesis. This factor is known to be a potent inhibitor of angiogenesis, as demonstrated by in vitro inhibition of endothelial cell proliferation and in vivo vascular growth. Since then, much has been learned about its ability to modulate cell behavior during embryonic development, to maintain normal homeostasis of adult organism, wound healing, immune response, tumor growth. TSP-1 is a large, trimeric, matricellular protein, composed of multiple structural domains that interact with a diverse array of receptors and molecules. Many hematopoietic and immune cells are able of both producing TSP-1 and responding to it. This review presents a current understanding on participation of TSP-1 in differentiation, maturation and functioning of immune cells. (Med. Immunol., vol. 10, N 6, pp 499-506).S. A. KuznetsovaA. V. KrylovE. P. KiselevaSPb RAACIarticlethrombospondinextracellular matrixangiogenesisinflammationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 6, Pp 499-506 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	thrombospondin extracellular matrix angiogenesis inflammation Immunologic diseases. Allergy RC581-607
spellingShingle	thrombospondin extracellular matrix angiogenesis inflammation Immunologic diseases. Allergy RC581-607 S. A. Kuznetsova A. V. Krylov E. P. Kiseleva IMMUNOREGULATORY PROPERTIES OF THROMBOSPONDIN-1, A EXTRACELLULAR MATRIX COMPONENT AND ANGIOGENESIS INHIBITOR
description	Abstract. Thrombospondin-1 (TSP-1) is an extracellular matrix glycoprotein that can positively or negatively regulate adhesion, motility, proliferation, and survival of various cell types, including cells of the immune system. It is secreted by numerous cell types, and its expression is predominant in areas of tissue injury or remodeling. Initially, TSP-1 was identified as one of the first endogenous inhibitors of angiogenesis. This factor is known to be a potent inhibitor of angiogenesis, as demonstrated by in vitro inhibition of endothelial cell proliferation and in vivo vascular growth. Since then, much has been learned about its ability to modulate cell behavior during embryonic development, to maintain normal homeostasis of adult organism, wound healing, immune response, tumor growth. TSP-1 is a large, trimeric, matricellular protein, composed of multiple structural domains that interact with a diverse array of receptors and molecules. Many hematopoietic and immune cells are able of both producing TSP-1 and responding to it. This review presents a current understanding on participation of TSP-1 in differentiation, maturation and functioning of immune cells. (Med. Immunol., vol. 10, N 6, pp 499-506).
format	article
author	S. A. Kuznetsova A. V. Krylov E. P. Kiseleva
author_facet	S. A. Kuznetsova A. V. Krylov E. P. Kiseleva
author_sort	S. A. Kuznetsova
title	IMMUNOREGULATORY PROPERTIES OF THROMBOSPONDIN-1, A EXTRACELLULAR MATRIX COMPONENT AND ANGIOGENESIS INHIBITOR
title_short	IMMUNOREGULATORY PROPERTIES OF THROMBOSPONDIN-1, A EXTRACELLULAR MATRIX COMPONENT AND ANGIOGENESIS INHIBITOR
title_full	IMMUNOREGULATORY PROPERTIES OF THROMBOSPONDIN-1, A EXTRACELLULAR MATRIX COMPONENT AND ANGIOGENESIS INHIBITOR
title_fullStr	IMMUNOREGULATORY PROPERTIES OF THROMBOSPONDIN-1, A EXTRACELLULAR MATRIX COMPONENT AND ANGIOGENESIS INHIBITOR
title_full_unstemmed	IMMUNOREGULATORY PROPERTIES OF THROMBOSPONDIN-1, A EXTRACELLULAR MATRIX COMPONENT AND ANGIOGENESIS INHIBITOR
title_sort	immunoregulatory properties of thrombospondin-1, a extracellular matrix component and angiogenesis inhibitor
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/b5f0605254004b2e89233c83845ed70b
work_keys_str_mv	AT sakuznetsova immunoregulatorypropertiesofthrombospondin1aextracellularmatrixcomponentandangiogenesisinhibitor AT avkrylov immunoregulatorypropertiesofthrombospondin1aextracellularmatrixcomponentandangiogenesisinhibitor AT epkiseleva immunoregulatorypropertiesofthrombospondin1aextracellularmatrixcomponentandangiogenesisinhibitor
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IMMUNOREGULATORY PROPERTIES OF THROMBOSPONDIN-1, A EXTRACELLULAR MATRIX COMPONENT AND ANGIOGENESIS INHIBITOR

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